Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors

Journal of Neurophysiology

Volumn 81, Issue 4, 1999, Pages 1881-1888

  Holt, Jeffrey R ^a,b   Johns, David C ^c   Wang, Sam ^a,b   Chen, Zheng Yi ^a   Dunn, Robert J ^d   Marban, Eduardo ^c   Corey, David P ^a,b,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MONTREAL GENERAL HOSPITAL   (Canada)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; GENE PRODUCT; GREEN FLUORESCENT PROTEIN; ION CHANNEL; PROTEIN;

ADENO ASSOCIATED VIRUS; ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL FUNCTION; EXPRESSION VECTOR; GENE TRANSFER; HERPES SIMPLEX VIRUS; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033022208     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1999.81.4.1881     Document Type: Article

References (32)

1. BREAKEFIELD, X., JACOBS, A., AND WANG, S. Genetic engineering for CNS regeneration. In: CNS Regeneration: Basic Science and Clinical Applications. San Diego, CA: Academic, 1999, p. 251-291.
2. BYRNES, A. P., WOOD, M.J.A., AND CHARLTON, H. M. Role of T cells in inflammation caused by adenovirus vectors in the brain. Gene Ther. 3: 644-651, 1996.
3. CHIOCCA, S. AND COTTON, M. Characteristics of adenovirus vectors. In: Gene Therapy for Neurological Disorders and Brain Tumors. Totowa, NJ: Humana, 1998, p. 39-52.
4. DAZERT, S., BATTAGLIA, A., AND RYAN, A. F. Transfection of neonatal rat cochlear cells in vitro with an adenovirus vector. Int. J. Dev. Neurosci. 15: 595-600, 1997.
5. DENK, W. AND WEBB, W. W. Forward and reverse transduction at the limit of sensitivity studied by correlating electrical and mechanical fluctuations in frog saccular hair cells. Hear. Res. 60: 89-102, 1992.
6. DERBY, M. L., SENA-ESTEVES, M., BREAKEHELD, X. O., AND COREY, D. P. Gene transfer into the mammalian inner ear: A comparison study of three viral vectors. Hear. Res. In press.
7. FRAEFEL, C., SONG, S., LIM, F., LANG, P., YU, L., WANG, Y., WILD, P., AND GELLER, A. Helper-virus free transfer of herpes simplex virus type 1 plasmid vectors into neural cell. J. Virol. 70: 7190-7197, 1996
8. FUCHS, P. A. AND EVANS, M. G. Potassium currents in hair cells isolated from the cochlea of the chick. J. Physiol. (Lond.) 429: 529-551, 1990.
9. GOLDSTEIN, D. J. AND WELLER, S. K. Herpes simplex virus type-1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 insertion mutant. J. Virol. 62: 196-205, 1988.
10. GOODMAN, M. B. AND ART, J. J. Positive feedback by a potassium-selective inward rectifier enhances tuning in vertebrate hair cells. Biophys. J. 71: 430-442, 1996.
11. HARDY, S., KITAMURA, M., HARRIS-STANSIL, T., DAI, Y., AND PHIPPS, M. L. Construction of adenovirus vectors through Cre-lox recombination. J. Virol. 71: 1842-1849, 1997.
12. HOLT, J. R., COREY, D. P., AND EATOCK, R. A. Mechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ. J. Neurosci. 17: 8739-8748, 1997.
13. HOLT, J. R. AND EATOCK, R. A. Inwardly rectifying currents of saccular hair cells from the leopard frog. J. Neurophysiol. 73: 1484-1502, 1995.
14. HOLT, J. R., RÜSCH, A., VOLLRATH, M. A., AND EATOCK, R. A. The frequency dependence of receptor potentials in hair cells of the mouse utricle. Prim. Sen. Neuron. 2: 233-242, 1998.
