Central administration of neuropeptide Y induces wakefulness in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 291, Issue 2, 2006, Pages

  Szentirmai, E ^a,b   Krueger, J M ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Electroencephalogram; Fast Fourier transformation; Food intake; Lateral hypothalamus; Slow wave activity

Indexed keywords

NEUROPEPTIDE Y; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROENCEPHALOGRAM; FOOD INTAKE; MALE; MICROINJECTION; MOTOR ACTIVITY; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP; WAKEFULNESS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; ELECTROENCEPHALOGRAPHY; HYPOTHALAMUS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MALE; NEUROPEPTIDE Y; RATS; RATS, SPRAGUE-DAWLEY; SLEEP STAGES; WAKEFULNESS;

EID: 33745828630     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00919.2005     Document Type: Article

References (49)

1. Albers HE and Ferris CF. Neuropeptide Y: role in light-dark cycle entrainment of hamster circadian rhythms. Neurosci Lett 50: 163-168, 1984.
2. Allen YS, Adrian TE, Allen JM, Tatemoto K, Crow TJ, Bloom SR, and Polak JM. Neuropeptide Y distribution in the rat brain. Science 221: 877-879, 1983.
3. Antonijevic IA, Murck H, Bohlhalter S, Frieboes RM, Holsboer F, and Steiger A. Neuropeptide Y promotes sleep and inhibits ACTH and cortisol release in young men. Neuropharmacology 39: 1474-1481, 2000.
4. Backberg M, Hervieu G, Wilson S, and Meister B. Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur J Neurosci 15: 315-328, 2002.
5. Broberger C. Brain regulation of food intake and appetite: molecules and networks. J Intern Med 258: 301-327, 2005.
6. Campbell RE, Smith MS, Allen SE, Grayson BE, Ffrench-Mullen JM, and Grove KL. Orexin neurons express a functional pancreatic polypeptide Y4 receptor. J Neurosci 23: 1487-1497, 2003.
7. Carter DA, Vallejo M, and Lightman SL. Cardiovascular effects of neuropeptide Y in the nucleus tractus solitarius of rats: relationship with noradrenaline and vasopressin. Peptides 6: 421-425, 1985.
8. Dube MG, Kalra SP, and Kalra PS. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res 842: 473-477, 1999.
9. Dube MG, Xu B, Crowley WR, Kalra PS, and Kalra SP. Evidence that neuropeptide Y is a physiological signal for normal food intake. Brain Res 646: 341-344, 1994.
10. Ehlers CL, Reed TK, and Henriksen SJ. Effects of corticotropin-releasing factor and growth hormone-releasing factor on sleep and activity in rats. Neuroendocrinology 42: 467-474, 1986.
11. Ehlers CL, Somes C, Lopez A, Kirby D, and Rivier JE. Electrophysiological actions of neuropeptide Y and its analogs: new measures for anxiolytic therapy? Neuropsychopharmacology 17: 34-43, 1997.
12. Fuxe K, Agnati LF, Harfstrand A, Zini I, Tatemoto K, Pich EM, Hokfelt T, Mutt V, and Terenius L. Central administration of neuropeptide Y induces hypotension bradypnea and EEG synchronization in the rat. Acta Physiol Scand 118: 189-192, 1983.
13. Haas DA and George SR. Neuropeptide Y administration acutely increases hypothalamic corticotropin-releasing factor immunoreactivity: lack of effect in other rat brain regions. Life Sci 41: 2725-2731, 1987.
14. Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, and Upton N. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci USA 96: 10911-10916, 1999.
15. Held K, Antonijevic I, Murck H, Kuenzel H, and Steiger A. Neuropeptide Y (NPY) shortens sleep latency but does not suppress ACTH and cortisol in depressed patients and normal controls. Psychoneuroendocrinology 31: 100-107, 2006.
16. Horvath TL, Diano S, and van den Pol AN. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 19: 1072-1087, 1999.
17. Jain MR, Horvath TL, Kalra PS, and Kalra SP. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regul Pept 87: 19-24, 2000.
18. Jhanwar-Uniyal M, Beck B, Burlet C, and Leibowitz SF. Diurnal rhythm of neuropeptide Y-like immunoreactivity in the suprachiasmatic, arcuate and paraventricular nuclei and other hypothalamic sites. Brain Res 536: 331-334, 1990.
19. Jolicoeur FB, Bouali SM, Fournier A, and St.-Pierre S. Mapping of hypothalamic sites involved in the effects of NPY on body temperature and food intake. Brain Res Bull 36: 125-129, 1995.
20. Kim MS, Rossi M, Abusnana S, Sunter D, Morgan DG, Small CJ, Edwards CM, Heath MM, Stanley SA, Seal LJ, Bhatti JR, Smith DM, Ghatei MA, and Bloom SR. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes 49: 177-182, 2000.
