Engineering aromatic L-amino acid transaminase for the asymmetric synthesis of constrained analogs of L-phenylalanine

Biotechnology and Bioengineering

Volumn 94, Issue 5, 2006, Pages 842-850

  Cho, Byung Kwan ^a,c   Seo, Joo Hyun ^a   Kang, Taek Jin ^a,d   Kim, Juhan ^a   Park, Hyung Yeon ^b   Lee, Bon Su ^b   Kim, Byung Gee ^a,e  

^a Seoul National University   (South Korea)

^b Inha University   (South Korea)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY AT BUFFALO   (United States)

^e UNIVERSITY OF COLORADO   (United States)

Author keywords

Homology modeling; L diphenylalanine; Site directed mutagenesis; Transaminase; Unnatural amino acid

Indexed keywords

AMINO ACIDS; AROMATIC COMPOUNDS; MUTAGENESIS; SYNTHESIS (CHEMICAL);

HOMOLOGY MODELING; L-DIPHENYLALANINE; SITE-DIRECTED MUTAGENESIS; TRANSAMINASE; UNNATURAL AMINO ACID;

ENZYMES;

AMINO ACID; AMINOTRANSFERASE; AROMATIC LEVO AMINO ACID TRANSAMINASE; CARBOXYL GROUP; CARBOXYLIC ACID; PHENYLALANINE; PHOSPHATE; PYRIDOXAL 5 PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; ENTEROBACTER; HYDROGEN BOND; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; SITE DIRECTED MUTAGENESIS; TRANSAMINATION;

AMINO ACIDS, AROMATIC; ENTEROBACTER; ENZYME ACTIVATION; ESCHERICHIA COLI; GENETIC ENHANCEMENT; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROTEIN ENGINEERING; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSAMINASES;

ENTEROBACTER SP.;

EID: 33746894637     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.20902     Document Type: Article

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