The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII

Journal of Biological Chemistry

Volumn 281, Issue 27, 2006, Pages 18569-18580

  Bukys, Michael A ^a   Orban, Tivadar ^a   Kim, Paul Y ^b   Beck, Daniel O ^a   Nesheim, Michael E ^b   Kalafatis, Michael ^a,c  

^a CLEVELAND STATE UNIVERSITY   (United States)

^b QUEEN S UNIVERSITY   (Canada)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; ENZYME INHIBITION; NEGATIVE IONS; PHYSIOLOGY; SUBSTRATES;

ELECTROPOSITIVE BINDING EXOSITES; PROTEOLYTIC CLEAVAGES; RECOMBINANT PROTHROMBIN MOLECULES; THROMBIN;

ENZYMES;

AMINO ACID; ANION; BETA THROMBIN; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 8; MEIZOTHROMBIN; PROTHROMBIN; THROMBIN;

ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; LIGHT CHAIN; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIONS; BINDING SITES; BLOOD COAGULATION; FACTOR V; FACTOR VIII; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 33745834732     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M600752200     Document Type: Article

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