Adaptive tolerance in mice upon subchronic exposure to chloroform: Increased exhalation and target tissue regeneration

Toxicology and Applied Pharmacology

Volumn 213, Issue 3, 2006, Pages 267-281

  Anand, Sathanandam S ^a   Philip, Binu K ^a   Palkar, Prajakta S ^a   Mumtaz, Moiz M ^b   Latendresse, John R ^c   Mehendale, Harihara M ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^b AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY   (United States)

^c Pathology Associates International   (United States)

Author keywords

Chloroform; Exhalation; Kidney; Liver; Tissue repair; Tolerance; Toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; CARBON 14; CELL NUCLEUS DNA; CHLOROFORM; CYCLINE; CYTOCHROME P450 2E1; THYMIDINE; TRITIUM; CARBON DIOXIDE; GLUTATHIONE;

ADAPTIVE BEHAVIOR; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DETOXIFICATION; EXHALATION; EXPOSURE; FEEDING; HISTOPATHOLOGY; KIDNEY INJURY; LIVER INJURY; MALE; MOUSE; NONHUMAN; ORGAN INJURY; TISSUE DISTRIBUTION; TISSUE REGENERATION; TOXICOKINETICS; UREA NITROGEN BLOOD LEVEL; ANIMAL; BLOOD; DOSE RESPONSE; DRUG EFFECT; DRUG TOLERANCE; KIDNEY; LIVER; LIVER REGENERATION; LUNG; METABOLISM; PATHOLOGY; PHYSIOLOGY; REGENERATION;

ANIMALS; CARBON DIOXIDE; CHLOROFORM; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; EXHALATION; GLUTATHIONE; KIDNEY; LIVER; LIVER REGENERATION; LUNG; MALE; MICE; REGENERATION;

EID: 33745943873     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.02.007     Document Type: Article

References (39)

