Liver regeneration: A critical toxicodynamic response in predictive toxicology

Environmental Toxicology and Pharmacology

Volumn 18, Issue 2, 2004, Pages 149-160

  Anand, Sathanandam S ^a   Mehendale, Harihara M ^a  

^a Department of Toxicology   (United States)

Author keywords

Chemical mixtures; Dose response; Hepatotoxicity; Risk assessment; Tissue repair

Indexed keywords

ALANINE AMINOTRANSFERASE; ALLYL ALCOHOL; CHLOROFORM; DNA; THIOACETAMIDE; THYMIDINE DERIVATIVE; TRICHLOROETHYLENE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; CONCENTRATION RESPONSE; DISEASE COURSE; HISTOPATHOLOGY; LIVER INJURY; LIVER REGENERATION; LIVER TOXICITY; MORTALITY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; REMISSION; REVIEW; RISK ASSESSMENT; SURVIVAL; TISSUE REPAIR; TOXICOLOGY;

CHANDA; RUBUS MOLUCCANUS;

EID: 8144222113     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2004.02.011     Document Type: Article

References (70)

1. S.K. Abdul-Hussain, and H.M. Mehendale Ongoing hepatocellular regeneration and resiliency toward galactosamine hepatotoxicity Arch. Toxicol. 66 1992 729
2. S.S. Anand, S.S. Devi, M. Murali, M.M. Mumtaz, and H.M. Mehendale Higher Urinary elimination of trichloroethylene in presence of chloroform results in lower liver injury Int. J. Toxicol. 21 6 2002 525
3. S.S. Anand, M.G. Soni, V.S. Vaidya, S.N. Murthy, M.M. Mumtaz, and H.M. Mehendale Extent and timeliness of tissue repair determines the dose-related hepatotoxicity of chloroform Int. J. Toxicol. 22 2003 25
4. S.S. Anand, S.N. Murthy, V.S. Vishal, M.M. Mumtaz, and H.M. Mehendale Tissue repair plays pivotal role in final outcome of supra-additive liver injury after chloroform and allyl alcohol binary mixture Food Chem. Toxicol. 41 2003 1123
5. S.S. Anand, V.S. Vaidya, B. Murali, M.M. Mumtaz, and H.M. Mehendale Hepatotoxicity of chloroform, trichloroethylene, and allyl alcohol ternary mixture is less than additive Toxicologist 72 2003 671
6. S.S. Anand, S.N. Murthy, V.S. Vishal, M.M. Mumtaz, and H.M. Mehendale Dose-dependant liver tissue repair in chloroform plus thioacetamide acute hepatotoxicity Environ. Toxicol. Pharmacol. 28 2004 143 148
7. U.M. Apte, P.B. Limaye, S.K. Ramaiah, V.S. Vaidya, T.J. Bucci, A. Warbritton, and H.M. Mehendale Upregulated promitogenic signaling via cytokines and growth factors: potential mechanism behind robust liver tissue repair in calorie-restricted rats upon toxic challenge Toxicol. Sci. 69 2002 448
8. D.S. Bae, C. Gennings, Carter W.H.Jr., R.S. Yang, and J.A. Campain Toxicological interactions among arsenic, cadmium, chromium, and lead in human keratinocytes Toxicol. Sci. 63 2001 132
9. L.M. Bornheim Effect of cytochrome P-450 inducers on cocaine mediated hepatotoxicity Toxicol. Appl. Pharmacol. 150 1998 158
10. K.A. Burton A study of the conditions and mechanisms of the diphenylamine reaction for positive colorimetric estimation of DNA Biochem. J. 62 1956 315
11. S.Z. Cagen, and C.D. Klaassen Hepatotoxicity of carbon tetrachloride in developing rats Toxicol. Appl. Pharmacol. 50 1979 347
12. Z. Cai, and H.M. Mehendale Hepatotoxicity and lethality of halomethanes in Mongolian gerbils pretreated with chlordecone, phenobarbital or mirex Arch. Toxicol. 65 1991 204
13. Z. Cai, and H.M. Mehendale Resiliency to amplification of carbon tetrachloride hepatotoxicity by chlordecone during postnatal development in rats Pediatr. Res. 33 1993 225
14. E.J. Calabrese, and H.M. Mehendale A review of the role of tissue repair as an adaptive strategy: why low doses are often non-toxic and why high doses can be fatal Food Chem. Toxicol. 34 1996 301
15. S. Chanda, R.S. Mangipudy, A. Warbritton, T.J. Bucci, and H.M. Mehendale Stimulated hepatic tissue repair underlies heteroprotection by thioacetamide against acetaminophen-induced lethality Hepatology 21 1995 477
16. S. Chanda, and H.M. Mehendale Nutritional impact on the final outcome of liver injury inflicted by model hepatotoxicants: effect of glucose loading FASEB J. 9 1995 240
17. S. Chanda, and H.M. Mehendale Hepatic cell division and tissue repair: a key to survival after liver injury Mol. Med. Today 2 1996 83
18. L.W. Chang, M.A. Pereira, and J.E. Klaunig Cytotoxicity of halogenated alkanes in primary cultures of rat hepatocytes from normal, partial hepatectomized, and preneoplastic/neoplastic liver Toxicol. Appl. Pharmacol. 80 1985 274
