Induction of competence regulons as a general response to stress in gram-positive bacteria

Annual Review of Microbiology

Volumn 60, Issue , 2006, Pages 451-475

  Claverys, Jean Pierre ^a   Prudhomme, Marc ^a   Martin, Bernard ^a  

^a UMR   (France)

Author keywords

Diversity; Fratricide; Pheromone; SOS; Transformation

Indexed keywords

DNA; SOS PROTEIN;

BACILLUS SUBTILIS; BACTERIUM TRANSFORMATION; COMPETENCE; DNA DAMAGE; DNA REPAIR; GENE INDUCTION; GENETIC TRANSFORMATION; GENETIC VARIABILITY; GRAM POSITIVE BACTERIUM; MICROBIAL DIVERSITY; NONHUMAN; PRIORITY JOURNAL; QUORUM SENSING; REGULATORY MECHANISM; REGULON; REVIEW; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; STRESS;

BACILLUS SUBTILIS; CELL COUNT; GENOME, BACTERIAL; GRAM-POSITIVE BACTERIA; MITOMYCIN; REGULON; SOS RESPONSE (GENETICS); STREPTOCOCCUS PNEUMONIAE; TRANSFORMATION, BACTERIAL; VARIATION (GENETICS);

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 33746320813     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.micro.60.080805.142139     Document Type: Review

References (142)

