Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas

Oncology Reports

Volumn 10, Issue 1, 2003, Pages 21-25

  Sasaki, Shigeru ^a   Yamamoto, Hiroyuki ^a   Kaneto, Hiroyuki ^a   Ozeki, Itaru ^a   Adachi, Yasuyo ^a   Takagi, Hideyasu ^a   Matsumoto, Takeshi ^a   Itoh, Hideto ^a   Nagakawa, Tatsuya ^b   Miyakawa, Hiroyuki ^b   Muraoka, Shunji ^b   Fujinaga, Akira ^b   Suga, Toshihiro ^b   Satoh, Masaaki ^a   Itoh, Fumio ^a   Endo, Takao ^a   Imai, Kohzoh ^a  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

^b Sapporo Kosei General Hospital   (Japan)

Author keywords

Immunohistochemistry; Intraductal papillary mucinous tumor; p16; p53; SMAD4

Indexed keywords

DNA BINDING PROTEIN; KI 67 ANTIGEN; PROTEIN P16INK4A; PROTEIN P53; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ADENOMA; ARTICLE; CANCER INVASION; CASE CONTROL STUDY; CELL TRANSFORMATION; COLLOID CARCINOMA; COMPARATIVE STUDY; DISEASE COURSE; ENZYME IMMUNOASSAY; GENETICS; HUMAN; HYPERPLASIA; METABOLISM; PANCREAS; PANCREAS CARCINOMA; PANCREAS TUMOR; PAPILLARY CARCINOMA; PATHOLOGY; SURVIVAL RATE;

ADENOCARCINOMA, MUCINOUS; ADENOMA; CARCINOMA, PANCREATIC DUCTAL; CARCINOMA, PAPILLARY; CASE-CONTROL STUDIES; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; DNA-BINDING PROTEINS; HUMANS; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; NEOPLASM INVASIVENESS; PANCREAS; PANCREATIC NEOPLASMS; SMAD4 PROTEIN; SURVIVAL RATE; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 1842575443     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.10.1.21     Document Type: Article

References (26)

