CYP2A6 polymorphisms in Malays, Chinese and Indians

Xenobiotica

Volumn 36, Issue 8, 2006, Pages 684-692

  Nurfadhlina, M ^a   Foong, K ^b   Teh, L K ^c   Tan, S C ^b   Zaki, S Mohd ^d   Ismail, R ^a,e  

^a SCHOOL OF HEALTH SCIENCES   (Malaysia)

^b SCHOOL OF PHYSICS   (Malaysia)

^c UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^d UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^e INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE INFORMM   (Malaysia)

Author keywords

Cancer; Cytochrome P450 (CYP) 2A6; Malaysia; Nicotine; Polymorphism

Indexed keywords

2 HYDROXYPHENYLACETIC ACID; COUMARIN; CYTOCHROME P450 2A6; DRUG METABOLITE; NICOTINE; OXIDOREDUCTASE; UMBELLIFERONE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CANCER; CANCER SUSCEPTIBILITY; CHINESE; CONTROLLED STUDY; CYP2A6 GENE; ETHNIC DIFFERENCE; ETHNIC GROUP; FEMALE; GENE; GENE DUPLICATION; GENE FREQUENCY; GENETIC POLYMORPHISM; HUMAN; INDIAN; LIVER TOXICITY; MALAYSIA; MALE; NORMAL HUMAN; PHARMACOGENETICS; POLYMERASE CHAIN REACTION; SMOKING; STATISTICAL SIGNIFICANCE;

ADULT; CHINA; COHORT STUDIES; CYTOCHROME P-450 ENZYME SYSTEM; DATABASES, GENETIC; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INDIA; MALAYSIA; MALE; POLYMORPHISM, GENETIC; SMOKING;

EID: 33746865554     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250600715932     Document Type: Article

References (26)

1. Ariyoshi N, Sawamura Y, Kamataki T. 2001. A novel single nucleotide polymorphism altering stability and activity of CYP2A6. Biochemical and Biophysical Research Communications 281:810-814.
2. Birnboim HC, Doly J. 1979. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Research 7:1513-1523.
3. Burns GW. 1980. Population genetics. In: The science of genetics: An introduction to heredity, 4th edn. London: Collier Macmillan. pp 317-340.
4. Garcia-Barcelo M, Chow LY, Chiu HF, Wing YK, Lee DT, Lam KL, Waye MM. 2000. Genetic analysis of the CYP2D6 locus in a Hong Kong Chinese population. Clinical Chemistry 46:18-23.
5. Hadidi H, Zahlsen K, Idle JR, Cholerton S. 1997. A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin. Food Chemistry and Toxicology 35:903-907.
6. Hoffmann D, Melikian A, Adams JD, Brunnemann KD, Haley NJ. 1985. New aspects of tobacco carcinogenesis. Carcinogens Comprehensive Survey 8:239-256.
7. Ismail R, Teh LK. 2001. Genetic polymorphism of CYP2D6: Malaysian Indians have the highest frequency for CYP2D6*4 in Asia. European Journal of Clinical Pharmacology 57(8):617-618.
8. Ismail R, Teh LK, Amir J, Alwi Z, Lopez CG. 2003. Genetic polymorphism of CYP2D6 in Chinese subjects in Malaysia. Journal of Clinical Pharmacology and Therapy 28(4):279-284.
9. London S, Idle JR, Daly AK, Coetzee GA. 1999. Genetic variation of CYP2A6, smoking, and risk of cancer. Lancet 353:898-899.
10. Muthiah YD, Lee WL, The LK, Ong CE, Ismail R. 2005. Genetic polymorphisms of CYP2C8 in three Malaysian ethnics: CYP2C8*2 and CYP2C8*3 are found in Malaysian Indians. Journal of Clinical Pharmacy and Therapeutics 30(5):487-490.
11. Nunoya KI, Yokoi T, Kimura K, Inoue K, Kodama T, Funayama M, Nagashima K, Funae Y, Green C, Kinoshita M, Kamataki T. 1998. A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502). Pharmacogenetic 8:239-249.
12. Oscarson M, Gullsten H, Rautio A, et al. 1998. Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase. FEBS Letters 438:201-205.
13. Oscarson M, McLellan RA, Gullsten H, et al. 1999a. Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population. FEBS Letters 448:105-110.
14. Oscarson M, McLellan RA, Gullsten H, et al. 1999b. Identification and characterization of novel polymorphisms in the CYP2A locus: implication for nicotine metabolism. FEBS Letters 460:321-327.
15. Patten CJ, Smith TJ, Freisen MJ, Tynes RE, Yang CS, Murphy SE. 1997. Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N′-nitrosonornicotine α-hydroxylation by human liver microsomes. Carcinogenesis 18:1623-1630.
16. Pianezza ML, Sellers EM, Tyndale RF. 1998. Nicotine metabolism defect reduces smoking. Nature 393:750.
17. Rautio A, Kraul H, Kojo A, Salmela E, Pelkonen O. 1992. Interindividual variability of coumarin 7-hydroxylation in healthy individuals. Pharmacogenetics 2:227-233.
18. Sadeque AJM, Fisher MB, Korzekwa KR, Gonzalez FJ, Rettie AE. 1997. Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid. Journal of Pharmacology and Experimental Therapy 283:672-698.
19. Schoedel KA, Hoffmann EB, Rao Y, Sellers EM, Tyndale RF. 2004. Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. Pharmacogenetics 14:615-626.
20. Shimada T, Yamazaki H, Guengerich FP. 1996. Ethnic-related differences in coumarin 7-hydroxylation activity catalyzed by cytochrome P2402A6 in liver microsomes of Japanese and Caucasians populations. Xenobiotica 26:395-403.
21. Teh LK, Ismail R, Yusoff R, Hussein A, Isa MN, Rahman AR. 2001. Heterogeneity of the CYP2D6 gene among Malays in Malaysia. Journal of Clinical Pharmacology and Therapy 26(3):205-211.
22. Tyndale RF, Sellers EM. 2002. Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. Therapeutic Drug Monitoring 24:163-171.
23. Wang J, Pitarque M, Ingelman-Sundberg M. 2006. 3′-UTR polymorphism in the human CYP2A6 gene effects mRNA stability and enzyme expression. Biochemistry and Biophysics Research Communications 340:491-497.
24. Xu P, Huang SL, Zhu RH, Han XM, Zhou HH. 2002. Phenotypic polymorphism of CYP2A6 activity in a Chinese population. European Journal of Clinical Pharmacology 58:333-337.
25. Yamazaki H, Inui Y, Yun CH, Guengerich FP, Shimada T. 1992. Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco related nitrosamines in human liver microsomes. Carcinogenesis 13:1789-1794.
26. Yoshida R, Nakajima M, Watanabe Y, Tack J, Yokoi T. 2002. Genetic polymorphism in human CYP2A6 gene causing impaired nicotine metabolism. British Journal of Clinical Pharmacology 54:511-517.