21. Koban M, Le WW, and Hoffman GE. Changes in hypothalamic CRH, NPY, and POMC gene expression during chronic REM sleep deprivation of rats. Endocrinology 147: 421-431, 2005.
22. 2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52: 948-956, 2003.
23. Leibowitz SF, Sladek C, Spencer L, and Tempel D. Neuropeptide Y, epinephrine and norepinephrine in the paraventricular nucleus: stimulation of feeding and the release of corticosterone, vasopressin and glucose. Brain Res Bull 21: 905-912, 1988.
24. Levine AS and Morley JE. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5: 1025-1029, 1984.
25. Li BH, Xu B, Rowland NE, and Kalra SP. c-fos Expression in the rat brain following central administration of neuropeptide Y and effects of food consumption. Brain Res 665: 277-284, 1994.
26. Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, and Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98: 365-376, 1999.
27. Lopez M, Seoane LM, Garcia MC, Dieguez C, and Senaris R. Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus. Neuroendocrinology 75: 34-44, 2002.
28. 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci 19: 1524-1534, 2004.
29. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, and Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 409: 194-198, 2001.
30. Niimi M, Sato M, and Taminato T. Neuropeptide Y in central control of feeding and interactions with orexin and leptin. Endocrine 14: 269-273, 2001.
31. Opp M, Obal F Jr, and Krueger JM. Corticotropin-releasing factor attenuates interleukin 1-induced sleep and fever in rabbits. Am J Physiol Regul Integr Comp Physiol 257: R528-R535, 1989.
32. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates. San Diego, CA: Academic, 2005.
33. Pedrazzini T, Seydoux J, Kunstner P, Aubert JF, Grouzmann E, Beermann F, and Brunner HR. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nat Med 4: 722-726, 1998.
34. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R, and Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380: 243-247, 1996.
35. Rossi M, Kim MS, Morgan DG, Small CJ, Edwards CM, Sunter D, Abusnana S, Goldstone AP, Russell SH, Stanley SA, Smith DM, Yagaloff K, Ghatei MA, and Bloom SR. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139: 4428-4431, 1998.
36. Sakurai T. Roles of orexins in regulation of feeding and wakefulness. Neuroreport 13: 987-995, 2002.
37. Seoane LM, Lopez M, Tovar S, Casanueva FF, Senaris R, and Dieguez C. Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology 144: 544-551, 2003.
38. Stanley BG, Chin AS, and Leibowitz SF. Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action. Brain Res Bull 14: 521-524, 1985.
39. Stanley BG and Leibowitz SF. Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci 35: 2635-2642, 1984.
40. Suda T, Tozawa F, Iwai I, Sato Y, Sumitomo T, Nakano Y, Yamada M, and Demura H. Neuropeptide Y increases the corticotropin-releasing factor messenger ribonucleic acid level in the rat hypothalamus. Brain Res Mol Brain Res 18: 311-315, 1993.
41. Szentirmai E, Hajdu I, Obal F Jr, and Krueger JM. Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Brain Res 1088: 131-140, 2006.
42. Wahlestedt C, Skagerberg G, Ekman R, Heilig M, Sundler F, and Hakanson R. Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Res 417: 33-38, 1987.
43. Willesen MG, Kristensen P, and Romer J. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70: 306-316, 1999.
44. Wolak ML, DeJoseph MR, Cator AD, Mokashi AS, Brownfield MS, and Urban JH. Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry. J Comp Neurol 464: 285-311, 2003.
45. Wren AM, Small CJ, Fribbens CV, Neary NM, Ward HL, Seal LJ, Ghatei MA, and Bloom SR. The hypothalamic mechanisms of the hypophysiotropic action of ghrelin. Neuroendocrinology 76: 316-324, 2002.
46. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, and Bloom SR. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141: 4325-4328, 2000.
47. Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, Matsuzaki I, Miwa Y, Goto K, and Sakurai T. Orexin-induced food intake involves neuropeptide Y pathway. Brain Res 859: 404-409, 2000.
48. Yannielli PC and Harrington ME. Neuropeptide Y in the mammalian circadian system: effects on light-induced circadian responses. Peptides 22: 547-556, 2001.
49. Zini I, Merlo PE, Fuxe K, Lenzi PL, Agnati LF, Harfstrand A, Mutt V, Tatemoto K, and Moscara M. Actions of centrally administered neuropeptide Y on EEG activity in different rat strains and in different phases of their circadian cycle. Acta Physiol Scand 122: 71-77, 1984.