메뉴 건너뛰기




Volumn 10, Issue 4, 2006, Pages 334-342

Molecular imaging strategies for drug discovery and development

Author keywords

[No Author keywords available]

Indexed keywords

TARIQUIDAR;

EID: 33746058605     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2006.06.028     Document Type: Review
Times cited : (87)

References (44)
  • 1
    • 12344300543 scopus 로고    scopus 로고
    • Spying on cancer: molecular imaging in vivo with genetically encoded reporters
    • A detailed overview of state-of-the-art molecular imaging strategies using genetically encoded reporters.
    • Gross S., and Piwnica-Worms D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell 7 (2005) 5-15. A detailed overview of state-of-the-art molecular imaging strategies using genetically encoded reporters.
    • (2005) Cancer Cell , vol.7 , pp. 5-15
    • Gross, S.1    Piwnica-Worms, D.2
  • 2
    • 0037313516 scopus 로고    scopus 로고
    • Molecular imaging in drug discovery and development
    • Rudin M., and Weissleder R. Molecular imaging in drug discovery and development. Nat Rev Drug Discov 2 (2003) 123-131
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 123-131
    • Rudin, M.1    Weissleder, R.2
  • 3
    • 27144509160 scopus 로고    scopus 로고
    • Reporter gene imaging: potential impact on therapy
    • Serganova I., and Blasberg R. Reporter gene imaging: potential impact on therapy. Nucl Med Biol 32 (2005) 763-780
    • (2005) Nucl Med Biol , vol.32 , pp. 763-780
    • Serganova, I.1    Blasberg, R.2
  • 4
    • 25144441873 scopus 로고    scopus 로고
    • Molecular imaging in drug discovery and development: potential and limitations of nonnuclear methods
    • Rudin M., Rausch M., and Stoeckli M. Molecular imaging in drug discovery and development: potential and limitations of nonnuclear methods. Mol Imaging Biol 7 (2005) 5-13
    • (2005) Mol Imaging Biol , vol.7 , pp. 5-13
    • Rudin, M.1    Rausch, M.2    Stoeckli, M.3
  • 5
    • 16344363226 scopus 로고    scopus 로고
    • Molecular optical imaging: applications leading to the development of present day therapeutics
    • Shah K., and Weissleder R. Molecular optical imaging: applications leading to the development of present day therapeutics. NeuroRx 2 (2005) 215-225
    • (2005) NeuroRx , vol.2 , pp. 215-225
    • Shah, K.1    Weissleder, R.2
  • 6
    • 4544253691 scopus 로고    scopus 로고
    • Pharmacogenomics: bench to bedside
    • Weinshilboum R., and Wang L. Pharmacogenomics: bench to bedside. Nat Rev Drug Discov 3 (2004) 739-748
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 739-748
    • Weinshilboum, R.1    Wang, L.2
  • 7
    • 0036359767 scopus 로고    scopus 로고
    • Scaling down imaging: molecular mapping of cancer in mice
    • Weissleder R. Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer 2 (2002) 1-8
    • (2002) Nat Rev Cancer , vol.2 , pp. 1-8
    • Weissleder, R.1
  • 8
    • 0042338691 scopus 로고    scopus 로고
    • Tsien RY: Imagining imaging's future. Nat Rev Mol Cell Biol 2003, Suppl:SS16-SS21.
  • 9
    • 0346594332 scopus 로고    scopus 로고
    • In vivo molecular-genetic imaging: multi-modality nuclear and optical combinations
    • Blasberg R.G. In vivo molecular-genetic imaging: multi-modality nuclear and optical combinations. Nucl Med Biol 30 (2003) 879-888
    • (2003) Nucl Med Biol , vol.30 , pp. 879-888
    • Blasberg, R.G.1
  • 10
    • 0141557958 scopus 로고    scopus 로고
    • 18F-paclitaxel in nonhuman primates
    • 18F-labeled Paclitaxel, the authors were able to interrogate the target-specific PD of the Pgp1 modulator XR9576 in vivo.
    • 18F-labeled Paclitaxel, the authors were able to interrogate the target-specific PD of the Pgp1 modulator XR9576 in vivo.
    • (2003) J Nucl Med , vol.44 , pp. 1330-1339
    • Kurdziel, K.1    Kiesewetter, D.2    Carson, R.3    Eckelman, W.4    Herscovitch, P.5
  • 11
    • 15844393513 scopus 로고    scopus 로고
    • Characterization of a gallium-67/gallium-68 radiopharmaceutical for SPECT and PET imaging of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug resistant tumors and at the blood-brain barrier
    • Sharma V., Prior J., Belinsky M., Kruh G., and Piwnica-Worms D. Characterization of a gallium-67/gallium-68 radiopharmaceutical for SPECT and PET imaging of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug resistant tumors and at the blood-brain barrier. J Nucl Med 46 (2005) 354-364
    • (2005) J Nucl Med , vol.46 , pp. 354-364
    • Sharma, V.1    Prior, J.2    Belinsky, M.3    Kruh, G.4    Piwnica-Worms, D.5
  • 13
    • 2542643923 scopus 로고    scopus 로고
    • Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors
    • 68Ga-labeled herceptin. Because HSP90 controls conformational maturation of HER2, monitoring surface levels of HER2 represents a viable strategy to analyze the PD of HSP90 inhibitors.
    • 68Ga-labeled herceptin. Because HSP90 controls conformational maturation of HER2, monitoring surface levels of HER2 represents a viable strategy to analyze the PD of HSP90 inhibitors.
    • (2004) Nat Biotechnol , vol.22 , pp. 701-706
    • Smith-Jones, P.M.1    Solit, D.B.2    Akhurst, T.3    Afroze, F.4    Rosen, N.5    Larson, S.M.6
  • 14
    • 2942529235 scopus 로고    scopus 로고
    • Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy
    • This study represents an excellent example of how small animal imaging is being efficiently applied to validate the pathological specificity and accessibility of molecular targets that were 'panned' from proteomic screens of diseased vs. normal tissues.
    • Oh P., Li Y., Yu J., Durr E., Krasinska K.M., Carver L.A., Testa J.E., and Schnitzer J.E. Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature 429 (2004) 629-635. This study represents an excellent example of how small animal imaging is being efficiently applied to validate the pathological specificity and accessibility of molecular targets that were 'panned' from proteomic screens of diseased vs. normal tissues.
    • (2004) Nature , vol.429 , pp. 629-635
    • Oh, P.1    Li, Y.2    Yu, J.3    Durr, E.4    Krasinska, K.M.5    Carver, L.A.6    Testa, J.E.7    Schnitzer, J.E.8
  • 16
    • 27944496941 scopus 로고    scopus 로고
    • Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
    • Weissleder R., Kelly K., Sun E.Y., Shtatland T., and Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol 23 (2005) 1418-1423
    • (2005) Nat Biotechnol , vol.23 , pp. 1418-1423
    • Weissleder, R.1    Kelly, K.2    Sun, E.Y.3    Shtatland, T.4    Josephson, L.5
  • 17
    • 0344438130 scopus 로고    scopus 로고
    • Near-infrared optical imaging of proteases in cancer
    • Mahmood U., and Weissleder R. Near-infrared optical imaging of proteases in cancer. Mol Cancer Ther 2 (2003) 489-496
    • (2003) Mol Cancer Ther , vol.2 , pp. 489-496
    • Mahmood, U.1    Weissleder, R.2
  • 18
    • 33645419526 scopus 로고    scopus 로고
    • Molecular and cellular imaging of atherosclerosis: emerging applications
    • Jaffer F.A., Libby P., and Weissleder R. Molecular and cellular imaging of atherosclerosis: emerging applications. J Am Coll Cardiol 47 (2006) 1328-1338
    • (2006) J Am Coll Cardiol , vol.47 , pp. 1328-1338
    • Jaffer, F.A.1    Libby, P.2    Weissleder, R.3
  • 19
    • 23944469298 scopus 로고    scopus 로고
    • Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis
    • Bullok K., and Piwnica-Worms D. Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. J Med Chem 48 (2005) 5404-5407
    • (2005) J Med Chem , vol.48 , pp. 5404-5407
    • Bullok, K.1    Piwnica-Worms, D.2
  • 20
    • 11144229887 scopus 로고    scopus 로고
    • Tumor imaging by means of proteolytic activation of cell-penetrating peptides
    • Jiang T., Olson E., Nguyen Q., Roy M., Jennings P., and Tsien R. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci USA 101 (2004) 17867-17872
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17867-17872
    • Jiang, T.1    Olson, E.2    Nguyen, Q.3    Roy, M.4    Jennings, P.5    Tsien, R.6
  • 23
    • 0003215515 scopus 로고    scopus 로고
    • F18-FDG-PET provides early evidence of biological response to ST1571 patients with malignant gastrontestinal stromal tumors (GIST)
    • Van den Abbeele A. F18-FDG-PET provides early evidence of biological response to ST1571 patients with malignant gastrontestinal stromal tumors (GIST). Proc Am Soc Clin Oncol 20 (2001) 362a
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Van den Abbeele, A.1
  • 26
    • 0037447169 scopus 로고    scopus 로고
    • Molecular imaging of protein-protein interactions: controlled expression of p53 and large T antigen fusion proteins in vivo
    • Luker G., Sharma V., Pica C., Prior J., Li W., and Piwnica-Worms D. Molecular imaging of protein-protein interactions: controlled expression of p53 and large T antigen fusion proteins in vivo. Cancer Res 63 (2003) 1780-1788
    • (2003) Cancer Res , vol.63 , pp. 1780-1788
    • Luker, G.1    Sharma, V.2    Pica, C.3    Prior, J.4    Li, W.5    Piwnica-Worms, D.6
  • 27
    • 1642516133 scopus 로고    scopus 로고
    • Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination
    • Safran M., Kim W.Y., Kung A.L., Horner J.W., DePinho R.A., and Kaelin Jr. W.G. Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination. Mol Imaging 2 (2003) 297-302
