Oral gene delivery: Strategies to improve stability of pDNA towards intestinal digestion

Journal of Drug Targeting

Volumn 14, Issue 5, 2006, Pages 311-319

  Loretz, Brigitta ^a   Föger, Florian ^a   Werle, Martin ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Chitosan; DNA vaccines; DNase inhibitors; Enzymatic degradation; Gene therapy

Indexed keywords

AURINTRICARBOXYLIC ACID; CHITOSAN; CYSTEINE; DEOXYRIBONUCLEASE I; DODECYL SULFATE SODIUM; EDETIC ACID; ENZYME INHIBITOR; PLASMID DNA; POLYACRYLIC ACID;

ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; DIGESTION; DRUG STABILITY; ENZYME ACTIVITY; ENZYME DEGRADATION; GASTROINTESTINAL SECRETION; GENE DELIVERY SYSTEM; INHIBITION KINETICS; INTESTINE CELL; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; SWINE; TRANSGENE;

ADMINISTRATION, ORAL; CACO-2 CELLS; CHITOSAN; DEOXYRIBONUCLEASE I; EDETIC ACID; GASTRIC JUICE; GENE THERAPY; HUMANS; INTESTINES; PLASMIDS;

EID: 33746786870     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860600823766     Document Type: Article

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