The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors

Journal of Biological Chemistry

Volumn 281, Issue 27, 2006, Pages 18626-18637

  Van Den Steen, Philippe E ^a   Van Aelst, Ilse ^a   Hvidberg, Vibeke ^b   Piccard, Helene ^a   Fiten, Pierre ^a   Jacobsen, Christian ^b   Moestrup, Soren K ^b   Fry, Simon ^c   Royle, Louise ^c   Wormald, Mark R ^c   Wallis, Russell ^c,d   Rudd, Pauline M ^c   Dwek, Raymond A ^c   Opdenakker, Ghislain ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CATALYSIS; ENZYME INHIBITION; IMMUNOLOGY; SUBSTRATES;

BINDING SITES; CARGO RECEPTORS; ENDOCYTOSIS; LINKER SEQUENCES;

ENZYMES;

AMINO ACID; GELATINASE B; HEMOPEXIN; LECTIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MEGALIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ARTICLE; BIOAVAILABILITY; ENDOCYTOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR MODEL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RECEPTOR BINDING; ULTRACENTRIFUGATION;

BINDING SITES; CATALYTIC DOMAIN; DOWN-REGULATION; GLYCOSYLATION; HEMOPEXIN; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; LDL-RECEPTOR RELATED PROTEIN 2; MATRIX METALLOPROTEINASE 9; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 33745856212     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512308200     Document Type: Article

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