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Volumn 63, Issue 2, 2004, Pages 375-380

The molecular mechanism linking muscle fat accumulation to insulin resistance

Author keywords

Diacylglycerols; Fatty acyl CoA; Insulin resistance; Intramyocellular lipids

Indexed keywords

ACYL COENZYME A; CERAMIDE; DIACYLGLYCEROL; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LIPID; PROTEIN KINASE C; SERINE; THREONINE; TRIACYLGLYCEROL;

EID: 2942735492     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS2004351     Document Type: Conference Paper
Times cited : (81)

References (31)
  • 1
    • 0029066976 scopus 로고
    • Hypoxia stimulates glucose transport in insulin-resistant human skeletal muscle
    • Azevedo JL Jr, Carey JO, Pories WJ, Morris PG & Dohm GL (1995) Hypoxia stimulates glucose transport in insulin-resistant human skeletal muscle. Diabetes 44, 695-698.
    • (1995) Diabetes , vol.44 , pp. 695-698
    • Azevedo Jr., J.L.1    Carey, J.O.2    Pories, W.J.3    Morris, P.G.4    Dohm, G.L.5
  • 3
    • 0030792250 scopus 로고    scopus 로고
    • Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor
    • Bossenmaier B, Mosthaf L, Mischak H, Ullrich A & Haring HU (1997) Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor. Diabetologia 40, 863-866.
    • (1997) Diabetologia , vol.40 , pp. 863-866
    • Bossenmaier, B.1    Mosthaf, L.2    Mischak, H.3    Ullrich, A.4    Haring, H.U.5
  • 10
    • 0027392973 scopus 로고
    • Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats
    • Dolan PL, Tapscott EB, Dorton PJ & Dohm GL (1993) Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats. Biochemical Journal 289, 423-426.
    • (1993) Biochemical Journal , vol.289 , pp. 423-426
    • Dolan, P.L.1    Tapscott, E.B.2    Dorton, P.J.3    Dohm, G.L.4
  • 12
    • 0028903232 scopus 로고
    • Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
    • Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ & Dohm GL (1995) Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. Journal of Clinical Investigation 95, 2195-2204.
    • (1995) Journal of Clinical Investigation , vol.95 , pp. 2195-2204
    • Goodyear, L.J.1    Giorgino, F.2    Sherman, L.A.3    Carey, J.4    Smith, R.J.5    Dohm, G.L.6
  • 15
    • 0025173789 scopus 로고
    • Effects of insulin on diacylglycerol-protein kinase C signaling in rat diaphragm and soleus muscles and relationship to glucose transport
    • Ishizuka T, Cooper DR, Hernandez H, Buckley D, Standaert M & Farese RV (1990) Effects of insulin on diacylglycerol-protein kinase C signaling in rat diaphragm and soleus muscles and relationship to glucose transport. Diabetes 39, 181-190.
    • (1990) Diabetes , vol.39 , pp. 181-190
    • Ishizuka, T.1    Cooper, D.R.2    Hernandez, H.3    Buckley, D.4    Standaert, M.5    Farese, R.V.6
  • 16
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani SI, Ruderman NB, Schmieder F & Boden G (2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51, 2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 17
    • 0033861608 scopus 로고    scopus 로고
    • Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity
    • Itani SI, Zhou Q, Pories WJ, MacDonald KG & Dohm GL (2000) Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes 49, 1353-1358.
    • (2000) Diabetes , vol.49 , pp. 1353-1358
    • Itani, S.I.1    Zhou, Q.2    Pories, W.J.3    MacDonald, K.G.4    Dohm, G.L.5
  • 19
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley DE, Goodpaster BH, Wing RR & Simoneau JA (1999) Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. American Journal of Physiology 277, E1130-E1141.
    • (1999) American Journal of Physiology , vol.277
    • Kelley, D.E.1    Goodpaster, B.H.2    Wing, R.R.3    Simoneau, J.A.4
  • 20
    • 0027946529 scopus 로고
    • Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus
    • Kelley DE & Simoneau JA (1994) Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation 94, 2349-2356.
    • (1994) Journal of Clinical Investigation , vol.94 , pp. 2349-2356
