Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice

Journal of Cardiovascular Pharmacology

Volumn 38, Issue 3, 2001, Pages 395-405

  Dol, Frederique ^a   Martin, Genevieve ^a,b   Staels, Bart ^a,c   Mares, Anne Marie ^a   Cazaubon, Catherine ^a   Nisato, Dino ^a   Bidouard, Jean Pierre ^a   Janiak, Philip ^a   Schaeffer, Paul ^a   Herbert, Jean Marc ^a  

^a SANOFI   (France)

^b GENFIT   (France)

^c INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Angiotensin II; Apolipoprotein E; Atherosclerosis; Chemokines; Irbesartan

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; APOLIPOPROTEIN E; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR2; CHOLESTEROL; INTERLEUKIN 8; IRBESARTAN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; ALPHA CHEMOKINE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN RECEPTOR; ANTIHYPERTENSIVE AGENT; BIPHENYL DERIVATIVE; CHEMOKINE RECEPTOR; LIPID; MACROPHAGE INFLAMMATORY PROTEIN 1; TETRAZOLE DERIVATIVE;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LIPOPROTEIN DEFICIENCY; MACROPHAGE; MACROPHAGE MIGRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; ANIMAL; AORTA; ARTERIOSCLEROSIS; BLOOD; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; BIPHENYL COMPOUNDS; CHEMOKINE CCL2; CHEMOKINES, CXC; FEMALE; HUMANS; LIPIDS; MACROPHAGE INFLAMMATORY PROTEIN-1; MACROPHAGES; MICE; MICE, TRANSGENIC; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; RECEPTORS, CHEMOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRAZOLES;

EID: 17944364485     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200109000-00008     Document Type: Article

References (46)

1. Atherosclerosis: An inflammatory disease
2. Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease
3. Tamoxifen decreases cholesterol sevenfold and abolishes lipid lesion development in apolipoprotein E knockout mice
4. A pivotal role of TGF-β in atherogenesis
5. Expression of interleukin-6 in atherosclerotic lesions of male apoE-knockout mice: Inhibition by 17β-estradiol
6. IFNγ potentiates atherosclerosis in apoE knock-out mice
7. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
8. -/- mice reveals a role for chemokines in the initiation of atherosclerosis
9. Monocyte chemoattractant protein-1 in human atheromatous plaques
10. A leukocyte homologue of the IL8 receptor CXCR2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice
11. Interleukin-8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma
12. Interleukin 8 and related chemotactic cytokines
13. Rat KC cDNA cloning and mRNA expression in lung macrophages and fibroblasts
14. Human and bovine granulocyte chemotactic protein-2: Complete amino acid sequence and functional characterization as chemokines
15. Characterization of synthetic human granulocyte chemotactic protein-2: Usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties
16. Identification and characterization of macrophage inflammatory protein-2
17. Molecular cloning of gene sequences regulated by platelet-derived growth factor
18. Angiotensin II induces smooth muscle cell proliferation in the normal and injured arterial wall
19. Angiotensin, LDL peroxidation and atherosclerosis
20. Vascular injury causes neointimal formation in AT1 type la receptor knockout mice
21. Angiotensin II activates the proinflammatory transcription factor nuclear factor κB in human monocytes
22. Angiotensin induces inflammatory activation of human vascular smooth muscle cells
23. Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-kappa B activation and monocyte chemoattractant protein-1 synthesis
24. Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells
25. Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-κB activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis
26. ACE inhibitor quinapril reduces the arterial expression of NFκB-dependent proinflammatory factors but not of collagen I in a rabbit model of atherosclerosis
27. Inhibition of early atherogenesis by losartan in monkeys with diet-induced hypercholesterolemia
28. A review of the new AT1-receptor antagonist irbesartan
29. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
30. Apo E deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
31. Tissue-specific expression of the human gene for lecithin:cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile
32. Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORα
33. Quantitative assessment of atherosclerotic lesions in mice
34. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
35. Anti atherosclerotic and antioxidative effects of captopril in apolipoprotein E-deficient mice
36. Enhanced atherosclerosis and kidney dysfunction in eNOS-/-ApoE-/mice ameliorated by enalapril treatment
37. The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent cf lowering blood pressure in apolipoprotein E deficient mice
38. Oxidative modification of LDL and atherogenesis
39. Interleukin-10 blocks atherosclerotic events in vitro and in vivo
40. Protective role of interleukin-10 in atherosclerosis
41. Localisation of mRNA for JE/MCP-1 and its receptor CCR2 in atherosclerotic lesions of the apoE knockout mouse
42. MIP-1alpha as a critical macrophage chemoattractant in murine wound repair
43. Interleukin 8 as a macrophage derived mediator of angiogenesis
44. Interleukin 8 is chemotactic for vascular smooth muscle cells
45. Modulation of IL-8 receptor expression on purified human lymphocytes is associated with changed chemotactic responses to IL-8
46. Effects of angiotensin II infusion and inhibition of nitric oxide synthase on the rat aorta