19. J. Chauveau, Y. Moule, and C.M. Roniller Isolation of pure and unaltered liver nuclei morphology and biochemical composition Exp. Cell. Res. 11 1956 317
20. A.H. Conney Pharmacology implications of microsomal enzyme induction Pharmacol. Rev. 19 1967 317
21. R.B. Conolly, and B.E. Butterworth Biologically based dose response model for hepatic toxicity: a mechanistically based replacement for traditional estimates of noncancer risk Toxicol. Lett. 82 1995 901
22. K. Dalhoff, H. Lausen, K. Bangert, H.E. Poulsen, M.E. Anderson, N. Grunnet, and N. Tygstrup Autoprotection in acetaminophen intoxication in rats: the role of liver regeneration Pharmacol. Toxicol. 88 2001 135
23. A. Dalu, G.M. Cronin, B.D. Lyn-Cook, and H.M. Mehendale Age-related differences in TGF-alpha and proto-oncogenes expression in rat liver after a low dose of carbon tetrachloride J. Biochem. Toxicol. 10 1995 259
24. 4 hepatotoxicity Toxicology 111 1996 29
25. A. Dalu, P.S. Rao, and H.M. Mehendale Colchicine antimitosis abolishes resiliency of postnatally developing rats to chlordecone-amplified carbon tetrachloride hepatotoxicity and lethality Environ. Health Perspect. 106 1998 597
26. S.S. Devi, and H.M. Mehendale Inhibited tissue repair in thioacetamide treated diabetic rats: NF-κB as a ringmaster Toxicologist. 78 2004 1052
27. S.S. Digavalli, and H.M. Mehendale 2-Butoxyethanol autoprotection is due to resiliency of newly formed erythrocytes to hemolysis Arch. Toxicol. 69 1995 526
28. I.D. Dobrev, M.E. Andersen, and R.S. Yang Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling Arch. Toxicol. 75 2001 134
29. S. Haddad, G. Charest-Tardif, and K. Krishnan Physiologically based modeling of the maximal effect of metabolic interactions on the kinetics of components of complex chemical mixtures J. Toxicol. Environ. Health A 61 2000 209
30. N. Hecht, O. Pappo, D. Shouval, S. Rose-John, E. Galun, and J.H. Axelrod Hyper-IL-6 gene therapy reverses fulminant hepatic failure Mol. Ther. 3 2001 683
31. K.D. Horn, P. Wax, S.M. Schneider, T.G. Martin, J.S. Nine, A. Moraca, M.A. Virji, P.A. Aronica, and K.N. Rao Biomarkers of liver regeneration allow early prediction of hepatic recovery after acute necrosis Am. J. Clin. Pathol. 112 1999 351
32. D. Jonker, R.A. Woutersen, and V.J. Feron Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action Food Chem. Toxicol. 34 1996 1075
33. S.G. Kulkarni, H. Duong, R. Gomila, and H.M. Mehendale Strain differences in tissue repair response to 1,2-dichlorobenzene Arch. Toxicol. 70 1996 714
34. S.G. Kulkarni, A.J. Harris, D.A. Casciano, and H.M. Mehendale Differential protooncogene expression in Sprague-Dawley and Fischer 344 rats during 1,2-dichlorobenzene-induced hepatocellular regeneration Toxicology 139 1999 119
35. S.G. Kulkarni, A. Warbritton, T.J. Bucci, and H.M. Mehendale Antimitotic intervention with colchicine alters the outcome of o-DCB-induced hepatotoxicity in Fischer 344 rats Toxicology 120 1997 79
36. P.B. Limaye, U.M. Apte, K. Shankar, T.J. Bucci, A. Warbritton, and H.M. Mehendale Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants Toxicol. Appl. Pharmacol. 191 2003 211
37. P.B. Limaye, U.M. Apte, P.S. Palkar, J.R. Latendresse, S. Yu, P. Kashireddy, J.K. Reddy, and H.M. Mehendale Calpastatin expression: a new line of defense against progression of toxican-induced injury Toxicologist. 78 2004 63
38. R.S. Mangipudy, S. Chanda, and H.M. Mehendale Tissue repair response as a function of dose in thioacetamide hepatotoxicity Environ. Health Perspect. 103 1995 260
39. R.S. Mangipudy, S. Chanda, and H.M. Mehendale Hepatocellular regeneration: key to thioacetamide autoprotection Pharmacol. Toxicol. 77 1995 182
40. R.S. Mangipudy, P.S. Rao, and H.M. Mehendale Effect of an antimitotic agent colchicine on thioacetamide hepatotoxicity Environ. Health Perspect. 104 1996 744
41. H.M. Mehendale Role of hepatocellular regeneration and hepatolobular healing in in the final outcome of liver injury A two-stage model toxicity Biochem. Pharmacol. 42 1991 1155
42. H.M. Mehendale Amplified interactive toxicity of chemicals at nontoxic levels: mechanistic considerations and implications to public health Environ. Health Perspect. 102 1994 139
