Strain difference in susceptibility to experimental autoimmune encephalomyelitis between Albino Oxford and Dark Agouti rats correlates with disparity in production of IL-17, but not nitric oxide

Journal of Neuroscience Research

Volumn 84, Issue 2, 2006, Pages 379-388

  Miljkovic, Djordje ^a   Stosic Grujicic, Stanislava ^a   Markovic, Milos ^b   Momcilovic, Miljana ^a   Ramic, Zorica ^b   Maksimovic Ivanic, Danijela ^a   Mijatovic, Sanja ^a   Popadic, Dusan ^b   Cvetkovic, Ivana ^a   Mostarica Stojkovic, Marija ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Carbonyl iron; EAE; IL 17; Nitric oxide

Indexed keywords

CARBONYL IRON; GAMMA INTERFERON; INTERLEUKIN 17; MYELIN BASIC PROTEIN; NITRIC OXIDE;

ALBINISM; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL ACTIVATION; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; LYMPH NODE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STRAIN DIFFERENCE;

ANIMALS; CELL PROLIFERATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; INTERFERON TYPE II; INTERLEUKIN-17; LYMPHOCYTES; MALE; NITRIC OXIDE; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD;

EID: 33746402398     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.20883     Document Type: Article

References (35)

1. Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. 2003. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278:1910-1914.
2. Bo L, Dawson T, Wesselingh S, Mork S, Choi S, Kong P, Hanley D, Trapp B. 1994. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 36:778-786.
3. Bogdan C. 1998. The multiplex function of nitric oxide in (auto)immunity. J Exp Med 187:1361-1365.
4. Cowden WB, Cullen FA, Staykova MA, Willenborg DO. 1998. Nitric oxide is a potential down-regulating molecule in autoimmune disease: inhibition of nitric oxide production renders PVG rats highly susceptible to EAE. J Neuroimmunol 88:1-8.
5. Drulovic J, Dujmovic I, Stojsavljevic N, Mesaros S, Andjelkovic S, Miljkovic D, Peric V, Dragutinovic G, Marinkovic J, Levic Z, Mostarica Stojkovic M. 2001. Uric acid levels in sera from patients with multiple sclerosis. J Neurol 248:121-126.
6. Fournie GJ, Cautain B, Xystrakis E, Damoiseaux J, Mas M, Lagrange D, Bernard lois Subra J-F, Pelletier L, Druet P, Saoudi A. 2001. Cellular and genetic factors involved in the difference between Brown Norway and Lewis rats to develop respectively type-2 and type-1 immune-mediated diseases. Immunol Rev 184:145-160.
7. Gold DP, Schroder K, Powell HC, Kelly CJ. 1997. Nitric oxide and the immunomodulation of experimental allergic encephalomyelitis. Eur J Immunol 27:2863-2869.
8. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6:1123-1132.
9. Hibbs JB, Taintor R, Vavrin Z, Rachlin E. 1989. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157:87-94.
10. Hoeve MA, Savage ND, de Boer T, Langenberg DML, de Waal Malefyt R, Ottenhoff THM, Verreck FAW. 2006. Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur J Immunol 36:661-670.
11. Ikeda M, Sato I, Matsunaga T, Takahashi M, Yuasa T, Murota S. 1995. Cyclic guanosine monophosphate (cGMP), nitrite and nitrate in the cerebrospinal fluid in meningitis, multiple sclerosis and Guillain-Barre syndrome. Intern Med 34:734-737.
12. Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201:233-240.
13. Levine S, Saltzman A. 1989. The hyperacute form of allergic encephalomyelitis produced in rats without the aid of pertussis vaccine. J Neuropathol Exp Neurol 48:255-262.
14. Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, Langer-Gould A, Strober S, Cannella B, Allard J, Klonowski P, Austin A, Lad N, Kaminski N, Galli SJ, Oksenberg JR, Raine CS, Heller R, Steinman L. 2002. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 8:500-508.