15. JOHNS, D. C., MARX, R., MAINS, R. E., O'ROURKE, B., AND MARBAN, E. Inducible genetic suppression of neuronal excitability. J. Neurosci. In press.
16. JOHNS, D. C., NUSS, H. B., CHIAMNIMONVAT, N., RAMZA, B. M., MARBAN, E., AND LAWRENCE, J. H. Adenovirus-mediated expression of a voltage-gated potassium channel in vitro (rat cardiac myocytes) and in vivo (rat liver). A novel strategy for modifying excitability. J. Clin. Invest. 96: 1152-1158, 1995.
17. JOHNSTON, K. M., JACOBY, D. R., PECHAN, P. A., FRAEFEL, C. F., BORGHESANI, P., SUBACK, D., DUNN, R. J., SMITH, F. I., AND BREAKEFIELD, X. O. HSV/ AAV hybrid amplicon vectors extend transgene expression in human glioma cells. Hum. Gene Ther. 8: 359-370, 1997.
18. KACHAR, B., BATTAGLIA, A., AND FEX, J. Compartmentalized vesicular traffic around the hair cell cuticular plate. Hear. Res. 107: 102-112, 1997.
19. KOCHANEK, S., CLEMENS, P. R., MITANI, K., CHEN, H. H., CHAN, S., AND CASKEY, C. T. A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc. Natl. Acad. Sci. USA 93: 5731-5736, 1996.
20. KUMAR-SINOH, R. AND CHAMBERLAIN, J. S. Encapsidated adenovirus minichromosomes allow delivery and expression of a 14 kb dystrophin cDNA to muscle cells. Hum. Mol. Genet. 5: 913-921, 1996.
21. LALWANI, A. K., WALSH, B. J., REILLY, P. G., MUZYCZKA, N., AND MHATRE, A. N. Development of in vivo gene therapy for hearing disorders: introduction of adeno-associated virus into the cochlea of the guinea pig. Gene Ther. 3: 588-592, 1996.
22. MCBRIDE, D. W. AND HAMILL, O. P. A fast pressure-clamp technique for studying mechanogated channels. In: Single-Channel Recording. New York: Plenum, 1995, p. 329-340.
23. + channel cloned from the chick inner ear. J. Biol. Chem. 270: 19238-19245, 1995.
24. PEEL, A. L., ZOLOTHUKIN, S., SCHRIMSHER, G. W., MUZYCZKA, N., AND REIER, P. J. Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell-type specific promoters. Gene Ther. 4: 16-24, 1997.
25. RAPHAEL, Y., FRISANCHO, J. C., AND ROESSLER, B. J. Adenoviral-mediated gene transfer into guinea pig cochlear cells in vivo. Neurosci. Lett. 207: 137-141, 1996.
26. RÜSCH, A. AND EATOCK, R. A. A delayed rectifier conductance in type I hair cells of the mouse utricle. J. Neurophysiol. 76: 995-1004, 1996a.
27. RÜSCH, A. AND EATOCK, R. A. Voltage responses of mouse utricular hair cells to injected currents. Ann. NY Acad. Sci. 781: 71-84, 1996b.
28. RÜSCH, A., LYSAKOWSKI, A., AND EATOCK, R. A. Postnatal development of type I and type II hair cells in the mouse utricle: acquisition of voltage-gated conductances and differentiated morphology. J. Neurosci. 18: 7487-7501, 1998.
29. SCHIEDNER, G., MORRAL, N., PARKS, R. J., WU, Y., KOOPMANS, S. C., LANGSTON, C., GRAHAM, F. L., BEAUDET, A. L., AND KOCHANEK, S. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nat. Genet. 18: 180-183, 1998.
30. SUGIHARA, I. AND FURUKAWA, T. Inwardly rectifying currents in hair cells and supporting cells in the goldfish sacculus. J. Physiol. (Lond.) 495: 665-679, 1996.
31. WEISS, M. A., FRISANCHO, J. C., ROESSLER, B. J., AND RAPHAEL, Y. Viral-mediated gene transfer in the cochlea. Int. J. Dev. Neurosci. 15: 577-583, 1998.
32. ZOLOTUKHIN, S., POTTER, M., HAUSWIRTH, W. W., GUY, J., AND MUZYCZKA, N. A "humanized" greeen fluorescent protein cDNA adapted for high level expression in mammalian cells. J. Virol. 70: 4646-4654, 1996.