p53 protein expression and DNA ploidy in cystic tumors of the pancreas

Pancreas

Volumn 13, Issue 3, 1996, Pages 247-252

  Fléjou, Jean François ^a,b   Boulange, Brigitte ^a   Bernades, Pierre ^a   Belghiti, Jacques ^a   Hénin, Dominique ^a  

^a BEAUJON HOSPITAL   (France)

^b INSERM   (France)

Author keywords

Cystic tumor; DNA ploidy; Flow cytometry; p53 protein; Pancreas

Indexed keywords

DNA; PROTEIN P53; TUMOR MARKER;

ADULT; ARTICLE; CYSTADENOCARCINOMA; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PANCREAS TUMOR; PLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0029793889     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199610000-00006     Document Type: Article

References (39)

1. Yamaguchi K, Enjoji M. Cystic neoplasms of the pancreas. Gastroenterology 1987;92:1934-43.
2. Warshaw AL, Compton CC, Lewandrowski K, Cardenosa G, Mueller PR. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 1990;212:432-45.
3. Hammel P, Levy P, Voitot H, et al. Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. Gastroenterology 1995;108:1230-5.
4. Bogomoletz WV. Cystic tumours of the exocrine pancreas. In: Anthony PP, MacSween RNM, eds. Recent advances in histopathology. Edinburgh: Churchill-Livingstone, 1992: 141-55.
5. Compagno J, Oertel JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas). A clinicopathologic study of 34 cases. Am J Clin Pathol 1978;69:289-98.
6. Pyke CM, Van Heerden JA, Colby TV, Sarr MG, Weaver AL. The spectrum of serous cystadenoma of the pancreas: clinical, pathologic, and surgical aspects. Ann Surg 1992; 215:132-9.
7. George DH, Murphy F, Michalski R, Ulmer BG. Serous cystadenocarcinoma of the pancreas: a new entity? Am J Surg Pathol 1989;13:61-6.
8. Yoshimi N, Sugie S, Tanaka T, et al. A rare case of serous cystadenocarcinoma of the pancreas. Cancer 1992;69:2449-53.
9. Compagno J, Oertel JE. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 1978;69:573-80.
10. Sessa F, Solcia E, Capella C, et al. Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Arch 1994;425:357-67.
11. Nagai E, Ueki T, Chijiiwa K, Tanaka M, Tsuneyoshi M. Intraductal papillary mucinous neoplasms of the pancreas associated with so-called "mucinous ductal ectasia." Histochemical and immunohistochemical analysis of 29 cases. Am J Surg Pathol 1995;19:576-89.
12. Mendelsohn G. Papillary cystic tumor of the pancreas. An enigma. Am J Clin Pathol 1992;98:476-7.
13. Porschen R, Remy U, Bevers G, Schauseil S, Hengels KJ, Borchard F. Prognostic significance of DNA ploidy in adenocarcinoma of the pancreas. A flow cytometric study of paraffin-embedded specimens. Cancer 1993;71:3846-50.
14. Böttger TC, Störkel S, Wellek S, Stölke M, Junginger T. Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study. Cancer 1994;73:63-73.
15. Barton CM, Staddon SL, Hughes CM, et al. Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. Br J Cancer 1991;64:1076-82.
16. Boschmann CR, Stryker S, Reddy JK, Sambasiva Rao M. Expression of p53 protein in precursor lesions and adenocarcinoma of human pancreas. Am J Pathol 1994;145: 1291-5.
17. Cubilla AL, Fitzgerald PJ. Tumors of the exocrine pancreas. In: Atlas of tumor pathology, 2nd series. Fascicle 19. Armed Forces Institute of Pathology, 1984.
18. Lewandrowski K, Warshaw A, Compton C. Macrocystic serous cystadenoma of the pancreas: a morphologic variant differing from microcystic adenoma. Hum Pathol 1992;23: 871-5.
19. Egawa N, Maillet B, Schröder S, Mukai K, Klöppel G. Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma. Virchows Arch 1994;424:13-7.
20. Shi SR, Key ME, Kalra KL. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991;39: 741-8.
21. Baas IO, Mulder JWR, Offerhaus GJA, Vogelstein B, Hamilton SR. An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms. J Pathol 1994;172:5-12.
22. Hamelin R, Fléjou J-F, Muzeau F, et al. TP53 gene mutations and p53 protein immunoreactivity in malignant and premalignant Barrett's esophagus. Gastroenterology 1994; 107:1012-8.
23. Tenaud C, Negoescu A, Labat-Moleur F, Legros Y, Soussi T, Brambilla E. p53 immunolabeling in archival paraffin-embedded tissues: optimal protocol based on microwave heating for eight antibodies on lung carcinomas. Mod Pathol 1994;7:853-9.
24. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 1983;31:1333-5.
25. Mathieu D, Guigui B, Valette PJ, et al. Pancreatic cystic neoplasms. Radiol Clin North Am 1989;27:163-76.
26. Hodgkinson DJ, Remine WH, Weiland LH. Pancreatic cystadenoma. A clinicopathologic study of 45 cases. Arch Surg 1978;113:512-9.
27. Hodgkinson DJ, Remine WH, Weiland LH. A clinicopathologic study of 21 cases of pancreatic cystadenocarcinoma. Ann Surg 1978;188:679-84.
28. Lévy M, Lévy P, Hammel P, et al. Diagnostic des cystadénomes et cystadénocarcinomes du pancréas. Gastroenterol Clin Biol 1995;19:189-96.
29. Unger PD, Danque POV, Fuchs A, Kaneko M. DNA flow cytometric evaluation of serous and mucinous cystic neoplasms of the pancreas. Arch Pathol Lab Med 1991;115: 563-5.
30. Pellagata NS, Sessa F, Renault B, et al. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res 1994; 54:1556-60.
31. Harris CC, Hollstein M. Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 1993;329:1318-27.
32. Lemoine NR, Jain S, Hughes CM, et al. Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 1992;102:230-6.
33. Korc M, Chandrasekar B, Yamanaka Y, Friess H, Büchler M, Beger HG. Overexpression of the epidermal-growth-factor receptor in human pancreas cancer is associated with concomitant increase in the levels of epidermal growth factor and transforming growth factor alpha. J Clin Invest 1992; 90:1352-60.
34. Redston MS, Caldas C, Seymour AB, et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 1994;54:3025-33.
35. Kirby RE, Lewandrowski KB, Southern JF, Compton CC, Warshaw AL. Relation of epidermal growth factor receptor and estrogen receptor-independent pS2 protein to the malignant transformation of mucinous cystic neoplasms of the pancreas. Arch Surg 1995;130:69-72.
36. Yanagisawa A, Kato Y, Ohtake K, et al. c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas. Jpn J Cancer Res 1991;82:1057-60.
37. Hoshi T, Imai M, Ogawa K. Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas. J Surg Oncol 1994;55:84-91.
38. Pettinato G, Manivel JC, Ravetto C, Terraciano LM, Gould EW, Di Tuoro A. Papillary cystic tumor of the pancreas. A clinicopathologic study of 20 cases with cytologic, immunohistochemical, ultrastructural, and flow cytometric observations, and a review of the literature. Am J Clin Pathol 1992; 98:478-88.
39. Petrella T, Rat P, Lizard G, Dusserre-Guion L, Poulard G, Michiels R. Tumeur papillaire et kystique du pancréas. Etude histologique, immunohistochimique et par cytométrie en flux. Gastroenterol Clin Biol 1994;18:1021-7.