Polyunsaturated Fatty Acids Induce Cell Death in YAC-1 Lymphoma by a Caspase-3-independent Mechanism

Anticancer Research

Volumn 23, Issue 5 A, 2003, Pages 3905-3910

  Puertollano, Maria A ^a   De Pablo, Manuel A ^a   De Cienfuegos, Gerardo Alvarez ^a  

^a UNIVERSITY OF JAÉN   (Spain)

Author keywords

Apoptosis; Caspase 3; Fatty acids; Reactive oxygen species; YAC 1 cells

Indexed keywords

ARACHIDONIC ACID; CASPASE 3; DNA FRAGMENT; FAT DROPLET; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; OLEIC ACID; POLYUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE; STEARIC ACID; TRIACYLGLYCEROL;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; LIPID STORAGE; LYMPHOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE GENETICS; STATISTICAL SIGNIFICANCE; TUMOR CELL;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL LINE, TUMOR; CELL MEMBRANE; DNA FRAGMENTATION; FATTY ACIDS, UNSATURATED; FLUORESCENT DYES; LYMPHOMA; MEMBRANE LIPIDS; MICE; ORGANIC CHEMICALS; OXAZINES; REACTIVE OXYGEN SPECIES;

EID: 0344010951     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Penninger JM and Kroemer G: Molecular and cellular mechanisms of T lymphocyte apoptosis. Adv Immunol 68: 51-144, 1998.
2. Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462, 1995.
3. Arita K, Kobuchu H, Utsumi T, Takehara Y, Akiyama J, Horton AA and Utsumi K: Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids. Biochem Pharm 62: 821-8, 2001.
4. Kurita-ochiai T, Ochiai K and Fukushima K: Butyric acid-induced T-cell apoptosis is mediated by caspase-8 and -9 activation in a Fas-independent manner. Clin Diagn Lab Immunol 8: 325-332, 2001.
5. de Pablo MA, Susin SA, Jacotot E, Larochette N, Costantini P, Ravagnan L, Zamzami N and Kroemer G: Palmitate induces apoptosis via a direct effect on mitochondria. Apoptosis 4: 81-87, 1999.
6. de Pablo MA and Alvarez de Cienfuegos G: Modulatory effects of dietary lipids on immune system functions. Immunol Cell Biol 78: 31-39, 2000.
7. Puertollano MA, Algarra I, Ortega E, de Pablo MA and Alvarez de Cienfuegos G: Loss of cell natural killer cell activity after murine tumor transplantation appears as a consequence of dietary lipid administration. Anticancer Res 21: 2697-2702, 2001.
8. Kromann N and Green A: Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974. Acta Med Scand 208: 401-406, 1980.
9. Rose DP and Connolly JM: Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther 83: 217-244, 1999.
10. Bang HO and Dyerberg J: Plasma lipids and lipoproteins in Greenlandic west coast Eskimos. Acta Med Scand 192: 85-94, 1972.
11. Kaizer L, Boyd NF, Kriukow V and Trichler D: Fish consumption and breast cancer risk: an ecological study. Nutr Cancer 12: 61-68, 1989.
12. Paumen MB, Ishida Y, Muramatsu M, Yamamoto M and Honjo T: Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem 272: 3324-3329, 1997.
13. Colquhoun A: Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells. Biochem Mol Biol Int 45: 331-336, 1998.
14. Earnshaw WC, Martins LC and Kaufmann SH: Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68: 383-424, 1999.
15. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
16. Colquhoun A and Schumacher RI: γ-Linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells. Biochim Biophys Acta 1533: 207-219, 2001.
17. Higuchi Y and Yoshimoto T: Arachidonic acid converts the glutathione depletion-induced apoptosis to necrosis by promoting lipid peroxidation and reducing caspase-3 activity in rat glioma cells. Arch Biochem Biophys 400: 133-140, 2002.
18. Gibb RK and Gercel-Taylor C: Use of diphenylamine in the detection of apoptosis. In: Methods in Molecular Medicine (Barlett JMS ed) Totowa, NJ, Humana Press Inc., 2000 pp 679-680.
19. de Pablo MA, Puertollano MA and Alvarez de Cienfuegos G: Biological and clinical significance of lipids as modulators of immune system functions. Clin Diagn Lab Immunol 9: 945-950, 2002.
20. Das UN: Essential fatty acids, lipid peroxidation and apoptosis. Prostaglandins Leukot Essent Fatty Acids 61: 157-163, 1999.
21. Chiu LC, Wan JM and Ooi VE: Induction of apoptosis by dietary polyunsaturated fatty acids in human leukemic cells is not associated with DNA fragmentation. Int J Oncol 17: 789-796, 2000.
22. Greenspan P, Mayer EP and Fowler SD: Nile Red: a selective fluorescent stain for intracellular lipid droplets. J Cell Biol 100: 965-973, 1985.
23. Al-Saffar NMS, Titley JC, Robertson D, Clarke PA, Jackson LE, Leach MO and Ronen SM: Apoptosis is associated with triacylglycerol accumulation in Jurkat T-cells. Br J Cancer 86: 963-970, 2002.
24. Finstad HS, Drevon CA, Kulseth MA, Synstad AV, Knudsen E and Kolset SO: Cell proliferation, apoptosis and accumulation of lipid droplets in U937-1 cells incubated with eicosapentaenoic acid. Biochem J 336: 451-459, 1998.
25. Köhler C, Orrenius S and Zhivotovsky B: Evaluation of caspase activity in apoptotic cells. J Immunol Methods 265: 97-110, 2002.