    • Kelley, D.E.1    Simoneau, J.A.2
  • 22
    • 0019332349 scopus 로고
    • Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover
    • Kishimoto A, Takai Y, Mori T, Kikkawa U & Nishizuka Y (1980) Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. Journal of Biological Chemistry 255, 2273-2276.
    • (1980) Journal of Biological Chemistry , vol.255 , pp. 2273-2276
    • Kishimoto, A.1    Takai, Y.2    Mori, T.3    Kikkawa, U.4    Nishizuka, Y.5
  • 23
    • 0029853098 scopus 로고    scopus 로고
    • Lipid mediators of insulin resistance: Ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes
    • Long SD & Pekala PH (1996) Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes. Biochemical Journal 319, 179-184.
    • (1996) Biochemical Journal , vol.319 , pp. 179-184
    • Long, S.D.1    Pekala, P.H.2
  • 24
    • 0036092239 scopus 로고    scopus 로고
    • Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD (2002) Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51, 7-18.
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 25
    • 0033632040 scopus 로고    scopus 로고
    • Lipoprotein subpopulation distributions in lean, obese, and type 2 diabetic women: A comparison of African and white Americans
    • MacLean PS, Bower JF, Vadlamudi S, Green T & Barakat HA (2000) Lipoprotein subpopulation distributions in lean, obese, and type 2 diabetic women: a comparison of African and white Americans. Obesity Research 8, 62-70.
    • (2000) Obesity Research , vol.8 , pp. 62-70
    • MacLean, P.S.1    Bower, J.F.2    Vadlamudi, S.3    Green, T.4    Barakat, H.A.5
  • 26
    • 0021137833 scopus 로고
    • Turnover of inositol phospholipids and signal transduction
    • Nishizuka Y (1984) Turnover of inositol phospholipids and signal transduction. Science 225, 1365-1370.
    • (1984) Science , vol.225 , pp. 1365-1370
    • Nishizuka, Y.1
  • 27
    • 0030784947 scopus 로고    scopus 로고
    • Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA
    • Oakes ND, Bell KS, Furler SM, Camilleri S, Saha AK, Ruderman NB, Chisholm DJ & Kraegen EW (1997) Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes 46, 2022-2028.
    • (1997) Diabetes , vol.46 , pp. 2022-2028
    • Oakes, N.D.1    Bell, K.S.2    Furler, S.M.3    Camilleri, S.4    Saha, A.K.5    Ruderman, N.B.6    Chisholm, D.J.7    Kraegen, E.W.8
  • 28
    • 0036295566 scopus 로고    scopus 로고
    • Protein kinase C and lipid-induced insulin resistance in skeletal muscle
    • Schmitz-Peiffer C (2002) Protein kinase C and lipid-induced insulin resistance in skeletal muscle. Annals of the New York Academy of Sciences 967, 146-157.
    • (2002) Annals of the New York Academy of Sciences , vol.967 , pp. 146-157
    • Schmitz-Peiffer, C.1
  • 29
    • 0021992422 scopus 로고
    • Long-chain fatty acyl-coenzyme As activate both the ligand-binding and protein kinase activities of phorboid and ingenoid receptor
    • Shoyab M (1985) Long-chain fatty acyl-coenzyme As activate both the ligand-binding and protein kinase activities of phorboid and ingenoid receptor. Archives of Biochemistry and Biophysics 236, 435-440.
    • (1985) Archives of Biochemistry and Biophysics , vol.236 , pp. 435-440
    • Shoyab, M.1
  • 30
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI (2000) Cellular mechanisms of insulin resistance. Journal of Clinical Investigation 106, 171-176.
    • (2000) Journal of Clinical Investigation , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 31
    • 0033056557 scopus 로고    scopus 로고
    • Dephosphorylation increases insulin-stimulated receptor kinase activity in skeletal muscle of obese Zucker rats
    • Zhou Q, Dolan PL & Dohm GL (1999) Dephosphorylation increases insulin-stimulated receptor kinase activity in skeletal muscle of obese Zucker rats. Molecular and Cellular Biochemistry 194, 209-216.
    • (1999) Molecular and Cellular Biochemistry , vol.194 , pp. 209-216
    • Zhou, Q.1    Dolan, P.L.2    Dohm, G.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.