Cystic, mucin-producing neoplasms of the pancreas: the distinguishing features of mucinous cystic neoplasms and intraductal papillary mucinous neoplasms

Seminars in Diagnostic Pathology

Volumn 22, Issue 4, 2005, Pages 318-329

  Klimstra, David S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cyst; Intraductal; Mucinous; Pancreas; Papillary

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN; KERATIN; MUCIN;

ARTICLE; ASPIRATION BIOPSY; CANCER DIAGNOSIS; CANCER GRADING; CELL POLARITY; CELL PROLIFERATION; CLINICAL FEATURE; COLLOID CARCINOMA; CYST; CYSTADENOCARCINOMA; CYSTADENOMA; CYTOARCHITECTURE; CYTOLOGY; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; DYSPLASIA; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; FROZEN SECTION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; INVASIVE CARCINOMA; MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY; ONCOGENE K RAS; PANCREAS TUMOR; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RADIOGRAPHY; TUMOR VOLUME;

ADULT; AGED; CARCINOMA, PANCREATIC DUCTAL; CARCINOMA, PAPILLARY; CYSTS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; MUCINS; PANCREATIC NEOPLASMS; PROGNOSIS;

EID: 33746362590     PISSN: 07402570     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semdp.2006.04.005     Document Type: Article

References (87)