1. Anand S.S., and Mehendale H.M. Liver regeneration: a critical toxicodynamic response in the predictive toxicology. Environ. Toxicol. Pharmacol. 18 (2004) 149-160
2. Anand S.S., Soni M.G., Vaidya V.S., Murthy S.N., Mumtaz M.M., and Mehendale H.M. Extent and timeliness of tissue repair determines the dose-related hepatotoxicity of chloroform. Int. J. Toxicol. 22 (2003) 25-33
3. Anand S.S., Murthy S.N., Vaidya V.S., Mumtaz M.M., and Mehendale H.M. Tissue repair plays pivotal role in final outcome of liver injury following chloroform and allyl alcohol binary mixture. Food Chem. Toxicol. 41 (2003) 1123-1132
4. Anand S.S., Murthy S.N., Mumtaz M.M., and Mehendale H.M. Dose-dependent liver tissue repair in chloroform plus thioacetamide acute hepatotoxicity. Environ. Toxicol. Pharmacol. 18 (2004) 143-148
5. Anand S.S., Mumtaz M.M., and Mehendale H.M. Dose-dependent liver regeneration in chloroform, trichloroethylene and allyl alcohol ternary mixture hepatotoxicity in rats. Arch. Toxicol. 79 (2005) 671-682
6. Anand S.S., Mumtaz M.M., and Mehendale H.M. Dose-dependent liver tissue repair after chloroform plus trichloroethylene binary mixture. Basic Clin. Pharmacol. Toxicol. 96 (2005) 436-444
7. Branchflower R.V., Nunn D.S., Highet R.J., Smith J.H., Hook J.B., and Pohl L.R. Nephrotoxicity of chloroform: metabolism to phosgene by the mouse kidney. Toxicol. Appl. Pharmacol. 72 (1984) 159-168
8. Bull R.J., Brown J.M., Meierhenry E.A., Jorgenson T.A., Robinson M., and Stober J.A. Enhancement of the hepatotoxicity of chloroform in B6C3F1 mice by corn oil: Implications for chloroform carcinogenesis. Environ. Health Perspect. 69 (1986) 49-58
9. Burton K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62 (1956) 315-323
10. Butler E., and Dal Pont G. Liquid chromatography electrochemistry procedure for the determination of chlorophenolic compounds in pulp mill effluents and receiving waters. J. Chromatogr. 609 (1992) 113-123
11. Cattely R.C., and Popp J.A. Liver. In: Haschek W., Rousseaux C., and Walig M. (Eds). Handbook of Toxicologic Pathology 2 (2002), Academic Press 187-225
12. Chanda S., Mangipudy R.S., Warbritton A., Bucci T.J., and Mehendale H.M. Stimulated hepatic tissue repair underlies heteroprotection by thioacetamide against acetaminophen-induced lethality. Hepatology 21 (1995) 477-486
13. Chauveau J., Moule Y., and Rouiller C. Isolation of pure and unaltered liver nuclei morphology and biochemical composition. Exp. Cell Res. 11 (1956) 317-321
14. Chipman J.K., Kurukgy M., and Walker C.H. Comparative metabolism of a dieldrin analogue: hepatic microsomal systems as models for metabolism in the whole animal. Biochem. Pharmacol. 28 (1979) 69-75
15. Constan A.A., Sprankle C.S., Peters J.M., Kedderis G.L., Everitt J.I., Wong B.A., Gonzalez F.L., and Butterworth B.E. Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice. Toxicol. Appl. Pharmacol. 160 (1999) 120-126
16. Greenwell A., Foley J.F., and Maronpot R.R. An enhancement method for immunohistochemical staining of proliferating cell nuclear antigen in archival rodent tissues. Cancer Lett. 59 (1991) 251-256
17. Horn T.L., Long L., Cwik M.J., Morrissey R.L., Kapetanovic I.M., and McCormick D.L. Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. Chem. Biol. Interact. 152 (2005) 79-99
18. Larson J.L., Wolf D.C., and Butterworth B.E. Acute hepatotoxic and nephrotoxic effects of chloroform in male F-344 rats and female B6C3F1 mice. Fundam. Appl. Toxicol. 20 (1993) 302-315
19. Larson J.L., Wolf D.C., and Butterworth B.E. Induced cytolethality and regenerative cell proliferation in the livers and kidneys of male B6C3F1 mice given chloroform by gavage. Fundam. Appl. Toxicol. 23 (1994) 537-543
20. Larson J.L., Wolf D.C., and Butterworth B.E. Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: comparison of administration by gavage in corn oil vs ad libitum in drinking water. Fundam. Appl. Toxicol. 22 (1994) 90-102
21. Larson J.L., Templin M.V., Wolf D.C., Jamison K.C., Leininger J.R., Mery S., Morgan K.T., Wong B.A., Conolly R.B., and Butterworth B.E. A 90-day chloroform inhalation study in female and male B6C3F1 mice: implications for cancer risk assessment. Fundam. Appl. Toxicol. 30 (1996) 118-137
22. Lilly P.D., Ross T.M., and Pegram R.A. Trihalomethane comparative toxicity: acute renal and hepatic toxicity of chloroform and bromodichloromethane following aqueous gavage. Fundam. Appl. Toxicol. 40 (1997) 101-110
23. Limaye P.B., Apte U.M., Shankar K., Bucci T.J., Warbritton A., and Mehendale H.M. Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicol. Appl. Pharmacol. 191 (2003) 211-226
24. Mangipudy R.S., and Mehendale H.M. Temporal changes in tissue repair upon repeated exposure to thioacetamide. Toxicol. Appl. Pharmacol. 149 (1998) 254-257
25. Mehendale H.M. Amplified interactive toxicity of chemicals at nontoxic levels: mechanistic considerations and implications to public health. Environ. Health Perspect. 102 (1994) 139-149
26. Mehendale H.M. Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol. Pathol. 33 (2005) 41-51
27. 4 by rats pretreated with chlordecone, mirex, or phenobarbital. Toxicol. Appl. Pharmacol. 93 (1988) 247-256
28. Pereira M.A. Route of administration determines whether chloroform enhances or inhibits cell proliferation in the liver of B6C3F1 mice. Fundam. Appl. Toxicol. 23 (1994) 87-92
29. Rao P.S., Dalu A., Kulkarni S.G., and Mehendale H.M. Stimulated tissue repair prevents lethality in isopropanol-induced potentiation of carbon tetrachloride hepatotoxicity. Toxicol. Appl. Pharmacol. 140 (1996) 235-244
30. Raymond P., and Plaa G.L. Effect of dosing vehicle on the hepatotoxicity of CCl4 and nephrotoxicity of CHCl3 in rats. J. Toxicol. Environ. Health 51 (1997) 463-476
31. Seawright A.A., and McLean A.E.M. The effect of diet on carbon tetrachloride metabolism. Biochem. J. 105 (1967) 1055-1060
32. Smith J.H., Maita K., Sleight S.D., and Hook J.B. Effect of sex hormone status on chloroform nephrotoxicity and renal mixed function oxidases in mice. Toxicology 30 (1984) 305-316
33. Soni M.G., and Mehendale H.M. Role of tissue repair in toxicologic interactions among hepatotoxic organics. Environ. Health Perspect. 106 (1998) 1307-1317
34. Soni M.G., Ramaiah S.K., Mumtaz M.M., Clewell H., and Mehendale H.M. Toxicant-inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology. Regul. Toxicol. Pharmacol. 29 (1999) 165-174
35. Stocker E., and Heine W.D. Regeneration of liver parenchyma under normal and pathological conditions. Beitr. Pathol. 144 (1971) 400-408
36. Templin M.V., Jamison K.C., Sprankle C.S., Wolf D.C., Wong B.A., and Butterworth B.E. Chloroform-induced cytotoxicity and regenerative cell proliferation in the kidneys and liver of BDF1 mice. Cancer Lett. 108 (1996) 225-231
37. Templin M.V., Larson J.L., Butterworth B.E., Jamison K.C., Leininger J.R., Mery S., Morgan K.T., Wong B.A., and Wolf D.C. A 90-day chloroform inhalation study in F-344 rats: profile of toxicity and relevance to cancer studies. Fundam. Appl. Toxicol. 32 (1996) 109-125
38. Templin M.V., Constan A.A., Wolf D.C., Wong B.A., and Butterworth B.E. Patterns of chloroform-induced regenerative cell proliferation in BDF1 mice correlate with organ specificity and dose-response of tumor formation. Carcinogenesis 19 (1998) 187-193
39. Vaidya V.S., Shankar K., Lock E.A., Bucci T.J., and Mehendale H.M. Renal injury and repair following S-1,2 dichlorovinyl-l-cysteine administration to mice. Toxicol. Appl. Pharmacol. 188 (2003) 110-121