-
2
-
-
0020540151
-
The protein phosphatases involved in cellular regulation. 1. Classification and substrate specificities
-
Ingebritsen TS, Cohen P (1983) The protein phosphatases involved in cellular regulation. 1. Classification and substrate specificities. Eur J Biochem 132:255-261
-
(1983)
Eur J Biochem
, vol.132
, pp. 255-261
-
-
Ingebritsen, T.S.1
Cohen, P.2
-
3
-
-
0030296869
-
Molecular mechanisms of the protein serine/threonine phosphatases
-
Barford D (1996) Molecular mechanisms of the protein serine/threonine phosphatases. Trends Biochem Sci 21:407-412
-
(1996)
Trends Biochem Sci
, vol.21
, pp. 407-412
-
-
Barford, D.1
-
4
-
-
0345118287
-
Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family
-
Komaki K, Katsura K, Ohnishi M, et al. (2003) Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family. Biochim Biophys Acta 1630:130-137
-
(2003)
Biochim Biophys Acta
, vol.1630
, pp. 130-137
-
-
Komaki, K.1
Katsura, K.2
Ohnishi, M.3
-
5
-
-
15944406764
-
PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
Gao T, Furnari F, Newton AC (2005) PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18:13-24
-
(2005)
Mol Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
6
-
-
0025915269
-
Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion
-
Moore F, Weekes J, Hardie DG (1991) Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion. Eur J Biochem 199:691-697
-
(1991)
Eur J Biochem
, vol.199
, pp. 691-697
-
-
Moore, F.1
Weekes, J.2
Hardie, D.G.3
-
7
-
-
0029561919
-
5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC
-
Davies SP, Helps NR, Cohen PT, Hardie DG (1995) 5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC. FEBS Lett 377:421-425
-
(1995)
FEBS Lett
, vol.377
, pp. 421-425
-
-
Davies, S.P.1
Helps, N.R.2
Cohen, P.T.3
Hardie, D.G.4
-
8
-
-
0031567606
-
Specificity of different isoforms of protein phosphatase-2A and protein phosphatase-2C studied using site-directed mutagenesis of HMG-CoA reductase
-
Ching YP, Kobayashi T, Tamura S, Hardie DG (1997) Specificity of different isoforms of protein phosphatase-2A and protein phosphatase-2C studied using site-directed mutagenesis of HMG-CoA reductase. FEBS Lett 411:265-268
-
(1997)
FEBS Lett
, vol.411
, pp. 265-268
-
-
Ching, Y.P.1
Kobayashi, T.2
Tamura, S.3
Hardie, D.G.4
-
9
-
-
0037515747
-
Cell cycle regulation and p53 activation by protein phosphatase 2C alpha
-
Ofek P, Ben-Meir D, Kariv-Inbal Z, Oren M, Lavi S (2003) Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. J Biol Chem 278:14299-14305
-
(2003)
J Biol Chem
, vol.278
, pp. 14299-14305
-
-
Ofek, P.1
Ben-Meir, D.2
Kariv-Inbal, Z.3
Oren, M.4
Lavi, S.5
-
10
-
-
0032561413
-
Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells
-
Hanada M, Kobayashi T, Ohnishi M, et al (1998) Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells. FEBS Lett 437:172-176
-
(1998)
FEBS Lett
, vol.437
, pp. 172-176
-
-
Hanada, M.1
Kobayashi, T.2
Ohnishi, M.3
-
11
-
-
0035937111
-
Regulation of the TAK1 signaling pathway by protein phosphatase 2C
-
Hanada M, Ninomiya-Tsuji J, Komaki K, et al (2001) Regulation of the TAK1 signaling pathway by protein phosphatase 2C. J Biol Chem 276:5753-5759
-
(2001)
J Biol Chem
, vol.276
, pp. 5753-5759
-
-
Hanada, M.1
Ninomiya-Tsuji, J.2
Komaki, K.3
-
12
-
-
0037410205
-
Protein phosphatase type 2C dephosphorylates BAD
-
Klumpp S, Selke D, Krieglstein J (2003) Protein phosphatase type 2C dephosphorylates BAD. Neurochem Int 42:555-560
-
(2003)
Neurochem Int
, vol.42
, pp. 555-560
-
-
Klumpp, S.1
Selke, D.2
Krieglstein, J.3
-
14
-
-
0036063636
-
Relationship between protein phosphatase type-2C activity and induction of apoptosis in cultured neuronal cells
-