1. Ohhashi K, Murakami Y and Takekoshi T: Four cases of 'mucin producing' cancer of the pancreas on specific findings of the papilla of Vater. Prog Diagn Endosc 20: 348-351, 1982.
2. Nagai E, Ueki T, Chijiiwa K, Tanaka M and Tsuneyoshi M: Intraductal papillary mucinous neoplasms of the pancreas associated with so-called 'mucinous ductal ectasia'. Histochemical and immunohistochemical analysis of 29 cases. Am J Surg Pathol 19: 576-589, 1995.
3. Loftus EV, Olivares-Pakzad BA, Batts KP, Adkins MC, Stephens DH, Sarr MG and Di Magno E: Intraductal papillary-mucinous tumors of the pancreas: clinicopathologic features, outcome and nomenclature. Gastroenterology 110: 1909-1918, 1996. (Pubitemid 26169229)
4. Azar C, van de Stadt J, Rickaert F, Deviere M, Baize M, Kloppel G, Gelin M and Cremer M: Intraductal papillary mucinous tumours of the pancreas: clinical and therapeutic issues in 32 patients. Gut 39: 457-464, 1996. (Pubitemid 26338538)
5. Fukushima N, Mukai K, Kanai Y, Hasebe T, Shimada K, Ozaki H, Kinoshita T and Kosuge T: Intraductal papillary tumors and mucinous cystic tumors of the pancreas: clinicopathologic study of 38 cases. Hum Pathol 28: 1010-1017, 1997. (Pubitemid 27388101)
6. Kimura W, Makuuchi M and Kuroda A: Characteristics and treatment of mucin-producing tumor of the pancreas. Hepatogastroenterology 45: 2001-2008, 1998. (Pubitemid 29055767)
7. Traverso LW, Peralta EA, Ryan JAJ and Kozarek RA: Intraductal neoplasms of the pancreas. Am J Surg 175: 426-432, 1998. (Pubitemid 28213460)
8. Fukushima N and Mukai K: Pancreatic neoplasms with abundant mucus production: emphasis on intraductal papillary-mucinous tumors and mucinous cystic tumors. Adv Anat Pathol 6: 65-77, 1999.
9. Paal E, Thompson LD, Przygodzki RM, Bratthauer GL and Heffessm CS: A clinicopathologic and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature. Mod Pathol 12: 518-528, 1999. (Pubitemid 29230614)
10. Yamaguchi K, Ogawa Y, Chijiiwa K and Tanaka M: Mucin-hypersecreting tumors of the pancreas: assessing the grade of malignancy preoperatively. Am J Surg 171: 427-431, 1996. (Pubitemid 26105212)
11. Rickaert F, Cremer M, Deviere J, Tavares L, Lambilliotte JP, Schroder S, Wurbs D and Kloppel G: Intraductal mucin-hypersecreting neoplasms of the pancreas. A clinicopathologic study of eight patients. Gastroenterology 101: 512-519, 1991.
12. Tian FZ, Myles J and Howard JM: Mucinous pancreatic ductal ectasia of latent malignancy: an emerging clinicopathologic entity. Surgery 111: 109-113, 1992.
13. Kloppel G, Solcia E, Longnecker DS, Capella C and Sobin LH: In: Histologic Typing of Tumours of the Exocrine Pancreas. Springer-Verlag, New York, 1996.
14. Sessa F, Solcia E, Capella C, Bonato M, Scarpa A, Zamboni G, Pellegata NS, Ranzani GN, Rickaert F and Kloppel G: Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Arch 425: 357-367, 1994.
15. Satoh K, Shimosegawa T, Moriizumi S, Koizumi M and Toyota T: K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas. Pancreas 12: 362-368, 1996.
16. Z'graggen K, Rivera JA, Compton CC, Pins M, Werner J, Fernandez-del Castillo C, Rattner DW, Lewandrowski KB, Rustgi AK and Warshaw AL: Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas. Ann Surg 226: 491-498, 1997.
17. Kondo H, Sugano K, Fukayama N, Hosokawa K, Ohkura H, Ohtsu A, Mukai K and Yoshida S: Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas. Cancer 79: 900-905, 1997. (Pubitemid 27089872)
18. Mulligan NJ, Yang S, Andry C, Klein M and O'Brien MJ: The role of p21ras in pancreatic neoplasia and chronic pancreatitis. Hum Pathol 30: 602-610, 1999. (Pubitemid 29266716)
19. Kaino M, Kondoh S, Okita S, Hatano S, Shiraishi K, Kaino S and Okita K: Detection of K-ras and p53 gene mutations in pancreatic juice for the diagnosis of intraductal papillary mucinous tumors. Pancreas 18: 294-299, 1999. (Pubitemid 29149209)
20. Satoh K, Sasano H, Shimosegawa T, Koizumi M, Yamazuki T, Mochizuki F, Kobayashi N, Okano T, Toyota T and Sawai T: An immunohistochemical study of the c-erbB-2 oncogene product in intraductal mucin-hypersecreting neoplasms and in ductal cell carcinomas of the pancreas. Cancer 72: 51-56, 1993. (Pubitemid 23182049)
21. Fujii H, Inagaki M, Kasai S, Miyokawa N, Tokusashi Y, Gabrielson E and Hruban RH: Genetic progression and heterogeneity in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol 151: 1447-1454, 1997. (Pubitemid 27479775)
22. Scarpa A and Zamboni G: Genomic anomalies in pancreatic tumors other than common adenocarcinoma. Ann NY Acad Sci 880: 179-190, 1999. (Pubitemid 29349126)
23. Iacobuzio-Donahue CA, Klimstra DS, Adsay NV, Wilentz RE, Argani P, Sohn TA, Yeo CJ, Cameron JL, Kern SE and Hruban RH: Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. Am J Pathol 157: 755-761, 2000. (Pubitemid 32109368)
24. Moore PS, Orlandini S, Zamboni G, Capelli P, Rigaud G, Falconi M, Bassi C, Lemoine NR and Scarpa A: Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine non-ductal or endocrine tumorigenesis. Br J Cancer 84: 253-262, 2001. (Pubitemid 32113454)
25. Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, Sohn TA, Yeo CJ, Kern SE and Hruban RH: Immunohistochemistry labeling for Dpc4 mirrors genetic status in pancreatic and peripancreatic adenocarcinomas: a new marker of DPC4 inactivation. Am J Pathol 156: 37-43, 2000. (Pubitemid 30644436)
26. Wilentz RE, Iacobuzio-Donahue CA, Argani P, McCarthy DM, Parsons JL, Yeo CJ, Kern SE and Hruban RH: Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res 60: 2002-2006, 2000. (Pubitemid 30207663)