1. Albano M, Smits WK, Ho LT, Kraigher B, Mandic-Mulec I, et al. 2005. The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions. J. Bacteriol. 187:2010-19
2. Alloing G, Martin B, Granadel C, Claverys JP. 1998. Development of competence in Streptococcus pneumoniae: pheromone auto-induction and control of quorum-sensing by the oligopeptide permease. Mol. Microbiol. 29:75-84
3. Ansaldi M, Marolt D, Stebe T, Mandic-Mulec I, Dubnau D. 2002. Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants. Mol. Microbiol. 44:1561-73
4. Au N, Kuester-Schoeck E, Mandava V, Bothwell LE, Canny SP, et al. 2005. Genetic composition of the Bacillus subtilis SOS system. J. Bacteriol. 187:7655-66
5. Bacon Schneider K, Palmer TM, Grossman AD. 2002. Characterization of comQ and comX, two genes required for production of ComX pheromone in Bacillus subtilis. J. Bacteriol. 184:410-19
6. Beaber JW, Hochhut B, Waldor MK. 2004. SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature 427:72-74
7. Bergé M, Mortier-Barrière I, Martin B, Claverys JP. 2003. Transformation of Streptococcus pneumoniae relies on DprA- and RecA-dependent protection of incoming single strands. Mol. Microbiol. 50:527-36
8. Berge M, Moscoso M, Prudhomme M, Martin B, Claverys JP. 2002. Uptake of transforming DNA in Gram-positive bacteria: a view from Streptococcus pneumoniae. Mol. Microbiol. 45:411-21
9. Berka RM, Hahn J, Albano M, Draskovic I, Persuh M, et al. 2002. Microarray analysis of the Bacillus subtilis K-state: genome-wide expression changes dependent on ComK. Mol. Microbiol. 43:1331-45
10. Bernstein H, Byerly HC, Hopf FA, Michod RE. 1985. The evolutionary role of recombinational repair and sex. Int. Rev. Cytol. 96:1-24
11. Bongiorni C, Ishikawa S, Stephenson S, Ogasawara N, Perego M. 2005. Synergistic regulation of competence development in Bacillus subtilis by two Rap-Phr systems. J. Bacteriol. 187:4353-61
12. Chen I, Christie PJ, Dubnau D. 2005. The ins and outs of DNA transfer in bacteria. Science 310:1456-60
13. Chen I, Dubnau D. 2004. DNA uptake during bacterial transformation. Nat. Rev. Microbiol. 2:241-49
14. Chen JD, Morrison DA. 1987. Modulation of competence for genetic transformation m Streptococcus pneumoniae. J. Gen. Microbiol. 133:1959-67
15. Claverys JP, Grossiord B, Alloing G. 2000. Is the Ami-AliAB oligopeptide permease of Streptococcus pneumoniae involved in sensing environmental conditions? Res. Microbiol. 151:1-7
16. Claverys JP, Håvarstein LS. 2002. Extra-cellular peptide control of competence for genetic transformation in Streptococcus pneumoniae. Front. Biosci. 7:1798-814
17. Claverys JP, Martin B. 2003. Bacterial "competence" genes: signatures of active transformation, or only remnants? Trends Microbiol. 11:161-65
18. Claverys JP, Prudhomme M, Mortier-Barrière I, Martin B. 2000. Adaptation to the environment: Streptococcus pneumoniae, a paradigm for recombination-mediated genetic plasticity? Mol. Microbiol. 35:251-59
19. Comella N, Grossman AD. 2005. Conservation of genes and processes controlled by the quorum response in bacteria: characterization of genes controlled by the quorum-sensing transcription factor ComA in Bacillus subtilis. Mol. Microbiol. 57:1159-74
20. Core L, Perego M. 2003. TPR-mediated interaction of RapC with ComA inhibits response regulator DNA binding for competence development in Bacillus subtilis. Mol. Microbiol. 49:1509-22
21. Dagkessamanskaia A, Moscoso M, Hénard V, Guiral S, Overweg K, et al. 2004. Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: Competence triggers stationary phase autolysis of ciaR mutant cells. Mol. Microbiol. 51:1071-86
22. de Saizieu A, Certa U, Warrington J, Gray C, Keck W, et al. 1998. Bacterial transcript imaging by hybridization of total RNA to oligonucleotide arrays. Nat. Biotechnol. 16:45-48
