Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway

Journal of Steroid Biochemistry and Molecular Biology

Volumn 100, Issue 4-5, 2006, Pages 107-116

  O'Kelly, James ^a   Uskokovic, Milan ^b   Lemp, Nathan ^a   Vadgama, Jay ^c   Koeffler, H Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

^c CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

Mammalian target of rapamycin; Protein translation; Vitamin D

Indexed keywords

1,25 DIHYDROXY 21 (3 HYDROXY 3 METHYLBUTYL) 23 YNE 26,27 HEXAFLUORO 19 NORCOLECALCIFEROL; 1,25 DIHYDROXY 21 (3 HYDROXY 3 METHYLBUTYL) 23 YNE 26,27 HEXAFLUOROCOLECALCIFEROL; COLECALCIFEROL; COLECALCIFEROL DERIVATIVE; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN KINASE B; S6 KINASE; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DEPHOSPHORYLATION; DRUG POTENCY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; ONCOGENE; PROTEIN SYNTHESIS; TUMOR GROWTH;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLECALCIFEROL; EUKARYOTIC INITIATION FACTOR-4E; HUMANS; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; NEOPLASMS; PHOSPHOPROTEINS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 33746818698     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2006.04.003     Document Type: Article

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