Influence of simulated microgravity on the activation of the small GTPase Rho involved in cytoskeletal formation - Molecular cloning and sequencing of bovine leukemia-associated guanine nucleotide exchange factor

BMC Biochemistry

Volumn 7, Issue , 2006, Pages

  Higashibata, Akira ^a,b   Imamizo Sato, Mari ^b,c   Seki, Masaya ^b,c   Yamazaki, Takashi ^a   Ishioka, Noriaki ^a,b  

^a JAPAN AEROSPACE EXPLORATION AGENCY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c Tsukuba Mitsui Building ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ACTIN FILAMENT; ARTICLE; CELL CULTURE; CYTOSKELETON; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; MICROGRAVITY; MOLECULAR CLONING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRESS FIBER; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; CATTLE; CELL LINE; CYTOSKELETON; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MOLECULAR SEQUENCE DATA; RHO GTP-BINDING PROTEINS; SEQUENCE ANALYSIS, DNA; STRESS FIBERS; WEIGHTLESSNESS;

BOS TAURUS;

EID: 33746622067     PISSN: 14712091     EISSN: 14712091     Source Type: Journal    
DOI: 10.1186/1471-2091-7-19     Document Type: Article

References (36)

1. Lewis ML, Reynolds JL, Cubano LA, Hatton JP, Lawless BD, Piepmeier EH: Spaceflight alters microtubules and increases apoptosis in human lymphocytes (Jurkat). Faseb J 1998, 12(11):1007-1018.
2. Gruener R, Roberts R, Reitstetter R: Reduced receptor aggregation and altered cytoskeleton in cultured myocytes after space-flight. Biol Sci Space 1994, 8(2):79-93.
3. Hughes-Fulford M, Nelson K, Blaug S, Summer CG, Lukefahr BD, Lewis ML: MC3T3 osteoblasts grown in microgravity on STS-56 have reduced cell growth, glucose utilization with altered actin cytoskeleton and increased prostaglandin synthesis. ASGSB Bulletin 1993, 7:31.
4. Grimm D, Bauer J, Kossmehl P, Shakibaei M, Schoberger J, Pickenhahn H, Schulze-Tanzil G, Vetter R, Eilles C, Paul M, Cogoli A: Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells. Faseb J 2002, 16(6):604-606.
5. Hirasaka K, Nikawa T, Yuge L, Ishihara I, Higashibata A, Ishioka N, Okubo A, Miyashita T, Suzue N, Ogawa T, Oarada M, Kishi K: Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-kappa B signaling. Biochim Biophys Acta 2005, 1743(1-2):130-140.
6. Li Z, Song Y, Ma Y, Wei H, Liu C, Huang J, Wang N, Sha J, Sakurai F: Influence of simulated microgravity on avian primordial germ cell migration and reproductive capacity. J Exp Zool 2002, 292(7):672-676.
7. Sarkar D, Nagaya T, Koga K, Nomura Y, Gruener R, Seo H: Culture in vector-averaged gravity under clinostat rotation results in apoptosis of osteoblastic ROS 17/2.8 cells. J Bone Miner Res 2000, 15(3):489-498.
8. Uva BM, Masini MA, Sturla M, Prato P, Passalacqua M, Giuliani M, Tagliafierro G, Strollo F: Clinorotation-induced weightlessness influences the cytoskeleton of glial cells in culture. Brain Res 2002, 934(2):132-139.
9. Woods CC, Banks KE, Gruener R, DeLuca D: Loss of T cell precursors after spaceflight and exposure to vector-averaged gravity. Faseb J 2003, 17(11):1526-1528.
10. Höger G, Gruener R: Cytoskeletal properties are sensitive to vector-free gravity. ASGSB Bulletin 1990, 4:55.
11. Hall A: Rho GTPases and the actin cytoskeleton. Science 1998, 279(5350):509-514.
12. Ridley AJ, Hall A: The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992, 70(3):389-399.
13. Settleman J: Getting in shape with Rho. Nat Cell Biol 2000, 2(1):E7-9.
14. Van Aelst L, D'Souza-Schorey C: Rho GTPases and signaling networks. Genes Dev 1997, 11(18):2295-2322.
15. Aspenstrom P: Effectors for the Rho GTPases. Curr Opin Cell Biol 1999, 11(1):95-102.
16. Cerione RA, Zheng Y: The Dbl family of oncogenes. Curr Opin Cell Biol 1996, 8(2):216-222.
17. Whitehead IP, Campbell S, Rossman KL, Der CJ: Dbl family proteins. Biochim Biophys Acta 1997, 1332(1):F1-23.
18. Zheng Y: Dbl family guanine nucleotide exchange factors. Trends Biochem Sci 2001, 26(12):724-732.
19. Fukuhara S, Chikumi H, Gutkind JS: Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. FEBS Lett 2000, 485(2-3):183-188.
20. Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA: Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. Proc Natl Acad Sci U S A 2000, 97(5):2145-2150.
21. Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ: Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA. J Biol Chem 2001, 276(29):27145-27151.
22. Hymer WC, Grindeland R, Farrington M, Fast T, Hayes C, Motter K, Patil L: Microgravity associated changes in pituitary growth hormone (GH) cells prepared from rats flown on Space Lab 3. Physiologist 1985, 28(6 Suppl):S197-8.
23. Cogoli A: Gravitational physiology of human immune cells: a review of in vivo, ex vivo and in vitro studies. J Gravit Physiol 1996, 3(1):1-9.
24. Cogoli A, Tschopp A: Lymphocyte reactivity during spaceflight. Immunol Today 1985, 6(1):1-4.
25. Cogoli A, Tschopp A, Fuchs-Bislin P: Cell sensitivity to gravity. Science 1984, 225(4658):228-230.
26. Kolber MA, Broschat KO, Landa-Gonzalez B: Cytochalasin B induces cellular DNA fragmentation. Faseb J 1990, 4(12):3021-3027.
27. Martin SJ, Cotter TG: Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL-60 cells. Cell Tissue Kinet 1990, 23(6):545-559.
28. Boonstra J: Growth factor-induced signal transduction in adherent mammalian cells is sensitive to gravity. Faseb J 1999, 13 Suppl:S35-42.
29. Schatteen H, Lewis ML, Chakrabarti A: Spaceflight and clinorotation cause cytoskeleton and mitochondria changes and increases in apoptosis in cultured cells. Acta Astronaut 2001, 49:399-418.
30. Zinovyeva M, Sveshnikova E, Visser J, Belyavsky A: Molecular cloning, sequence and expression pattern analysis of the mouse orthologue of the leukemia-associated guanine nucleotide exchange factor. Gene 2004, 337:181-188.
31. Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS: A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem 1999, 274(9):5868-5879.
32. Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G: Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science 1998, 280(5372):2112-2114.
33. Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC: p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science 1998, 280(5372):2109-2111.
34. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K: Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996, 273(5272):245-248.
35. Leung T, Chen XQ, Manser E, Lim L: The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol 1996, 16(10):5313-5327.
36. Bershadsky AD, Balaban NQ, Geiger B: Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol 2003, 19:677-695.