23. Derré I, Rapoport G, Msadek T. 1999. CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in gram-positive bacteria. Mol. Microbiol. 31:117-31
24. Drlica K, Zhao X. 1997. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microb. Mol. Biol. Rev. 61:377-92
25. Dubnau D. 1991. Genetic competence in Bacillus subtilis. Microbiol. Rev. 55:395-424
26. Dubnau D. 1999. DNA uptake in bacteria. Annu. Rev. Microbiol. 53:217-44
27. Dubnau D, Lovett CM. 2002. Transformation and recombination. See Ref. 118a, pp. 453-71
28. 27a. Duigou S, Ehrlich SD, Noirot P, Noirot-Gros MF. 2004. Distinctive genetic features exhibited by the Y-family DNA polymerases in Bacillus subtilis. Mol. Microbiol. 54:439-51
29. 27b. Duigou S, Ehrlich SD, Noirot P, Noirot-Gros MF. 2005. DNA polymerase I acts in translesion synthesis mediated by the Y-polymerases in Bacillus subtilis. Mol. Microbiol. 57:678-90
30. 27c. Dunny GM, Winans SC, eds. 1999. Cell-Cell Signaling in Bacteria. Washington, DC: ASM Press
31. Foster PL. 2005. Stress responses and genetic variation in bacteria. Mutat. Res. 569:3-11
32. Gasc AM, Sicard N, Claverys JP, Sicard AM. 1980. Lack of SOS repair in Streptococcus pneumoniae. Mutat. Res. 70:157-65
33. Gilmore MS, Haas W. 2005. The selective advantage of microbial fratricide. Proc. Natl. Acad. Sci. USA 102:8401-2
34. Grossman AD. 1995. Genetic networks controlling the initiation of sporulation and the development of genetic competence in Bacillus subtilis. Annu. Rev. Genet. 29:477-508
35. Grove DE, Willcox S, Griffith JD, Bryant FR. 2005. Differential single-stranded DNA binding properties of the paralogous SsbA and SsbB proteins from Streptococcus pneumoniae. J. Biol. Chem. 280:11067-73
36. Guiral S, Dagkessamanskaia A, Moscoso M, Claverys JP. 2007. Competence in Streptococcus pneumoniae: What is it for? See Ref. 36a, In press
37. Guiral S, Hénard V, Granadel C, Martin B, Claverys JP. 2006. Inhibition of competence development in Streptococcus pneumoniae by increased basal-level expression of the ComDE two-component regulatory system. Microbiology 152:323-31
38. Guiral S, Mitchell TJ, Martin B, Claverys JP. 2005. Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements. Proc. Natl. Acad. Sci. USA 102:8710-15
39. Haijema BJ, Hahn J, Haynes J, Dubnau D. 2001. A ComGA-dependent checkpoint limits growth during the escape from competence. Mol. Microbiol. 40:52-64
40. 36a. Hakenbeck R, Chhatwal GS, eds. 2007. The Molecular Biology of Streptococci. Norwich, UK: Horizon Sci. In press
41. Hamoen LW, Haijema B, Bijlsma JJ, Venema G, Lovett CM. 2001. The Bacillus subtilis competence transcription factor, ComK, overrides LexA-imposed transcriptional inhibition without physically displacing LexA. J. Biol. Chem. 276:42901-7
42. Hamoen LW, Kausche D, Marahiel MA, van Sinderen D, Venema G, et al. 2003. The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK. FEMS Microbiol. Lett. 218:299-304
43. Hamoen LW, Smits WK, De Jong A, Holsappel S, Kuipers OP. 2002. Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach. Nucleic Acids Res. 202:5517-28
44. Hamoen LW, Van Werkhoven AF, Dubnau D, Venema G. 1998. The competence transcription factor of Bacillus subtilis recognizes short A/T-rich sequences arranged in a unique, flexible pattern along the DNA helix. Genes Dev. 12:1539-50
45. Hamoen LW, Van Werkhoven AF, Venema G, Dubnau D. 2000. The pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilis. Proc. Natl. Acad. Sci. USA 97:9246-51
46. Hamoen LW, Venema G, Kuipers OP. 2003. Controlling competence in Bacillus subtilis: shared use of regulators. Microbiology 149:9-17
47. Hard FU, Hayer-Hartl M. 2002. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295:1852-58
48. Håvarstein LS, Coomaraswamy G, Morrison DA. 1995. An unmodified heptade-capeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae. Proc. Natl. Acad. Sci. USA 92:11140-44
49. Håvarstein LS, Diep DB, Nes IF. 1995. A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export. Mol. Microbiol. 16:229-40
50. Håvarstein LS, Gaustad P, Nes IF, Morrison DA. 1996. Identification of the streptococcal competence-pheromone receptor. Mol. Microbiol. 21:865-71
51. Håvarstein LS, Hakenbeck R, Gaustad P. 1997. Natural competence in the genus Streptococcus: evidence that streptococci can change pherotype by interspecies recombinational exchanges. J. Bacteriol. 179:6589-94
52. Håvarstein LS, Martin B, Johnsborg O, Granadel C, Claverys JP. 2006. New insights into pneumococcal fratricide: relationship to clumping and identification of a novel immunity factor. Mol. Microbiol. 59:1297-307
53. Håvarstein LS, Morrison DA. 1999. Quorum sensing and peptide pheromones in streptococcal competence for genetic transformation. See Ref. 27c, pp. 9-26
54. 2 stress-responsive regulator PerR positively regulates srfA expression in Bacillus subtilis. J. Bacteriol. 187:6659-67
55. Hoa TT, Tortosa P, Albano M, Dubnau D. 2002. Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comK. Mol. Microbiol. 43:15-26
56. Hoelzer MA, Michod RE. 1991. DNA repair and the evolution of transformation in Bacillus subtilis. III. Sex with damaged DNA. Genetics 128:215-23
57. Hui FM, Zhou L, Morrison DA. 1995. Competence for genetic transformation in Streptococcus pneumoniae: organization of a regulatory locus with homology to two lactococcin A secretion genes. Gene 153:25-31
58. Jarmer H, Larsen TS, Krogh A, Saxild HH, Brunak S, et al. 2001. Sigma-A recognition sites in the Bacillus subtilis genome. Microbiology 147:2417-24
59. Jiang M, Grau R, Perego M. 2000. Differential processing of propeptide inhibitors of Rap phosphatases in Bacillus subtilis. J. Bacteriol. 182:303-10
60. Kausmally L, Johnsborg O, Lunde M, Knutsen E, Håvarstein LS. 2005. Choline-binding protein D (CbpD) in Streptococcus pneumoniae is essential for competence-induced cell lysis. J. Bacteriol. 187:4338-45
61. 56a. Kogoma T. 1997. Stable DNA replication: interplay between DNA replication, homologous recombination, and transcription. Microbiol. Rev. 61:212-38
62. Kowalczykowski SC. 1991. Biochemistry of genetic recombination: Energetics and mechanism of DNA strand exchange. Annu. Rev. Biophys. Biophys. Chem. 20:539-75
63. Kreuzer KN. 2005. Interplay between DNA replication and recombination in prokaryotes. Annu. Rev. Microbiol. 59:43-67
64. Lange R, Wagner C, de Saizieu A, Flint N, Molnos J, et al. 1999. Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae. Gene 237:223-34
65. Lazazzera BA, Grossman AD. 1998. The ins and outs of peptide signaling. Trends Microbiol. 6:288-94
66. Lazazzera BA, Kurtser IG, McQuade RS, Grossman AD. 1999. An autoregulatory circuit affecting peptide signaling in Bacillus subtilis. J. Bacteriol. 181:5193-200
67. Lazazzera BA, Solomon JM, Grossman AD. 1997. An exported peptide functions intracellularly to contribute to cell density signaling in B. subtilis. Cell 89:917-25
68. Lee MS, Morrison DA. 1999. Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation. J. Bacteriol. 181:5004-16
69. Levin BR. 1988. The evolution of sex in bacteria. In The Evolution of Sex, ed. RE Michod, BR Levin, pp. 194-211. Sunderland, MA: Sinauer
70. Little JW. 1984. Autodigestion of LexA and phage lambda repressors. Proc. Natl. Acad. Sci. USA 81:1375-79
71. Lorenz MG, Wackernagel W. 1994. Bacterial gene transfer by natural genetic transformation in the environment. Microbiol. Rev. 58:563-602
72. Love PE, Lyle MJ, Yasbin RE. 1985. DNA-damage-inducible (din) loci are transcriptionally activated in competent Bacillus subtilis. Proc. Natl. Acad. Sci. USA 82:6201-5
73. Luo P, Li H, Morrison DA. 2004. Identification of ComW as a new component in the regulation of genetic transformation in Streptococcus pneumoniae. Mol. Microbiol. 54:172-83
74. Luo P, Morrison DA. 2003. Transient association of an alternative sigma factor, ComX, with RNA polymerase during the period of competence for genetic transformation in Streptococcus pneumoniae. J. Bacteriol. 185:349-58
75. Maamar H, Dubnau D. 2005. Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop. Mol. Microbiol. 56:615-24
76. Magnuson R, Solomon J, Grossman AD. 1994. Biochemical and genetic characterization of a competence pheromone from B. subtilis. Cell 77:207-16
77. Martin B, García P, Castanié MP, Claverys JP. 1995. The recA gene of Streptococcus pneumoniae is part of a competence-induced operon and controls lysogenic induction. Mol. Microbiol. 15:367-79
78. Martin B, Prudhomme M, Alloing G, Granadel C, Claverys JP. 2000. Cross-regulation of competence pheromone production and export in the early control of transformation in Streptococcus pneumoniae. Mol. Microbiol. 38:867-78
79. Mascher T, Zahner D, Merai M, Balmelle N, de Saizieu AB, et al. 2003. The Streptococcus pneumoniae cia regulon: CiaR target sites and transcription profile analysis. J. Bacteriol. 185:60-70
80. Matic I, Taddei F, Radman M. 1996. Genetic barriers among bacteria. Trends Microbiol. 4:69-73
81. Maynard Smith J, Dowson CG, Spratt BG. 1991. Localized sex in bacteria. Nature 349:29-31
82. McQuade RS, Comella N, Grossman AD. 2001. Control of a family of phosphatase regulatory genes (phr) by the alternate sigma factor sigma-H of Bacillus subtilis. J. Bacteriol. 183:4905-9
83. Miller C, Thomsen LE, Gaggero C, Mosseri R, Ingmer H, et al. 2004. SOS response induction by beta-lactams and bacterial defense against antibiotic lethality. Science 305:1629-31
84. Morrison DA. 1997. Streptococcal competence for genetic transformation: regulation by peptide pheromones. Microb. Drug Res. 3:27-37
85. Morrison DA, Baker M. 1979. Competence for genetic transformation in pneumococcus depends on synthesis of a small set of proteins. Nature 282:215-17
86. 80a. Morder-Barrière I, de Saizieu A, Claverys JP, Martin B. 1998. Competence-specific induction of recA is required for full recombination proficiency during transformation in Streptococcus pneumoniae. Mol. Microbiol. 27:159-70
87. Moscoso M, Claverys JP. 2004. Release of DNA into the medium by competent Streptococcus pneumoniae: kinetics, mechanism and stability of the liberated DNA. Mol. Microbiol. 54:783-94
88. Mueller JP, Bukusoglu G, Sonenshein AL. 1992. Transcriptional regulation of Bacillus subtilis glucose starvation-inducible genes: control of gsiA by the ComP-ComA signal transduction system. J. Bacteriol. 174:4361-73
89. Munoz-Najar U, Vijayakumar MN. 1999. An operon that confers UV resistance by evoking the SOS mutagenic response in streptococcal conjugative transposon Tn5252. J. Bacteriol. 181:2782-88
90. Naberhaus F. 1999. Negative regulation of bacterial heat shock genes. Mol. Microbiol. 31:1-8
91. Nakano MM, Magnuson R, Myers A, Curry J, Grossman AD, et al. 1991. srfA is an operon required for surfactin production, competence development, and efficient sporulation in Bacillus subtilis. J. Bacteriol. 173:1770-78
92. Nikolskaya AN, Galperin MY. 2002. A novel type of conserved DNA-binding domain in the transcriptional regulators of the AlgR/AgrA/LytR family. Nucleic Acids Res. 30:2453-59
93. Ogura M, Shimane K, Asai K, Ogasawara N, Tanaka T. 2003. Binding of response regulator DegU to the aprE promoter is inhibited by RapG, which is counteracted by extracellular PhrG in Bacillus subtilis. Mol. Microbiol. 49:1685-97
94. Ogura M, Yamaguchi H, Kobayashi K, Ogasawara N, Fujita Y, et al. 2002. Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK. J. Bacteriol. 184:2344-51
95. Fallen MJ, Wren BW. 1997. The HtrA family of serine proteases. Mol. Microbiol 26:209-21
96. Pao GM, Tam R, Lipschitz LS, Saier MHJ. 1994. Response regulators: structure, function and evolution. Res. Microbiol. 145:356-62