1. Compagno J., and Oertel J.E. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 69 (1978) 573-580
2. Albores-Saavedra J., Angeles-Angeles A., Nadji M., et al. Mucinous cystadenocarcinoma of the pancreas. Morphologic and immunocytochemical observations. Am J Surg Pathol 11 (1987) 11-20
3. Fukushima N., and Mukai K. Differential diagnosis between intraductal papillary-mucinous tumors and mucinous cystic tumors of the pancreas. Int J Surg Pathol 8 (2000) 271-278
4. Hruban RH, Pitman MB, Klimstra DS: Tumors of the Pancreas. Atlas of Tumor Pathology, 4th series, fascicle. Washington DC, American Registry of Pathology, in press
5. Solcia E., Capella C., and Kloppel G. Tumors of the pancreas. Atlas of Tumor Pathology. 3rd Series, fascicle 27 (2000), Armed Forces Institute of Pathology, Washington DC
6. Thompson L.D., Becker R.C., Przygodzki R.M., et al. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas. a clinicopathologic study of 130 cases. Am J Surg Pathol 23 (1999) 1-16
7. Zamboni G., Scarpa A., Bogina G., et al. Mucinous cystic tumors of the pancreas. clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol 23 (1999) 410-422
8. Wilentz R.E., Albores-Saavedra J., Zahurak M., et al. Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 23 (1999) 1320-1327
9. Bastid C., Sahel J., Sastre B., et al. Mucinous cystadenocarcinoma of the pancreas. Ultrasonographic findings in 5 cases. Acta Radiol 30 (1989) 45-47
10. Le Borgne J., de Calan L., Partensky C., and French Surgical Association. Cystadenomas and cystadenocarcinomas of the pancreas. a multiinstitutional retrospective study of 398 cases. Ann Surg 230 (1999) 152-161
11. Procacci C., Carbognin G., Accordini S., et al. CT features of malignant mucinous cystic tumors of the pancreas. Eur Radiol 11 (2001) 1626-1630
12. Fukushima N., and Mukai K. "Ovarian-type" stroma of pancreatic mucinous cystic tumor expresses smooth muscle phenotype. Pathol Int 47 (1997) 806-808
13. Izumo A., Yamaguchi K., Eguchi T., et al. Mucinous cystic tumor of the pancreas. immunohistochemical assessment of "ovarian-type stroma". Oncol Rep 10 (2003) 515-525
14. Ridder G.J., Maschek H., Flemming P., et al. Ovarian-like stroma in an invasive mucinous cystadenocarcinoma of the pancreas positive for inhibin. A hint concerning its possible histogenesis. Virchows Arch 432 (1998) 451-454
15. Warshaw A.L., and Rutledge P.L. Cystic tumors mistaken for pancreatic pseudocysts. Ann Surg 205 (1987) 393-398
16. Sarr M.G., Carpenter H.A., Prabhakar L.P., et al. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas. can one reliably differentiate benign from malignant (or premalignant) neoplasms?. Ann Surg 231 (2000) 205-212
17. Adsay N.V., Longnecker D.S., and Klimstra D.S. Pancreatic tumors with cystic dilatation of the ducts. intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms. Semin Diagn Pathol 17 (2000) 16-30
18. Campman S.C., Fajardo M.A., Rippon M.B., et al. Adenosquamous carcinoma arising in a mucinous cystadenoma of the pancreas. J Surg Oncol 64 (1997) 159-162
19. Lane Jr. R.B., and Sangueza O.P. Anaplastic carcinoma occurring in association with a mucinous cystic neoplasm of the pancreas. Arch Pathol Lab Med 121 (1997) 533-535
20. Mentes A., and Yuce G. Osteoclast-type giant cell tumor of the pancreas associated with mucinous cystadenoma. Eur J Surg Oncol 19 (1993) 84-86
21. Wenig B.M., Albores-Saavedra J., Buetow P.C., et al. Pancreatic mucinous cystic neoplasm with sarcomatous stroma. a report of three cases. Am J Surg Pathol 21 (1997) 70-80
22. van den Berg W., Tascilar M., Offerhaus G.J., et al. Pancreatic mucinous cystic neoplasms with sarcomatous stroma. molecular evidence for monoclonal origin with subsequent divergence of the epithelial and sarcomatous components. Mod Pathol 13 (2000) 86-91
23. Kosmahl M., Pauser U., Anlauf M., et al. Pancreatic ductal adenocarcinomas with cystic features. neither rare nor uniform. Mod Pathol 18 (2005) 1157-1164
24. Zamboni G., Kloppel G., Hruban R.H., et al. Mucinous cystic neoplasms of the pancreas. In: Hamilton S.R., and Aaltonen L.A. (Eds). World Heath Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System (2000), IARC Press, Lyon 234-236
25. Ohhashi K., Murakami Y., and Takekoshi T. Four cases of "mucin producing" cancer of the pancreas on specific findings of the papilla of Vater. (Abstr). Prog Diagn Endosc 20 (1982) 348-351
26. Adsay N.V., Adair C.F., Heffess C.S., et al. Intraductal oncocytic papillary neoplasms of the pancreas. Am J Surg Pathol 20 (1996) 980-994
27. Albores-Saavedra J., Sheahan K., O'Riain C., et al. Intraductal tubular adenoma, pyloric type, of the pancreas. additional observations on a new type of pancreatic neoplasm. Am J Surg Pathol 28 (2004) 233-238
28. Tajiri T., Tate G., Inagaki T., et al. Intraductal tubular neoplasms of the pancreas. histogenesis and differentiation. Pancreas 30 (2005) 115-121
29. Tajiri T., Tate G., Kunimura T., et al. Histologic and immunohistochemical comparison of intraductal tubular carcinoma, intraductal papillary-mucinous carcinoma, and ductal adenocarcinoma of the pancreas. Pancreas 29 (2004) 116-122
30. Inagaki M., Maguchi M., Kino S., et al. Mucin-producing tumors of the pancreas. clinicopathological features, surgical treatment, and outcome. J Hepatobiliary Pancreat Surg 6 (1999) 281-285