43. H.M. Mehendale Toxicodynamics of low level toxicant interactions of biological significance: inhibition of tissue repair Toxicology 105 1995 251
44. H.M. Mehendale, K.N. Thakore, and C.V. Rao Autoprotection: stimulated tissue repair permits recovery from injury J. Biochem. Toxicol. 9 1994 131
45. B. Murali, M.C. Korrapati, A. Warbritton, J.R. Latendresse, and H.M. Mehendale Tolerance of aged Fischer 344 rats against chlorodecone-amplified carbon tetrachloride toxicity Mech. Ageing Develop. 125 2004 421
46. W.A. Pott, S.A. Benjamin, and R.S. Yang Antagonistic interactions of an arsenic-containing mixture in a multiple organ carcinogenicity bioassay Cancer Lett. 133 1998 185
47. S.K. Ramaiah, U.M. Apte, and H.M. Mehendale Dietary restriction as a protective mechanism in non-cancer toxicity outcomes: a review Int. J. Toxicol. 19 2000 1
48. 4 hepatotoxicity: a novel dose-response Toxicology 118 1997 181
49. K.N. Rao, M.A. Virji, M.A. Moraca, W.F. Diven, T.G. Martin, and S.M. Schneider Role of serum markers for liver function and liver regeneration in the management of chloroform poisoning J. Anal. Toxicol. 17 1993 99
50. P.S. Rao, A. Dalu, S.G. Kulkarni, and H.M. Mehendale Stimulated tissue repair prevents lethality in isopropanol-induced potentiation of carbon tetrachloride hepatotoxicity Toxicol. Appl. Pharmacol. 140 1996 235
51. 4 autoprotection Toxicol. Pathol. 19 1991 597
52. 4 treated rats Biochem. Pharmacol. 42 1991 2323
53. V.C. Rao, and H.M. Mehendale Effect of antimitotic agent colchicine on carbon tetrachloride toxicity Arch. Toxicol. 67 1993 392
54. E. Roberts, B.M. Ahlerwalia, G. Lee, C. Chan, D.S.R. Sharma, and E. Farber Resistance to hepatotoxins acquired by hepatocytes during liver regeneration Cancer Res. 43 1983 28
55. R.J. Ruch, J.E. Klaunig, and M.A. Pereira Selective resistance to cytotoxic agents in hepatocytes isolated from partially hepatectomized and neoplastic mouse liver Cancer Lett. 26 1985 295
56. K. Sakai, N. Murata, and Y. Yamane Effect of copper and cadmium pretreatments on DNA synthesis and thymidine kinase activity in the liver of dimethylnitrosamine-treated and partially hepatectomized rats Gann 74 1983 663
57. S.P. Sawant, A.V. Dnyanmote, K. Shankar, P.B. Limaye, J.R. Latendresse, and H.M. Mehendale Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats J. Pharmacol. Exp. Ther. 308 2004 690
58. S.D. Sawant, P.G. Doucet, W. Slob, B.L. Blaylock, and H.M Mehendale Experimental mathematical validation of novel concept of extended 2-butoxyethanol autoprotection Int. J. Toxicol. 18 1999 307
59. K. Shankar, V.S. Vaidya, C.J. Corton, T.J. Bucci, and H.M. Mehendale Activation of PPAR-α in streptozotcin-induced diabetes is essential for resistance against acetaminophen toxicity FASEB J. 17 2003 1748
60. M.G. Soni, and H.M. Mehendale Role of tissue repair in toxicological interactions among hepatotoxic organics Environ. Health Perspect. 106 1998 1301
61. M.G. Soni, and H.M. Mehendale Toxicological interactions among organics Environ. Health Perspect. 106 6 1998 1307
62. M.G. Soni, R.S. Mangipudy, M.M. Mumtaz, and H.M. Mehendale Tissue repair response as a function of dose during trichloroethylene hepatotoxicity Toxicol. Sci. 42 1998 158
63. M.G. Soni, S.K. Ramaiah, M.M. Mumtaz, H. Clewell, and H.M. Mehendale Toxicant-inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology Regul. Phramcol. Toxicol. 19 1999 165
64. 4 autoprotection Toxicol. Pathol. 19 1991 47
65. 4 autoprotection Toxicol. Pathol. 22 1994 291
66. -/-) mice J. Hepatol. 33 2000 967
67. T. Wang, R.D. Fontenot, M.G. Soni, T.J. Bucci, and H.M. Mehendale Enhanced hepatotoxicity and toxic outcome of thioacetamide in streptozotocin-induced diabetic rats Toxicol. Appl. Pharmacol. 166 2000 92
68. E. Webber, M. Bruix, R.H. Pierce, and N. Fausto Tumor necrosis factor primes hepatocytes for DNA replication in the rat Hepatology 28 1998 1226
69. J. Whysner Phenobarbital mechanistic data and risk assessment: enzyme induction enhanced cell proliferation and tumor promotion Pharmacol. Ther. 71 1998 153
70. F. Wroblewski, and J.S. LaDue Serum glutamic-pyruvic transaminase in cardiac and Hepatic disease Proc. Soc. Exp. Biol. Med. 91 1956 569