Stability of polycationic complexes of an antisense oligonucleotide in rat small intestine homogenates

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 55, Issue 1, 2003, Pages 19-26

  González Ferreiro, María ^a   Crooke, Rosanne M ^b   Tillman, Lloyd ^b   Hardee, Gregory ^b   Bodmeier, Roland ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

Antisense oligonucleotide; Capillary gel electrophoresis; Complex; Nuclease metabolism; Polycationic carriers; Tissue homogenates

Indexed keywords

ALICAFORSEN; ANTISENSE OLIGONUCLEOTIDE; ENDONUCLEASE; NUCLEASE; PROTAMINE SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYMATIC DEGRADATION; GASTROINTESTINAL TRACT; GEL ELECTROPHORESIS; MALE; NONHUMAN; RAT; SMALL INTESTINE; ULTRAVIOLET RADIATION;

EID: 0037237658     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(02)00140-6     Document Type: Article

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