Klumpp S, Selke D, Ahlemeyer B, Schaper C, Krieglstein J (2002) Relationship between protein phosphatase type-2C activity and induction of apoptosis in cultured neuronal cells. Neurochem Int 41:251-259
-
(2002)
Neurochem Int
, vol.41
, pp. 251-259
-
-
Klumpp, S.1
Selke, D.2
Ahlemeyer, B.3
Schaper, C.4
Krieglstein, J.5
-
15
-
-
14544273265
-
Oleic acid causes apoptosis and dephosphorylates Bad
-
Zhu Y, Schwarz S, Ahlemeyer B, Grzeschik S, Klumpp S, Krieglstein J (2005) Oleic acid causes apoptosis and dephosphorylates Bad. Neurochem Int 46:127-135
-
(2005)
Neurochem Int
, vol.46
, pp. 127-135
-
-
Zhu, Y.1
Schwarz, S.2
Ahlemeyer, B.3
Grzeschik, S.4
Klumpp, S.5
Krieglstein, J.6
-
16
-
-
23044504361
-
Unsaturated fatty acids isolated from human lipoproteins activate protein phosphatase type 2Cbeta and induce apoptosis in endothelial cells
-
Hufnagel B, Dworak M, Soufi M, et al (2005) Unsaturated fatty acids isolated from human lipoproteins activate protein phosphatase type 2Cbeta and induce apoptosis in endothelial cells. Atherosclerosis 180:245-254
-
(2005)
Atherosclerosis
, vol.180
, pp. 245-254
-
-
Hufnagel, B.1
Dworak, M.2
Soufi, M.3
-
17
-
-
0031602559
-
Separation of protein phosphatase type 2C isozymes by chromatography on blue sepharose
-
Klumpp S, Selke D (1998) Separation of protein phosphatase type 2C isozymes by chromatography on blue sepharose. Methods Mol Biol 93:213-218
-
(1998)
Methods Mol Biol
, vol.93
, pp. 213-218
-
-
Klumpp, S.1
Selke, D.2
-
18
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture. Nature 411:494-498
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
19
-
-
0023691731
-
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics
-
Biajolan C, Takai A (1988) Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. Biochem J 256:283-290
-
(1988)
Biochem J
, vol.256
, pp. 283-290
-
-
Biajolan, C.1
Takai, A.2
-
20
-
-
0025333146
-
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants
-
MacKintosh C, Beattie KA, Klumpp S, Cohen P, Codd GA (1990) Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett 264:187-192
-
(1990)
FEBS Lett
, vol.264
, pp. 187-192
-
-
MacKintosh, C.1
Beattie, K.A.2
Klumpp, S.3
Cohen, P.4
Codd, G.A.5
-
21
-
-
0033692758
-
Oleate activates phosphoatidylinositol 3-kinase and promotes proliferaton and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects
-
Hardy S, Langelier Y, Prentki M (2000) Oleate activates phosphoatidylinositol 3-kinase and promotes proliferaton and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects. Cancer Res 60:6353-6358
-
(2000)
Cancer Res
, vol.60
, pp. 6353-6358
-
-
Hardy, S.1
Langelier, Y.2
Prentki, M.3
-
22
-
-
0036924861
-
Different role of saturated and unsaturated fatty acids in β-cell apoptosis
-
Eitel K, Staiger H, Brendel MD, et al (2002) Different role of saturated and unsaturated fatty acids in β-cell apoptosis. Biochem Biophys Res Commun 299:853-856
-
(2002)
Biochem Biophys Res Commun
, vol.299
, pp. 853-856
-
-
Eitel, K.1
Staiger, H.2
Brendel, M.D.3
-
23
-
-
0037453292
-
Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cells
-
Lu Z, Mu YM, Wang BA, et al (2003) Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cells. Biochem Biophys Res Commun 303:1002-1007
-
(2003)
Biochem Biophys Res Commun
, vol.303
, pp. 1002-1007
-
-
Lu, Z.1
Mu, Y.M.2
Wang, B.A.3
-
25
-
-
0345831084
-
Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors
-
Cheng J, Ogawa K, Kuriki K, et al (2003) Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors. Cancer Lett 193:17-24
-
(2003)
Cancer Lett
, vol.193
, pp. 17-24
-
-
Cheng, J.1
Ogawa, K.2
Kuriki, K.3
-
26
-
-
0037329496
-
Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line
-