15. Lorentzen JC, Issazadeh S, Storch M, Mustafa MI, Lassman H, Linington C, Klareskog L, Olsson T. 1995. Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant. J Neuroimmunol 63:193-205.
16. Lukic ML, Mensah-Brown E, Galadari S, Shahin A. 2001. Lack of apoptosis of infiltrating cells as the mechanism of high susceptibility to EAE in DA rats. Dev Immunol 8:193-200.
17. Matusevicius D, Kivisakk P, He B, Kostulas N, Ozenci V, Fredrikson S, Link H. 1999. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 5:101-104.
18. Mostarica-Stojkovic M, Petrovic M, Lukic ML. 1982a. Cellular and genetic basis of the relative resistance to the induction of experimental allergic encephalomyelitis (EAE) in albino oxford (AO) rats. Adv Exp Med Biol 149:699-702.
19. Mostarica-Stojkovic M, Petrovic M, Lukic ML. 1982b. Resistance to the induction of EAE in AO rats: its prevention by the pre-treatment with cyclophosphamide or low dose of irradiation. Clin Exp Immunol 50:311-317.
20. Mostarica-Stojkovic M, Vukmanovic S, Ramic Z, Lukic ML. 1992. Evidence for target tissue regulation of resistance to the induction of experimental allergic encephalomyelitis in AO rats. Neuroimmunology 41:97-104.
21. Olsson T. 1995. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 144:245-268.
22. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6:1133-1141.
23. Segal BM. 2005. CNS chemokines, cytokines, and dendritic cells in autoimmune demyelination. J Neurol Sci 228:210-214.
24. Sospedra M, Martin R. 2005. Immunology of multiple sclerosis. Annu Rev Immunol 23:683-747.
25. Staykova MA, Cowden W, Willenborg DO. 2002. Macrophages and nitric oxide as the possible cellular and molecular basis for strain and gender differences in susceptibility to autoimmune central nervous system inflammation. Immunol Cell Biol 80:188-197.
26. Staykova MA, Paridaen JT, Cowden WB, Willenborg DO. 2005. Nitric oxide contributes to resistance of the Brown Norway rat to experimental autoimmune encephalomyelitis. Am J Pathol 166:147-157.
27. Stosic-Grujicic S, Ramic Z, Bumbasirevic V, Harhaji L, Mostarica-Stojkovic M. 2004. Induction of experimental autoimmune encephalomyelitis in Dark Agouti rats without adjuvant. Clin Exp Immunol 136:49-55.
28. Swanborg RH. 2001. Experimental autoimmune encephalomyelitis in the rat: lessons in T-cell immunology and auto reactivity. Immunol Rev 184:129-135.
29. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. 2006. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179-189.
30. Vukmanovic S, Mostarica Stojkovic M, Lukic ML. 1989. Experimental autoimmune encephalomyelitis in "low" and "high" interleukin 2 producer rats. I. Cellular basis of induction. Cell Immunol 121:237-246.
31. Vukmanovic S, Mostarica-Stojkovic M, Zalud I, Ramic Z, Lukic ML. 1990. Analysis of T cell subsets after induction of experimental autoimmune encephalomyelitis in susceptible and resistant strains of rats. J Neuroimmunol 27:63-69.
32. Wheeler RD, Owens T. 2005. The changing face of cytokines in the brain: perspectives from EAE. Curr Pharm Des 11:1031-1037.
33. Willenborg DO, Staykova MA, Cowden WB. 1999. Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review. J Neuroimmunol 100:21-35.
34. Zielasek J, Jung S, Gold R, Liew FY, Toyka KV, Hartung HP. 1995. Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis. J Neuroimmunol 58:81-88.
35. Ziolkowska M, Koc A, Lusczykiewicz G, Ksiezopolska-Pietrzak K, Klimczak E, Chwalinska-Sadowska H, Maslinski W. 2000. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporine A-sensitive mechanism. J Immunol 164:2832-2828.