    • (2003) Mol Imaging , vol.2 , pp. 297-302
    • Safran, M.1    Kim, W.Y.2    Kung, A.L.3    Horner, J.W.4    DePinho, R.A.5    Kaelin Jr., W.G.6
  • 28
    • 9144251024 scopus 로고    scopus 로고
    • Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
    • Uhrbom L., Nerio E., and Holland E.C. Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. Nat Med 10 (2004) 1257-1260
    • (2004) Nat Med , vol.10 , pp. 1257-1260
    • Uhrbom, L.1    Nerio, E.2    Holland, E.C.3
  • 32
    • 0842266703 scopus 로고    scopus 로고
    • Extracellular replication of listeria monocytogenes in the murine gall bladder
    • Hardy J., Francis K.P., DeBoer M., Chu P., Gibbs K., and Contag C.H. Extracellular replication of listeria monocytogenes in the murine gall bladder. Science 303 (2004) 851-853
    • (2004) Science , vol.303 , pp. 851-853
    • Hardy, J.1    Francis, K.P.2    DeBoer, M.3    Chu, P.4    Gibbs, K.5    Contag, C.H.6
  • 33
    • 1542336958 scopus 로고    scopus 로고
    • Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins
    • Yu Y.A., Shabahang S., Timiryasova T.M., Zhang Q., Beltz R., Gentschev I., Goebel W., and Szalay A.A. Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. Nat Biotechnol 22 (2004) 313-320
    • (2004) Nat Biotechnol , vol.22 , pp. 313-320
    • Yu, Y.A.1    Shabahang, S.2    Timiryasova, T.M.3    Zhang, Q.4    Beltz, R.5    Gentschev, I.6    Goebel, W.7    Szalay, A.A.8
  • 34
    • 0036888884 scopus 로고    scopus 로고
    • Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice
    • Luker G., Bardill J., Prior J., Pica C., Piwnica-Worms D., and Leib D. Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice. J Virol 76 (2002) 12149-12161
    • (2002) J Virol , vol.76 , pp. 12149-12161
    • Luker, G.1    Bardill, J.2    Prior, J.3    Pica, C.4    Piwnica-Worms, D.5    Leib, D.6
  • 37
    • 0043027091 scopus 로고    scopus 로고
    • A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene
    • Zhang W., Purchio A.F., Chen K., Wu J., Lu L., Coffee R., Contag P.R., and West D.B. A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene. Drug Metab Dispos 31 (2003) 1054-1064
    • (2003) Drug Metab Dispos , vol.31 , pp. 1054-1064
    • Zhang, W.1    Purchio, A.F.2    Chen, K.3    Wu, J.4    Lu, L.5    Coffee, R.6    Contag, P.R.7    West, D.B.8
  • 40
    • 23144448901 scopus 로고    scopus 로고
    • Real-time imaging of ligand-induced IKK activation in intact cells and in living mice
    • Note that the IκBα-FLuc reporter provides a more temporally proximal readout of NF-κB activation than conventional κB → FLuc reporter gene assays, thereby enabling the readout to coincide with the activity of pharmacological NF-κB modulators.
    • Gross S., and Piwnica-Worms D. Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nat Methods 2 (2005) 607-614. Note that the IκBα-FLuc reporter provides a more temporally proximal readout of NF-κB activation than conventional κB → FLuc reporter gene assays, thereby enabling the readout to coincide with the activity of pharmacological NF-κB modulators.
    • (2005) Nat Methods , vol.2 , pp. 607-614
    • Gross, S.1    Piwnica-Worms, D.2
  • 42
    • 0038378519 scopus 로고    scopus 로고
    • Imaging 26S proteasome activity and inhibition in living mice
    • Luker G., Pica C., Song J., Luker K., and Piwnica-Worms D. Imaging 26S proteasome activity and inhibition in living mice. Nat Med 9 (2003) 969-973
    • (2003) Nat Med , vol.9 , pp. 969-973
    • Luker, G.1    Pica, C.2    Song, J.3    Luker, K.4    Piwnica-Worms, D.5
  • 43
    • 30444445382 scopus 로고    scopus 로고
    • Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production
    • Another example of an elegant study showing the applicability of destabilized genetically encoded reporters for in cellulo and in vivo interrogations of novel inhibitors that act on key regulators of signaling pathways.
    • Safran M., Kim W.Y., O'Connell F., Flippin L., Gunzler V., Horner J.W., Depinho R.A., and Kaelin Jr. W.G. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci USA 103 (2006) 105-110. Another example of an elegant study showing the applicability of destabilized genetically encoded reporters for in cellulo and in vivo interrogations of novel inhibitors that act on key regulators of signaling pathways.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 105-110
    • Safran, M.1    Kim, W.Y.2    O'Connell, F.3    Flippin, L.4    Gunzler, V.5    Horner, J.W.6    Depinho, R.A.7    Kaelin Jr., W.G.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.