31. Nagai E., Ueki T., Chijiiwa K., et al. Intraductal papillary mucinous neoplasms of the pancreas associated with so-called "mucinous ductal ectasia". Histochemical and immunohistochemical analysis of 29 cases. Am J Surg Pathol 19 (1995) 576-589
32. Adsay N.V., Conlon K.C., Zee S.Y., et al. Intraductal papillary-mucinous neoplasms of the pancreas. an analysis of in situ and invasive carcinomas in 28 patients. Cancer 94 (2002) 62-77
33. D'Angelica M., Brennan M.F., Suriawinata A.A., et al. Intraductal papillary mucinous neoplasms of the pancreas. an analysis of clinicopathologic features and outcome. Ann Surg 239 (2004) 400-408
34. Falconi M., Salvia R., Bassi C., et al. Clinicopathological features and treatment of intraductal papillary mucinous tumour of the pancreas. Br J Surg 88 (2001) 376-381
35. Longnecker D.S., Adler G., Hruban R.H., et al. Intraductal papillary-mucinous neoplasms of the pancreas. In: Hamilton S.R., and Aaltonen L.A. (Eds). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System (2000), IARC Press, Lyon 237-240
36. Paal E., Thompson L.D., Przygodzki R.M., et al. A clinicopathologic and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature. Mod Pathol 12 (1999) 518-528
37. Sessa F., Solcia E., Capella C., et al. Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms. an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Arch 425 (1994) 357-367
38. Kobari M., Egawa S., Shibuya K., et al. Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes. differences in clinical characteristics and surgical management. Arch Surg 134 (1999) 1131-1136
39. Salvia R., Fernandez-del Castillo C., Bassi C., et al. Main-duct intraductal papillary mucinous neoplasms of the pancreas. clinical predictors of malignancy and long-term survival following resection. Ann Surg 239 (2004) 678-685 discussion 685-687
40. Terris B., Ponsot P., Paye F., et al. Intraductal papillary mucinous tumors of the pancreas confined to secondary ducts show less aggressive pathologic features as compared with those involving the main pancreatic duct. Am J Surg Pathol 24 (2000) 1372-1377
41. Yamaguchi K., and Tanaka M. Mucin-hypersecreting tumor of the pancreas with mucin extrusion through an enlarged papilla. Am J Gastroenterol 86 (1991) 835-839
42. Koito K., Namieno T., Ichimura T., et al. Mucin-producing pancreatic tumors. comparison of MR cholangiopancreatography with endoscopic retrograde cholangiopancreatography. Radiology 208 (1998) 231-237
43. Taouli B., Vilgrain V., Vullierme M.P., et al. Intraductal papillary mucinous tumors of the pancreas. helical CT with histopathologic correlation. Radiology 217 (2000) 757-764
44. Furukawa T., Kloppel G., Volkan Adsay N., et al. Classification of types of intraductal papillary-mucinous neoplasm of the pancreas. a consensus study. Virchows Arch 447 (2005) 794-799
45. Sohn T.A., Yeo C.J., Cameron J.L., et al. Intraductal papillary mucinous neoplasms of the pancreas. an increasingly recognized clinicopathologic entity. Ann Surg 234 (2001) 313-321 discussion 321-322
46. Adsay N.V., Pierson C., Sarkar F., et al. Colloid (mucinous noncystic) carcinoma of the pancreas. Am J Surg Pathol 25 (2001) 26-42
47. Seidel G., Zahurak M., Iacobuzio-Donahue C., et al. Almost all infiltrating colloid carcinomas of the pancreas and periampullary region arise from in situ papillary neoplasms. a study of 39 cases. Am J Surg Pathol 26 (2002) 56-63
48. Adsay N.V., Merati K., Basturk O., et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms. delineation of an "intestinal" pathway of carcinogenesis in the pancreas. Am J Surg Pathol 28 (2004) 839-848
49. Patel S.A., Adams R., Goldstein M., et al. Genetic analysis of invasive carcinoma arising in intraductal oncocytic papillary neoplasm of the pancreas. Am J Surg Pathol 26 (2002) 1071-1077
50. Nakayama Y., Inoue H., Hamada Y., et al. Intraductal tubular adenoma of the pancreas, pyloric gland type. a clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol 29 (2005) 607-616
51. Nakagohri T., Asano T., Kenmochi T., et al. Long-term surgical outcome of noninvasive and minimally invasive intraductal papillary mucinous adenocarcinoma of the pancreas. World J Surg 26 (2002) 1166-1169
52. Chari S.T., Yadav D., Smyrk T.C., et al. Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas. Gastroenterology 123 (2002) 1500-1507
53. Fukushima N., Mukai K., Sakamoto M., et al. Invasive carcinoma derived from intraductal papillary-mucinous carcinoma of the pancreas. clinicopathologic and immunohistochemical study of eight cases. Virchows Arch 439 (2001) 6-13
54. Gigot J.F., Deprez P., Sempoux C., et al. Surgical management of intraductal papillary mucinous tumors of the pancreas. the role of routine frozen section of the surgical margin, intraoperative endoscopic staged biopsies of the Wirsung duct, and pancreaticogastric anastomosis. Arch Surg 136 (2001) 1256-1262
55. Maire F., Hammel P., Terris B., et al. Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma. Gut 51 (2002) 717-722
56. Adsay N.V., Merati K., Andea A., et al. The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas. differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis. Mod Pathol 15 (2002) 1087-1095
