p16 and p53 gene alterations and accumulations in the malignant evolution of intraductal papillary-mucinous tumors of the pancreas

Journal of Hepato-Biliary-Pancreatic Surgery

Volumn 9, Issue 1, 2002, Pages 76-85

  Wada, Keita ^a  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Intraductal papillary mucinous tumors of the pancreas; K ras; Loss of heterozygosity; p16; p53

Indexed keywords

PROTEIN P16; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER GENETICS; CANCER GRADING; CARCINOGENESIS; CHROMOSOME MICRODISSECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; INVASIVE CARCINOMA; MALE; MUCINOUS CARCINOMA; MUTATION RATE; ONCOGENE K RAS; PANCREAS ADENOMA; PANCREAS CARCINOMA; PAPILLARY CARCINOMA; PROGNOSIS;

ADENOCARCINOMA, MUCINOUS; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, PANCREATIC DUCTAL; CARCINOMA, PAPILLARY; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENES, P16; GENES, P53; GENES, RAS; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MUTATION; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; SURVIVAL ANALYSIS;

EID: 0036243735     PISSN: 09441166     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005340200007     Document Type: Article

References (56)

1. Four cases of "mucin-producing" cancer of the pancreas on specific findings of papilla of Vater
2. An introduction to mucin-producing tumors of the pancreas: Why they deserve more attention?
3. Intraductal papillary neoplasm of the pancreas. A clinicopathologic study of six patients
4. Intraductal mucin-hypersecreting neoplasms of the pancreas
5. Mucin-hypersecreting tumor of the pancreas with mucin extrusion through an enlarged papilla
6. Intraductal mucin-producing tumors of the pancreas
7. Differences between solid and duct-ectatic types of pancreatic ductal carcinomas
8. Histological typing of tumours of the exocrine pancreas
9. Duct-ectatic type of tumor of the pancreas. New concept of pancreatic neoplasm
10. Intraductal papillary mucinous tumors of the pancreas. Imaging studies and treatment strategies
11. Clinicopathologic view of intraductal papillary-mucinous tumor of the pancreas
12. Intraductal neoplasm of the pancreas
13. Pattern of the recurrence after resection for intraductal papillary mucinous tumors of the pancreas
14. Outcome after surgical resection of intraductal papillary and mucinous tumurs of the pancreas
15. Clinicopathological features and treatment of intraductal papillary mucinous tumor of the pancreas
16. Problems in histological diagnosis of intraductal papillary-mucinous tumor (IPMT)
17. Intraductal papillary mucinous tumors of the pancreas: Pancreatic resection guided by preoperative morphological assessment and intraoperative frozen section examination
18. Molecular genetics of exocrine pancreatic neoplasms
19. Tumor-suppressive pathways in pancreatic carcinoma
20. c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas
21. Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five cases
22. Ki-ras oncogene activation in preinvasive pancreatic cancer
23. The point mutation of c-Ki-ras at codon 12 in carcinoma of the pancreatic head region and in intraductal mucin-hypersecreting neoplasm of the pancreas
24. Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: An investigation of tumours cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients
25. Frequent K-ras mutations and absence of p53 mutations in mucin producing tumors of the pancreas
26. K-ras mutation and p53 protein accumulation in intraductal mucin hypersecreting neoplasms of the pancreas
27. Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas
28. Genetic progression and heterogeneity in intraductal papillary-mucinous neoplasms of the pancreas
29. Immunohistochemical analysis of expression of molecular biologic factors in intraductal papillary-mucinous tumors of pancreas. Diagnostic and biologic significance
30. K-ras gene mutations and loss of heterozygosity at the p53 locus relative to histological characteristics of mucin-producing tumors of the pancreas
31. p53 Protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy
32. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
33. K-ras codon 12 mutations occur very frequently in pancreatic adenocarcinomas
34. Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing
35. Ki-ras oncogene activation in preinvasive pancreatic cancer
36. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
37. K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions
38. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
39. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
40. Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors
41. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
42. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression
43. Pancreatic adenocarcinomas frequently show p53 gene mutations
44. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
45. Overexpression of p53 protein in adenocarcinoma of the pancreas
46. p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma
47. Frequent c-Ki-ras oncogene activation in mucus cell hyperplasia of pancreas suffering from chronic inflammation
48. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
49. Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia
50. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
51. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
52. A genetic model for colorectal tumorgenesis
53. Microallelotyping defines the sequence and tempo of allelic losses at tumor suppressor gene loci during colorectal cancer progression
54. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia
55. Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas