Type 2 diabetes and obesity in children and adolescents: Experience from studies in Taiwanese population

Current Diabetes Reviews

Volumn 2, Issue 2, 2006, Pages 185-193

  Chang, Ling Yin ^a,b   Li, Hung Yuan ^a   Wei, Jung Nan ^c   Chuang, Lee Ming ^a,d  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Childhood; Diabetes mellitus; Mass screening; Obesity; Taiwan

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACARBOSE; ADIPONECTIN; ALPHA GLUCOSIDASE INHIBITOR; CALPAIN 10; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 4; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INSULIN; INSULIN DERIVATIVE; INTERLEUKIN 6; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; LEPTIN; MEGLITINIDE; METFORMIN; ORAL ANTIDIABETIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; RESISTIN; SIBUTRAMINE; SULFONYLUREA DERIVATIVE; TETRAHYDROLIPSTATIN; TUMOR NECROSIS FACTOR ALPHA;

BEHAVIOR MODIFICATION; BIRTH WEIGHT; BODY WEIGHT DISORDER; CLINICAL FEATURE; CLINICAL TRIAL; DIABETOGENESIS; DIET RESTRICTION; DIFFERENTIAL DIAGNOSIS; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; EDEMA; ETHNOLOGY; FAMILY HISTORY; GASTROINTESTINAL SYMPTOM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSURIA; HEREDITY; HIGH RISK POPULATION; HUMAN; HYPERTENSION; HYPOGLYCEMIA; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SENSITIVITY; LIFESTYLE; MASS SCREENING; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PREVALENCE; PRIMARY PREVENTION; PRIORITY JOURNAL; PUBERTY; REVIEW; RISK FACTOR; RISK REDUCTION; SEX DIFFERENCE; SOCIAL SUPPORT; SYSTEMATIC REVIEW; TACHYCARDIA; TAIWAN; URINALYSIS; WEIGHT GAIN;

ADOLESCENT; ASIA; BEHAVIOR THERAPY; CHILD; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; OBESITY; POLYCYSTIC OVARY SYNDROME; TAIWAN; UNITED STATES;

EID: 33746120749     PISSN: 15733998     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339906776818578     Document Type: Review

References (112)

1. Hu FB, Stampfer MJ, Haffner SM, Solomon CG, Willett WC, Manson JE. Elevated risk of cardiovascular disease prior to clinical diagnosis of type 2 diabetes. Diabetes Care 2002; 25: 1129-1134.
2. Rosenbloom AL. Increasing incidence of type 2 diabetes in children and adolescents: treatment considerations. Paediatr Drugs 2002; 4: 209-221.
3. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998; 21: 1414-1431.
4. Winer N, Sowers JR. Epidemiology of diabetes. J Clin Pharmacol 2004; 44: 397-405.
5. Ludwig DS, Majzoub JA, Al Zahrani A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, and obesity. Pediatrics 1999; 103: E26.
6. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 2005; 146: 693-700.
7. Dabelea D, Hanson RL, Bennett PH, Roumain J, Knowler WC, Pettitt DJ. Increasing prevalence of Type II diabetes in American Indian children. Diabetologia 1998; 41: 904-910.
8. Pinhas-Hamiel O, Dolan LM, Daniels SR, Standiford D, Khoury PR, Zeitler P. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr 1996; 128: 608-615.
9. Ball GD, McCargar LJ. Childhood obesity in Canada: a review of prevalence estimates and risk factors for cardiovascular diseases and type 2 diabetes. Can J Appl Physiol 2003; 28: 117-140.
10. Braun B, Zimmermann MB, Kretchmer N, Spargo RM, Smith RM, Gracey M. Risk factors for diabetes and cardiovascular disease in young Australian aborigines. A 5-year follow-up study. Diabetes Care 1996; 19: 472-479.
11. Hotu S, Carter B, Watson PD, Cutfield WS, Cundy T. Increasing prevalence of type 2 diabetes in adolescents. J Paediatr Child Health 2004; 40: 201-204.
12. Kitagawa T, Owada M, Urakami T, Yamauchi K. Increased incidence of non-insulin dependent diabetes mellitus among Japanese schoolchildren correlates with an increased intake of animal protein and fat. Clin Pediatr (Phila) 1998; 37: 111-115.
13. Wei JN, Chuang LM, Lin CC, Chiang CC, Lin RS, Sung FC. Childhood diabetes identified in mass urine screening program in Taiwan, 1993-1999. Diabetes Res Clin Pract 2003; 59: 201-206.
14. Wei JN, Sung FC, Lin CC, Lin RS, Chiang CC, Chuang LM. National surveillance for type 2 diabetes mellitus in Taiwanese children. JAMA 2003; 290: 1345-1350.
15. World Health Organization. (2004). Fight childhood obesity to prevent diabetes, say WHO and IDF.). http://www.who.tnt//med: acento/news/release/2004/pr8/cn
16. Strauss RS, Pollack HA. Epidemic increase in childhood overweight, 1986-1998. JAMA 2001; 286: 2845-2848.
17. Livingstone B. Epidemiology of childhood obesity in Europe. Eur J Pediatr 2000; 159 Suppl 1: S14-S34.
18. Luo J, Hu FB. Time trands of obesity in pre-school children in China from 1989 to 1997. Int J Obes Relat Metab Disord 2002; 26: 553-558.
19. Flodmark CE, Lissau I, Moreno LA, Pietrobelli A, Widhalm K. New insights into the field of children and adolescents' obesity: the European perspective. Int J Obes Relat Metab Disord 2004; 28: 1189-1196.
20. Lissau I, Overpeck MD, Ruan WJ, Due P, Holstein BE, Hediger ML. Body Mass Index and Overweight in Adolescents in 13 European Countries, Israel, and the United States. Arch Pediatr Adolesc Med 2004; 158: 27-33.
21. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. Br Med J 2000; 320: 1240-1243.
22. Dietz WH, Bellizzi MC. Introduction: the use of body mass index to assess obesity in children. Am J Clin Nutr 1999; 70: 123S-125S.
23. Chu NF. Prevalence and trends of obesity among school children in Taiwan - the Taipei Children Heart Study. Int J Obes Relat Metab Disord 2001; 25: 170-176.
24. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26 (Suppl 1): S5-20.
25. Keenan H, Lipton R, Zierold K, Patel A, Stolte K, Chambers E. What proportion of diabetes in minority young people is actually type 2? Am J Epidemiol 1990; 149: s2.
26. Lindgren CM, Hirschhorn JN. The genetics of type 2 diabetes. Endocrinologist 2001; 11: 178-187.
27. Stern MP. The search for type 2 diabetes susceptibility genes using whole-genome scans: an epidemiologist's perspective. Diabetes Metab Res Rev 2002; 18: 106-113.
28. Horikawa Y, Oda N, Cox NJ, et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 2000; 26: 163-175.
29. Rotimi CN, Chen G, Adeyemo AA, et al. A genome-wide search for type 2 diabetes susceptibility genes in west africans: The Africa America Diabetes Mellitus (AADM) Study. Diabetes 2004; 53: 838-841.
30. Mori Y, Otabe S, Dina C, et al. Genome-wide search for type 2 diabetes in japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p. Diabetes 2002; 51: 1247-1255.
31. Xiang K, Wang Y, Zheng T, et al. Genome-wide search for type 2 diabetes/ impaired glucose homeostasis susceptibility genes in the chinese: Significant Linkage to Chromosome 6q21-q23 and Chromosome 1q21-q24. Diabetes 2004; 53: 228-234.
32. Chiu YF, Chuang LM, Hsiao CF, et al. An autosomal genome-wide scan for loci linked to pre-diabetic phenotypes in nondiabetic Chinese subjects from the Stanford Asia-Pacific Program of Hypertension and Insulin Resistance Family Study. Diabetes 2005; 54: 1200-1206.
33. Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000; 26: 76-80.
34. Gloyn AL, Weedon MN, Owen KR, et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003; 52: 568-572.
35. Yang WS, Hsiung CA, Ho LT, et al. Genetic epistasis of adiponectin and PPARgamma2 genotypes in modulation of insulin sensitivity: a family-based association study. Diabetologia 2003; 46: 977-983.
36. Curhan GC, Willett WC, Rimm EB, Spiegelman D, Ascherio AL, Stampfer MJ. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 1996; 94: 3246-3250.
37. Phipps K, Barker DJ, Hales CN, Fall CH, Osmond C, Clark PM. Fetal growth and impaired glucose tolerance in men and women. Diabetologia 1993; 36: 225-228.
38. Dabelea D, Pettitt DJ, Hanson RL, Imperatore G, Bennett PH, Knowler WC. Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults. Diabetes Care 1999; 22: 944-950.
39. Bavdekar A, Yajnik CS, Fall CH, et al. Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both? Diabetes 1999; 48: 2422-2429.
40. Li C, Johnson MS, Goran MI. Effects of low birth weight on insulin resistance syndrome in caucasian and African-American children. Diabetes Care 2001; 24: 2035-2042.
41. Wei JN, Sung FC, Li CY, et al. Low birth weight and high birth weight infants are both at an increased risk to have type 2 diabetes among schoolchildren in Taiwan. Diabetes Care 2003; 26: 343-348.
42. Dunger DB, Ong KK, Huxtable SJ, et al. Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Nat Genet 1998; 19: 98-100.
43. Hattersley AT, Beards F, Ballantyne E, Appleton M, Harvey R, Ellard S. Mutations in the glucokinase gene of the fetus result in reduced birth weight, Nat Genet 1998; 19: 268-270.
44. Jaquet D, Vidal H, Hankard R, Czernichow P, Levy-Marchal C. Impaired regulation of glucose transporter 4 gene expression in insulin resistance associated with in utero undernutrition. J Clin Endocrinol Metab 2001; 86: 3266-3271.
45. Poulsen P, Vaag AA, Kyvik KO, Moller JD, Beck-Nielsen H. Low birth weight is associated with NIDDM in discordant manozygotic and dizygotic twin pairs. Diabetologia 1997; 40: 439-446.
46. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia, 1992; 35: 595-601.
47. Leslie RD, Volkmann HP, Poncher M, Hanning I, Orskov H, Alberti KG. Metabolic abnormalities in children of non-insulin dependent diabetics. Br Med J (Clin Res Ed) 1986; 293: 840-842.
48. Ishikawa M, Pruneda ML, Adams-Huet B, Raskin P. Obesity-independent hyperinsulinemia in nondiabetic first-degree relatives of individuals with type 2 diabetes. Diabetes 1998; 47: 788-792.
49. van Haeften TW, Dubbeldam S, Zonderland ML, Erkelens DW. Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects. Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests. Diabetes Care 1998; 21: 278-282.
50. Fernandez-Castaner M, Biarnes J, Camps I, Ripolles J, Gomez N, Soler J. Beta-cell dysfunction in first-degree relatives of patients with non-insulin-dependent diabetes mellitus. Diabet Med 1996; 13: 953-959.
51. Pimenta W, Korytkowski M, Mitrakou A, et al. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA 1995; 273: 1855-1861.
52. Silverman BL, Metzger BE, Cho NH, Loeb CA. Impaired glucose tolerance in adolescent offspring of diabetic mothers. Relationship to fetal hyperinsulinism. Diabetes Care 1995; 18: 611-617.
53. Arslanian SA, Bacha F, Saad R, Gungor N. Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth. Diabetes Care 2005; 28: 115-119.
54. Rosenbaum M, Nonas C, Horlick M, et al. Beta-cell function and insulin sensitivity in early adolescence: association with body fatness and family history of type 2 diabetes mellitus. J Clin Endocrinol Metab 2004; 89: 5469-5476.
55. De Pergola G, Pannacciulli N, Minenna A, Martina RA, Cannito F, Giorgino R. Fuel metabolism in adult individuals with a wide range of body mass index: effect of a family history of type 2 diabetes. Diabetes Nutr Metab 2003; 16: 41-47.
56. Dabelea D, Hanson RL, Lindsay RS, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 2000; 49: 2208-2211.
57. Molyneaux L, Constantino M, Yue D. Strong family history predicts a younger age of onset for subjects diagnosed with type 2 diabetes. Diabetes Obes Metab 2004; 6: 187-194.
58. NEEL JV. Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 1962; 14: 353-362.
59. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89: 2548-2556.
60. Rajala MW, Scherer PE. Minireview: The adipocyte - at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003; 144: 3765-3773.
61. Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307: 426-430.
62. Tsou PL, Jiang YD, Chang CC, et al. Sex-related differences between adiponectin and insulin resistance in schoolchildren. Diabetes Care 2004; 27: 308-313.
63. Sinha R, Fisch G, Teague B, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002; 346: 802-810.
64. Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 1999; 103: 1175-1182.
65. Berenson GS, Srinivasan SR, Bao W, Newman WP, III, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998; 338: 1650-1656.
66. Carey DG, Jenkins AB, Campbell LV, Freund J, Chisholm DJ. Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 1996; 45: 633-638.
67. O'Shaughnessy IM, Myers TJ, Stepniakowski K, et al. Glucose metabolism in abdominally obese hypertensive and normotensive subjects. Hypertension 1995; 26: 186-192.
68. Gabriely I, Ma XH, Yang XM, et al. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 2002; 51: 2951-2958.
69. Palmert MR, Gordon CM, Kartashov AI, Legro RS, Emans SJ, Dunaif A. Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome. J Clin Endocrinol Metab 2002; 87: 1017-1023.
70. Solomon CG, Hu FB, Dunaif A, et al. Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus. JAMA 2001; 286: 2421-2426.
71. Weerakiet S, Srisombut C, Bunnag P, Sangtong S, Chuangsoongnoen N, Rojanasakul A. Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in Asian women with polycystic ovary syndrome. Int J Gynaecol Obstet 2001; 75: 177-184.
72. Lewy VD, Danadian K, Witchel SF, Arslanian S. Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome. J Pediatr 2001; 138: 38-44.
73. Dunaif A, Finegood DT. Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab 1996; 81: 942-947.
74. Freedman DS, Srinivasan SR, Burke GL, et al. Relation of body fat distribution to hyperinsulinemia in children and adolescents: the Bogalusa Heart Study. Am J Clin Nutr 1987; 46: 403-410.
75. Burke GL, Webber LS, Srinivasan SR, Radhakrishnamurthy B, Freedman DS, Berenson GS. Fasting plasma glucose and insulin levels and their relationship to cardiovascular risk factors in children: Bogalusa Heart Study. Metabolism 1986; 35: 441-446.
76. Arslanian S, Suprasongsin C, Janosky JE. Insulin secretion and sensitivity in black versus white prepubertal healthy children. J Clin Endocrinol Metab 1997; 82: 1923-1927.
77. Gower BA, Granger WM, Franklin F, Shewchuk RM, Goran MI. Contribution of insulin secretion and clearance to glucose-induced insulin concentration in african-american and caucasian children. J Clin Endocrinol Metab 2002; 87: 2218-2224.
78. Arslanian S. Insulin secretion and sensitivity in healthy African-American vs American white children. Clin Pediatr (Phila) 1998; 37: 81-88.
79. Goran MI, Bergman RN, Cruz ML, Watanabe R. Insulin resistance and associated compensatory responses in african-american and Hispanic children. Diabetes Care 2002; 25: 2184-2190.
80. Pan WH, Flegal KM, Chang HY, Yeh WT, Yeh CJ, Lee WC. Body mass index and obesity-related metabolic disorders in Taiwanese and US whites and blacks: implications for definitions of overweight and obesity for Asians. Am J Clin Nutr 2004; 79: 31-39.
81. McNeely MJ, Boyko EJ. Type 2 diabetes prevalence in Asian Americans: results of a national health survey. Diabetes Care 2004; 27: 66-69.
82. Fagot-Campagna A, Pettitt DJ, Engelgau MM, et al. Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 2000; 136: 664-672.
83. Moran A, Jacobs DR Jr, Steinberger J, et al. Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 1999; 48: 2039-2044.
84. American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care 2000; 23: 381-389.
85. Goran MI, Gower BA. Longitudinal study on pubertal insulin resistance. Diabetes 2001; 50: 2444-2450.
86. American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care 2005; 28: S4-36.
87. Balagopal P, George D, Yarandi H, Funanage V, Bayne E. Reversal of obesity-related hypoadiponectinemia by lifestyle intervention: a controlled, randomized study in obese adolescents. J Clin Endocrinol Metab 2005; 90: 6192-6197.
88. Colantuoni C, Rada P, McCarthy J, et al. Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. Obes Res 2002; 10: 478-488.
89. Villani S. Impact of media on children and adolescents: a 10-year review of the research. J Am Acad Child Adolesc Psychiatry 2001; 40: 392-401.
90. Baranowski T, Thompson WO, DuRant RH, Baranowski J, Puhl J. Observations of physical activity in physical locations: age, gender, ethnicity, and month effects. Res Q Exerc Sport 1993; 64: 127-133.
91. Godoy-Matos A, Carraro L, Vieira A, et al. Treatment of obese adolescents with sibutramine: a randomized, double-blind, controlled study. J Clin Endocrinol Metab 2005; 90: 1460-1465.
92. Berkowitz RI, Wadden TA, Tershakovec AM, Cronquist JL. Behavior therapy and sibutramine for the treatment of adolescent obesity: a randomized controlled trial. JAMA 2003; 289: 1805-1812.
93. Chanoine JP, Hampl S, Jensen C, Boldrin M, Hauptman J. Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial. JAMA 2005; 293: 2873-2883.
94. Alberti G, Zimmet P, Shaw J, Bloomgarden Z, Kaufman F, Silink M. Type 2 diabetes in the young: the evolving epidemic: the International Diabetes Federation consensus workshop. Diabetes Care 2004; 27: 1798-1811.
95. Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.
96. Hu FB, Manson JE, Stampfer MJ, et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001; 345: 790-797.
97. Epstein LH, Valoski AM, Kalarchian MA, McCurley J. Do children lose and maintain weight easier than adults: a comparison of child and parent weight changes from six months to ten years. Obes Res 1995; 3: 411-417.
98. Faro B, Ingersoll G, Fiore H, Ippolito KS. Improving students' diabetes management through school-based diabetes care. J Pediatr Health Care 2005; 19: 301-308.
99. Jones KL, Arslanian S, Peterokova VA, Park JS, Tomlinson MJ. Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial. Diabetes Care 2002; 25: 89-94.
100. DeFronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med 1995; 333: 541-549.
101. Pearson ER, Starkey BJ, Powell RJ, Gribble FM, Clark PM, Hattersley AT. Genetic cause of hyperglycaemia and response to treatment in diabetes. Lancet 2003; 362: 1275-1281.
102. Miyazaki Y, Mahankali A, Wajcberg E, Bajaj M, Mandarino LJ, DeFronzo RA. Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 2004; 89: 4312-4319.
103. Chiquette E, Ramirez G, Defronzo R. A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors. Arch Intern Med 2004; 164: 2097-2104.
104. Chiasson JL, Josse RG, Hunt JA, et al. The efficacy of acarbose in the treatment of patients with non-insulin-dependent diabetes mellitus. A multicenter controlled clinical trial. Ann Intern Med 1994; 121: 928-935.
105. Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 2003; 290: 486-494.
106. Breuer HW. Review of acarbose therapeutic strategies in the long-term treatment and in the prevention of type 2 diabetes. Int J Clin Pharmacol Ther 2003; 41: 421-440.
107. Delorme S, Chiasson JL. Acarbose in the prevention of cardiovascular disease in subjects with impaired glucose tolerance and type 2 diabetes mellitus. Curr Opin Pharmacol 2005; 5: 184-189.
108. Hanefeld M, Cagatay M, Petrowitsch T, Neuser D, Petzinna D, Rupp M. Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studies. Eur Heart J 2004; 25: 10-16.
109. Zung A, Zadik Z. Acarbose treatment of infant dumping syndrome: extensive study of glucose dynamics and long-term follow-up. J Pediatr Endocrinol Metab 2003; 16: 907-915.
110. Gungor N, Arslanian S. Pathophysiology of type 2 diabetes mellitus in children and adolescents: treatment implications. Treat Endocrinol 2002; 1: 359-371.
111. Benavides S, Striet J, Germak J, Nahata MC. Efficacy and safety of hypoglycemic drugs in children with type 2 diabetes mellitus. Pharmacotherapy 2005; 25: 803-809.
112. Miller JL, Silverstein JH. The management of type 2 diabetes mellitus in children and adolescents. J Pediatr Endocrinol Metab 2005; 18:111-123.