97. Perego M. 1997. A peptide export-import control circuit modulating bacterial development regulates protein phosphatases of the phosphorelay. Proc. Natl. Acad. Sci. USA 94:8612-17
98. Perego M. 1999. Self-signaling by Phr peptides modulates Bacillus subtilis development. See Ref. 27c, pp. 243-58
99. Perego M, Brannigan JA. 2001. Pentapeptide regulation of aspartyl-phosphate phosphatases. Peptides 22:1541-47
100. Perego M, Hanstein C, Welsh KM, Djavakhishvili T, Glaser P, et al. 1994. Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in Bacillus subtilis. Cell 79:1047-55
101. Pestova EV, Håvarstein LS, Morrison DA 1996. Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system. Mol. Microbiol. 21:853-64
102. Peterson S, Cline RT, Tettelin H, Sharov V, Morrison DA. 2000. Gene expression analysis of the Streptococcus pneumoniae competence regulons by use of DNA microarrays. J. Bacteriol. 182:6192-202
103. Peterson S, Sung CK, Cline R, Desai BV, Snesrud E, et al. 2004. Identification of competence pheromone responsive genes in Streptococcus pneumoniae. Mol. Microbiol. 51:1051-70
104. Phillips I, Culebras E, Moreno F, Baquero F. 1987. Induction of the SOS response by new 4-quinolones. J. Antimicrob. Chemother. 20:631-38
105. Pozzi G, Masala L, Iannelli F, Manganelli R, Håvarstein LS, et al. 1996. Competence for genetic transformation in Streptococcus pneumoniae: two allelic variants of the peptide pheromone. J. Bacteriol. 178:6087-90
106. Prudhomme M, Attaiech L, Sanchez G, Martin B, Claverys JP. 2006. Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae. Science 313:89-92
107. 100a. Prudhomme M, Claverys JP. 2007. There will be a light: the use of fee transcriptional fusions in living pneumococcal cells. See Ref. 36a, In press
108. Rallu F, Gruss A, Ehrlich SD, Maguin E. 2000. Acid- and multistress-resistant mutants of Lactococcus lactis: identification of intracellular stress signals. Mol. Microbiol. 35:517-28
109. Ramirez M, Morrison DA, Tomasz A. 1997. Ubiquitous distribution of the competence related genes comA and comC among isolates of Streptococcus pneumoniae. Microb. Drug Res. 3:39-52
110. Ratnayake-Lecamwasam M, Serror P, Wong KW, Sonenshein AL. 2001. Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels. Genes Dev. 15:1093-103
111. Redfield RJ. 1988. Evolution of bacterial transformation: Is sex with dead cells ever better than no sex at all? Genetics 119:213-21
112. Redfield RJ. 1993. Evolution of natural transformation: Testing the DNA repair hypothesis in Bacillus subtilis and Haemophilus influenzae. Genetics 133:755-61
113. Redfield RJ. 1993. Genes for breakfast: the have-your-cake-and-eat-it-too of bacterial transformation. J. Hered. 84:400-4
114. Redfield RJ. 2001. Do bacteria have sex? Nat. Rev. Genet. 2:634-39
115. Redfield RJ, Cameron AD, Qian Q, Hinds J, Ali TR, et al. 2005. A novel CRP-dependent regulon controls expression of competence genes in Haemophilus influenzae. J. Mol. Biol. 347:735-47
116. Redfield RJ, Schrag MR, Dean AM. 1997. The evolution of bacterial transformation: sex with poor relations. Genetics 146:27-38
117. Rimini R, Jansson B, Feger G, Roberts TC, de Francesco M, et al. 2000. Global analysis of transcription kinetics during competence development in Streptococcus pneumoniae. Mol. Microbiol. 36:1279-92
118. Roggiani M, Dubnau D. 1993. ComA, a phosphorylated response regulator protein of Bacillus subtilis, binds to the promoter region of srfA. J. Bacteriol. 175:3182-87
119. Schirmer EC, Glover JR, Singer MA, Lindquist S. 1996. HSP100/Clp proteins: a common mechanism explains diverse functions. Trends Biochem. Sci. 21:289-96
120. Schumann W, Hecker M, Msadek T. 2002. Regulation and function of heat-inducible genes in Bacillus subtilis. See Ref. 118a, pp. 359-68
