Phenotypic polymorphism of CYP2A6 activity in a Chinese population

European Journal of Clinical Pharmacology

Volumn 58, Issue 5, 2002, Pages 333-337

  Xu, Ping ^a   Huang, Song Lin ^a   Zhu, Rong Hua ^a   Han, Xing Mei ^a   Zhou, Hong Hao ^a  

^a Central South University   (China)

Author keywords

CYP2A6; Phenotype; Phenotypic polymorphism

Indexed keywords

COUMARIN; CYTOCHROME P450 2A6; UMBELLIFERONE;

ADULT; ARTICLE; CHINA; CONFIDENCE INTERVAL; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EXCRETION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME POLYMORPHISM; FEMALE; HUMAN; HUMAN EXPERIMENT; INTRASPECIFIC VARIATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RESIDUE ANALYSIS; STATISTICAL SIGNIFICANCE; URINARY EXCRETION;

ADOLESCENT; ADULT; ARYL HYDROCARBON HYDROXYLASES; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; FEMALE; HUMANS; MALE; MIXED FUNCTION OXYGENASES; PHENOTYPE; POLYMORPHISM, GENETIC; UMBELLIFERONES;

EID: 0036373739     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-002-0480-3     Document Type: Article

References (40)

1. P450 superfamily update on new sequences, gene mapping, accession numbers and nomenclature
2. Role of human cytochrome P450 2A6 in C-oxidation of nicotine
3. Characterization of CYP2A6 involved in 3′-hydroxylation of cotinine in human liver microsomes
4. Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes
5. Interindividual variability of coumarin 7-hydroxylation in healthy volunteers
6. Comparison of a novel thin-layer chromatographic-fluorescence detection with a spectrofluorometric method for the determination of 7-hydroxy-coumarin in human urine
7. Interindividual variability of coumarin 7-hydroxylation in a Turkish population
8. CYP2A6 gene deletion reduces susceptibility to lung cancer
9. Duplications and defects in the CYP2A6 gene: Identification, genotyping, and in vivo effects on smoking
10. Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans
11. Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase
12. A single amino acid substitution (Leu 160 His) in cytochrome P450 CYP2A6 cause switching from 7-hydroxylation to 3-hydroxylation of coumarin
13. Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P450 2A6 in liver microsomes of Japanese and Caucasian populations
14. A genetic polymorphism in coumarin 7-hydroxylation: Sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
15. CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis
16. Identification and characterization of novel polymorphisms in the CYP2A locus: Implications for nicotine metabolism
17. Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population
18. The significance of the homozygous CYP2A6 deletion on nicotine metabolism: A new genotyping method of CYP2A6 using a single PCR-RFLP
19. Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population
20. Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: Implications for interindividual differences in nicotine metabolism
21. Nicotine metabolism and CYP2A6 allele frequencies in Koreans
22. Mouse steroid 15α-hydroxylase gene family: Identification of type? P450 15α as coumarin 7-hydroxylase
23. Rapid and sensitive determination of coumarin and 7-hydroxycoumarin and its glucuronide conjugate in urine and plasma by high-performance liquid chromatograph
24. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine
25. Determination of CYP1A2 and NAT2 phenotypes in human population by analysis of caffeine urinary metabolites
26. Evaluation of two assumption: Single straight line and single normal distribution
27. Analysis of coumarin and its urinary metabolites by high-performance liquid chromatograph
28. Comparison of the metabolism and disposition of coumarin in the rat and marmoset (Callithrix jacchus)
29. Pharmacokinetics of coumarin and its 7-hydroxy-metabolites upon intravenous and peroral administration of coumarin in man
30. First-pass effect of coumarin in man
31. The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds
32. Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6
33. Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity
34. Sensitive high-performance liquid chromatographic method for the determination of coumarin in plasma
35. Therapeutic concentration of coumarin and predicted dosage regimens
36. Genetic analysis of the S-mephenytoin polymorphism in a Chinese population
37. Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans
38. Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans
39. Genetic variation of CYP2A6, smoking, and risk of cancer
40. An improved assay shows no association between the CYP2A6 gene and cigarette smoking behaviour