57. Luttges J., Zamboni G., Longnecker D., et al. The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma. Am J Surg Pathol 25 (2001) 942-948
58. Khalifeh I., Basturk O., and Zamboni G. Villous-intestinal differentiation and progression to colloid carcinoma, characteristic of a major subset of IPMNs, are not features of mucinous cystic neoplasms. Mod Pathol 18 (2005) 281A
59. Terris B., Dubois S., Buisine M.P., et al. Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions. J Pathol 197 (2002) 632-637
60. Luttges J., Feyerabend B., Buchelt T., et al. The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 26 (2002) 466-471
61. Yonezawa S., Taira M., Osako M., et al. MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas. Pathol Int 48 (1998) 319-322
62. Albores-Saavedra J., Nadji M., Henson D.E., et al. Entero-endocrine cell differentiation in carcinomas of the gallbladder and mucinous cystadenocarcinomas of the pancreas. Pathol Res Pract 183 (1988) 169-175
63. Terada T., Ohta T., Kitamura Y., et al. Endocrine cells in intraductal papillary-mucinous neoplasms of the pancreas. A histochemical and immunohistochemical study. Virchows Arch 431 (1997) 31-36
64. Flejou J.F., Boulange B., Bernades P., et al. p53 protein expression and DNA ploidy in cystic tumors of the pancreas. Pancreas 13 (1996) 247-252
65. Izawa T., Obara T., Tanno S., et al. Clonality and field cancerization in intraductal papillary-mucinous tumors of the pancreas. Cancer 92 (2001) 1807-1817
66. Jimenez R.E., Warshaw A.L., Z'Graggen K., et al. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg 230 (1999) 501-509 discussion 509-511
67. Sasaki S., Yamamoto H., Kaneto H., et al. Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas. Oncol Rep 10 (2003) 21-25
68. Yoshizawa K., Nagai H., Sakurai S., et al. Clonality and K-ras mutation analyses of epithelia in intraductal papillary mucinous tumor and mucinous cystic tumor of the pancreas. Virchows Arch 441 (2002) 437-443
69. Fujii H., Inagaki M., Kasai S., et al. Genetic progression and heterogeneity in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol 151 (1997) 1447-1454
70. Kawahira H., Kobayashi S., Kaneko K., et al. p53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy. Hepatogastroenterology 47 (2000) 973-977
71. Satoh K., Shimosegawa T., Moriizumi S., et al. K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas. Pancreas 12 (1996) 362-368
72. Wada K. p16 and p53 gene alterations and accumulations in the malignant evolution of intraductal papillary-mucinous tumors of the pancreas. J Hepatobiliary Pancreat Surg 9 (2002) 76-85
73. Iacobuzio-Donahue C.A., Klimstra D.S., Adsay N.V., et al. Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas. comparison with conventional ductal adenocarcinomas. Am J Pathol 157 (2000) 755-761
74. Iacobuzio-Donahue C.A., Wilentz R.E., Argani P., et al. Dpc4 protein in mucinous cystic neoplasms of the pancreas. frequent loss of expression in invasive carcinomas suggests a role in genetic progression. Am J Surg Pathol 24 (2000) 1544-1548
75. Biankin A.V., Biankin S.A., Kench J.G., et al. Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. Gut 50 (2002) 861-868
76. House M.G., Guo M., Iacobuzio-Donahue C., et al. Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas. Carcinogenesis 24 (2003) 193-198
77. Hruban R.H., Takaori K., Klimstra D.S., et al. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 28 (2004) 977-987
78. Paye F., Sauvanet A., Terris B., et al. Intraductal papillary mucinous tumors of the pancreas. pancreatic resections guided by preoperative morphological assessment and intraoperative frozen section examination. Surgery 127 (2000) 536-544
79. Andea A.A., Cheng J., Lauwers G.Y., et al. Pancreatic intraepithelial neoplasia (PanIN) in pancreata involved by mucinous cystic neoplasms. Mod Pathol 15 (2002) 282A
80. Irie H., Yoshimitsu K., Aibe H., et al. Natural history of pancreatic intraductal papillary mucinous tumor of branch duct type. follow-up study by magnetic resonance cholangiopancreatography. J Comput Assist Tomogr 28 (2004) 117-122
81. Hara H., Suda K., and Oyama T. Cytologic study of noninvasive intraductal papillary-mucinous carcinoma of the pancreas. Acta Cytol 46 (2002) 519-526
82. Maire F., Couvelard A., Hammel P., et al. Intraductal papillary mucinous tumors of the pancreas. the preoperative value of cytologic and histopathologic diagnosis. Gastrointest Endosc 58 (2003) 701-706
83. Recine M., Kaw M., Evans D.B., et al. Fine-needle aspiration cytology of mucinous tumors of the pancreas. Cancer 102 (2004) 92-99
84. Layfield L.J., and Cramer H. Fine-needle aspiration cytology of intraductal papillary-mucinous tumors. a retrospective analysis. Diagn Cytopathol 32 (2005) 16-20
85. Shimizu M., Hirokawa M., Manabe T., et al. Cytologic findings in noninvasive intraductal papillary-mucinous carcinoma of the pancreas. A report of two cases. Acta Cytol 43 (1999) 243-246
86. Stelow E.B., Stanley M.W., Bardales R.H., et al. Intraductal papillary-mucinous neoplasm of the pancreas. The findings and limitations of cytologic samples obtained by endoscopic ultrasound-guided fine-needle aspiration. Am J Clin Pathol 120 (2003) 398-404
87. Warshaw A.L., Compton C.C., Lewandrowski K., et al. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 212 (1990) 432-443 discussion 444-445