Healy DA, Watson R, Newsholme P (2003) Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line. Clin Sci 104:171-179
-
(2003)
Clin Sci
, vol.104
, pp. 171-179
-
-
Healy, D.A.1
Watson, R.2
Newsholme, P.3
-
27
-
-
0037147215
-
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1)
-
Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ (2002) Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1). J Biol Chem 277:49676-49684
-
(2002)
J Biol Chem
, vol.277
, pp. 49676-49684
-
-
Wrede, C.E.1
Dickson, L.M.2
Lingohr, M.K.3
Briaud, I.4
Rhodes, C.J.5
-
28
-
-
0016691920
-
Fatty acid binding to plasma albumin
-
Spector AA (1975) Fatty acid binding to plasma albumin. J Lipid Res 16:165-179
-
(1975)
J Lipid Res
, vol.16
, pp. 165-179
-
-
Spector, A.A.1
-
30
-
-
0034634370
-
Cristallographic analysis reveals common modes of binding of medium- and long-chain fatty acids to human serum albumin
-
Bhattacharya AA, Grune T, Curry S (2000) Cristallographic analysis reveals common modes of binding of medium- and long-chain fatty acids to human serum albumin. J Mol Biol 303:721-732
-
(2000)
J Mol Biol
, vol.303
, pp. 721-732
-
-
Bhattacharya, A.A.1
Grune, T.2
Curry, S.3
-
31
-
-
2942580733
-
Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids
-
Clark H, Carling D, Saggerson D (2004) Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids. Eur J Biochem 271:2215-2224
-
(2004)
Eur J Biochem
, vol.271
, pp. 2215-2224
-
-
Clark, H.1
Carling, D.2
Saggerson, D.3
-
32
-
-
2942597678
-
Identification of hydrophobic interactions between proteins and lipids: Free fatty acids activate phospholipase Cδ1 via allosterism
-
Kobayashai M, Mutharasan RK, Feng J, Roberts MF, Lomasney JW (2004) Identification of hydrophobic interactions between proteins and lipids: Free fatty acids activate phospholipase Cδ1 via allosterism. Biochemistry 43:7522-7533
-
(2004)
Biochemistry
, vol.43
, pp. 7522-7533
-
-
Kobayashai, M.1
Mutharasan, R.K.2
Feng, J.3
Roberts, M.F.4
Lomasney, J.W.5
-
33
-
-
0019918165
-
Fatty acid activation and temperature pertubation of rat brain microsomal phospholipase D
-
Chalifour R, Kanfer JN (1982) Fatty acid activation and temperature pertubation of rat brain microsomal phospholipase D. J Neurochem 39:299-305
-
(1982)
J Neurochem
, vol.39
, pp. 299-305
-
-
Chalifour, R.1
Kanfer, J.N.2
-
36
-
-
0023738090
-
Effect of oleic acid on mitochondrial oxidative phosphorylation in rat brain slices
-
Ogawa M, Yoshida S, Ogawa T, Shimada T, Takeshita M (1988) Effect of oleic acid on mitochondrial oxidative phosphorylation in rat brain slices. Biochem Int 17:773-782
-
(1988)
Biochem Int
, vol.17
, pp. 773-782
-
-
Ogawa, M.1
Yoshida, S.2
Ogawa, T.3
Shimada, T.4
Takeshita, M.5
-
37
-
-
0036846007
-
Mitochondrial oxidative stress is modulated by oleic acid via an epidermal growth factor receptor-dependent activation of glutathione peroxidase
-
Duval C, Auge N, Frisach MF, Casteilla L, Salvayre R, Negre-Salvayre A (2002) Mitochondrial oxidative stress is modulated by oleic acid via an epidermal growth factor receptor-dependent activation of glutathione peroxidase. Biochem J 367:889-894
-
(2002)
Biochem J
, vol.367
, pp. 889-894
-
-
Duval, C.1
Auge, N.2
Frisach, M.F.3
Casteilla, L.4
Salvayre, R.5
Negre-Salvayre, A.6
-
38
-
-
0037230114
-
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1
-
Maestre I, Jordan J, Calvo S, et al (2003) Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1. Endocrinology 144:335-345
-
(2003)
Endocrinology
, vol.144
, pp. 335-345
-
-
Maestre, I.1
Jordan, J.2
Calvo, S.3
-
39
-
-
0942290430
-
Fatty acids enhance membrane permeabilization by pro-apoptotic Bax
-
Epand RF, Martinou JC, Montessuit S, Epand RM (2004) Fatty acids enhance membrane permeabilization by pro-apoptotic Bax. Biochem J 377:509-516