121. Sebert ME, Palmer LM, Rosenberg M, Weiser JN. 2002. Microarray-based identification of htrA, a Streptococcus pneumoniae gene that is regulated by the CiaRH two-component system and contributes to nasopharyngeal colonization. Infect. Immun. 70:4059-67
122. Serror P, Sonenshein AL. 1996. CodY is required for nutritional repression of Bacillus subtilis genetic competence. J. Bacteriol. 178:5910-15
123. Seto H, Tomasz A. 1975. Protoplast formation and leakage of intramembrane cell components: induction by the competence activator substance of pneumococci. J. Bacteriol. 121:344-53
124. Smits WK, Eschevins CC, Susanna KA, Bron S, Kuipers OP, et al. 2005. Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development. Mol. Microbiol. 56:604-14
125. Solomon JM, Lazazzera BA, Grossman AD. 1996. Purification and characterization of an extracellular peptide factor that affects two different developmental pathways in Bacillus subtilis. Genes Dev. 10:2014-24
126. 118a. Sonenshein AL, Hoch JA, Losick R, eds. 2002. Bacillus subtilis and Its Closest Relatives: From Genes to Cells. Washington, DC: ASM Press
127. Steinmoen H, Knutsen E, Håvarstein LS. 2002. Induction of natural competence in Streptococcus pneumoniae triggers lysis and DNA release from a subfraction of the cell population. Proc. Natl. Acad. Sci. USA 99:7681-86
128. Steinmoen H, Teigen A, Håvarstein LS. 2003. Competence-induced cells of Streptococcus pneumoniae lyse competence-deficient cells of the same strain during cocultivation. J. Bacteriol. 185:7176-83
129. Stephenson S, Mueller C, Jiang M, Perego M. 2003. Molecular analysis of Phr peptide processing in Bacillus subtilis. J. Bacteriol. 185:4861-71
130. Stock AM, Robinson VL, Goudreau PN. 2000. Two-component signal transduction. Annu. Rev. Biochem. 69:183-215
131. Sung CK, Morrison DA. 2005. Two distinct functions of ComW in stabilization and activation of the alternative sigma factor ComX in Streptococcus pneumoniae. J. Bacteriol. 187:3052-61
132. Sung HM, Yeamans G, Ross CA, Yasbin RE. 2003. Roles of YqjH and YqjW, homologs of the Escherichia coli UmuC/DinB or Y superfamily of DNA polymerases, in stationary-phase mutagenesis and UV-induced mutagenesis of Bacillus subtilis. J. Bacteriol. 185:2153-60
133. Tomasz A. 1965. Control of the competent state in Pneumococcus by a hormone-like cell product: an example for a new type of regulatory mechanism in bacteria. Nature 208:155-59
134. Tomasz A. 1966. Model for the mechanism controlling the expression of competence state in pneumococcus cultures. J. Bacteriol. 91:1050-61
135. Tomasz A, Hotchkiss RD. 1964. Regulation of the transformability of pneumococcal cultures by macromolecular cell products. Proc. Natl. Acad. Sci. USA 51:480-87
136. Tortosa P, Dubnau D. 1999. Competence for transformation: a matter of taste. Curr. Opin. Microbiol. 2:588-92
137. Turgay K, Hahn J, Burghoorn J, Dubnau D. 1998. Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor. EMBO J. 17:6730-38
138. Turgay K, Hamoen LW, Venema G, Dubnau D. 1997. Biochemical characterization of a molecular switch involving the heat shock protein ClpC, which controls the activity of ComK, the competence transcription factor of Bacillus subtilis. Genes Dev. 11:119-28
139. Waters CM, Bassler BL. 2005. Quorum sensing: cell-to-cell communication in bacteria. Annu. Rev. Cell. Dev. Biol. 21:319-46
140. Ween O, Gaustad P, Håvarstein LS. 1999. Identification of DNA binding sites for ComE, a key regulator of natural competence in Streptococcus pneumoniae. Mol. Microbiol. 33:817-27
141. Whatmore AM, Barcus VA, Dowson CG. 1999. Genetic diversity of the streptococcal competence (com) gene locus. J. Bacteriol. 181:3144-54
142. Zuber P, Nakano MM, Marahiel MA. 1993. Peptide antibiotics of bacilli and other gram-positive bacteria. In Bacillus subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics, ed. AL Sonenshein, J Hoch, R Losick, pp. 897-916. Washington, DC: ASM Press