-
(2004)
Biochem J
, vol.377
, pp. 509-516
-
-
Epand, R.F.1
Martinou, J.C.2
Montessuit, S.3
Epand, R.M.4
-
40
-
-
0344010951
-
Polyunsaturated fatty acids induce cell death in YAC-1 lymphoma by a caspase-3-independent mechanism
-
Puertollano MA, de Pablo MA, Alvarez de Cienfuegos G (2003) Polyunsaturated fatty acids induce cell death in YAC-1 lymphoma by a caspase-3-independent mechanism. Anticancer Res 23:3905-3910
-
(2003)
Anticancer Res
, vol.23
, pp. 3905-3910
-
-
Puertollano, M.A.1
De Pablo, M.A.2
Alvarez De Cienfuegos, G.3
-
41
-
-
14844283705
-
Regulation of reactive oxygen species (ROS) production by C18 fatty acids in Jurkat and Raji cells
-
Cury-Boaventura MF, Curi R (2005) Regulation of reactive oxygen species (ROS) production by C18 fatty acids in Jurkat and Raji cells. Clin Sci 108:245-253
-
(2005)
Clin Sci
, vol.108
, pp. 245-253
-
-
Cury-Boaventura, M.F.1
Curi, R.2
-
42
-
-
27644537569
-
The mechanism of apoptosis by the oleic acid in HeLa cells: Caspase-independent pathway by induction of IκBβ
-
Mizotani K, Inoue I (2002) The mechanism of apoptosis by the oleic acid in HeLa cells: caspase-independent pathway by induction of IκBβ. J Saitama Med School 29:117-123
-
(2002)
J Saitama Med School
, vol.29
, pp. 117-123
-
-
Mizotani, K.1
Inoue, I.2
-
43
-
-
4243164468
-
Comparative toxicity of oleic acid and linoleic acid on Jurkat cells
-
Cury-Boaventura MF, Pompeia C, Curi R (2004) Comparative toxicity of oleic acid and linoleic acid on Jurkat cells. Clin Nutr 23:721-732
-
(2004)
Clin Nutr
, vol.23
, pp. 721-732
-
-
Cury-Boaventura, M.F.1
Pompeia, C.2
Curi, R.3
-
44
-
-
0027194474
-
A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptors from biological extracts: Characterization of peroxisome proliferator-activated receptor activators in plasma
-
Banner CD, Gottlicher M, Widmark E, Sjovall J, Rafter JJ, Gustafsson JA (1993) A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptors from biological extracts: characterization of peroxisome proliferator-activated receptor activators in plasma. J Lipid Res 34:1583-1591
-
(1993)
J Lipid Res
, vol.34
, pp. 1583-1591
-
-
Banner, C.D.1
Gottlicher, M.2
Widmark, E.3
Sjovall, J.4
Rafter, J.J.5
Gustafsson, J.A.6
-
45
-
-
0030047806
-
Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α-β/δ and -γ in the adult rat
-
Braissant O, Foufelle F, Scott C, Dauca M, Wahli W (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α-β/δ and -γ in the adult rat. Endocrinology 137:354-366
-
(1996)
Endocrinology
, vol.137
, pp. 354-366
-
-
Braissant, O.1
Foufelle, F.2
Scott, C.3
Dauca, M.4
Wahli, W.5
-
46
-
-
0031930111
-
Distribution of mRNA encoding the peroxisome proliferator-activated receptor α, β, and γ and the retinoic receptors α, β, and γ in rat. nervous system
-
Cullingford TE, Bhakoo K, Peuchen S, Dolphin CT, Patel R, Clark JB (1996) Distribution of mRNA encoding the peroxisome proliferator-activated receptor α, β, and γ and the retinoic receptors α, β, and γ in rat. nervous system. J Neurochem 70:1366-1375
-
(1996)
J Neurochem
, vol.70
, pp. 1366-1375
-
-
Cullingford, T.E.1
Bhakoo, K.2
Peuchen, S.3
Dolphin, C.T.4
Patel, R.5
Clark, J.B.6
-
47
-
-
0035956863
-
Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α and γ-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus
-
USA
-
Wolfrum C, Borman CM, Borchers T, Spener F (2001) Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α and γ-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus. Proc Natl Acad Sci USA 98:2323-2328
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 2323-2328
-
-
Wolfrum, C.1
Borman, C.M.2
Borchers, T.3
Spener, F.4
|