Radiation-induced lysosomal iron reactivity: Implications for radioprotective therapy

IUBMB Life

Volumn 58, Issue 7, 2006, Pages 395-401

  Persson, H ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; Autophagocytosis; Ionizing radiation; Iron chelator; Lipoic acid; Lysosome; WR 1065

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; DEFEROXAMINE; HYDROXYL RADICAL; IRON CHELATING AGENT; METALLOPROTEIN;

APOPTOSIS; AUTOPHAGY; CELL COMPARTMENTALIZATION; CELL DEATH; DNA DAMAGE; FENTON REACTION; HUMAN; HUMAN CELL; IONIZING RADIATION; IRON METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN DEGRADATION; RADIATION INJURY; RADIATION PROTECTION; RADIOLYSIS; REVIEW; TARGET CELL;

IRON; LYSOSOMES; OXIDATIVE STRESS; RADIATION-PROTECTIVE AGENTS;

EID: 33745712367     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540600755998     Document Type: Review

References (36)

1. Blommart, E. F., Luiken, J. J., and Meijer, A. J. (1997) Autophagic proteolysis: control and specificity. Histochem. J. 29, 365-385.
2. Cuervo, A. M. (2004) Autophagy: in sickness and in health. Trends Cell Biol. 14, 70-77.
3. Ahlberg, J., Marzella, L., and Glaumann, H. (1982) Uptake and degradation of proteins by isolated rat liver lysosomes. Suggestion of a microautophagic pathway of proteolysis. Lab. Invest. 47, 523-532.
4. Zdolsek, J. M., Roberg, K., and Brunk, U. T. (1993) Visualization of iron in cultured macrophages: a cytochemical light and electron microscopic study using autometallography. Free Radic. Biol. Med. 15, 1-11.
5. Radisky, D. C., and Kaplan, J. (1998) Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts. Biochem. J. 336, 201-205.
6. Persson, H. L., Nilsson, K. J., and Brunk, U. T. (2001) Novel cellular defenses against iron and oxidation: ferritin and autophagocytosis preserve lysosomal stability in airway epithelium. Redox Rep. 6, 57-63.
7. Yu, Z., Persson, H. L., Eaton, J. W., and Brunk, U. T. (2003) Intralysosomal iron: a major determinant of oxidant-induced cell death. Free Radic. Biol. Med. 34, 1243-1252.
8. Petrat, F., de Groot, H., and Rauen, U. (2001) Subcellular distribution of chelatable iron: a laser scanning microscopic study in isolated hepatocytes and liver endothelial cells. Biochem. J. 356, 61-69.
9. Persson, H. L., and Richardson, D. R. (2005) Iron-binding drugs targeted to lysosomes : a potential strategy to treat inflammatory lung disorders. Expert Opin. Investig. Drugs 14, 997-1008.
10. Brunk, U. T., Neuzil, J., and Eaton, J. W. (2001) Lysosomal involvement in apoptosis. Redox Rep. 6, 91-97.
11. Chwieralski, C. E., Welte, T. and Bühling, F. (2006) Cathepsin-regulated apoptosis. Apoptosis 11, 143-149.
12. Kruszewski, M. (2003) Labile iron pool: the main determinant of cellular response to oxidative stress. Mutation Res. 531, 81-92.
13. Persson, H. L. (2005) Iron-dependent lysosomal destabilization initiates silica-induced apoptosis in murine macrophages. Toxicol. Lett. 159, 124-133.
14. Persson, H. L., Kurz, T., Eaton, J. W., and Brunk, U. T. (2005) Radiation-induced cell death: importance of lysosomal destabilization. Biochem. J. 389, 877-884.
15. Kurz, T., Leake, A., von Zglinicki, T., and Brunk, U. T. (2004) Relocalized redox-active lysosomal iron is an important mediator of oxidative stress-induced DNA damage. Biochem. J. 378, 1039-1045.
16. Tenopoulou, M., Doulias, P. T., Barbouti, A., Brunk, U., and Galaris, D. (2005) The role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis. Biochem. J. 387, 703-710.
17. Ollinger, K., and Roberg, K. (1997) Nutrient deprivation of cultured rat hepatocytes increases the desferrioxamine-available iron pool and augments the sensitivity to hydrogen peroxide. J. Biol. Chem. 272, 23707-23711.
18. Itoh, K., Ishii, T., Wakabayashi, N., and Yamamoto, M. (1999) Regulatory mechanisms of cellular response to oxidative stress. Free Radic. Res. 31, 319-324.
19. Baird, S. K., Kurz, T., and Brunk, U. T. (2006) Metallothionein protects against oxidative stress-induced lysosomal destabilization. Biochem. J. 15, 275-283.
20. Graf, E., Mahoney, J. R., Bryant, R. G., and Eaton, J. W. (1984) Iron-catalyzed hydroxyl radical formation: stringent requirement for free iron-coordination site. J. Biol. Chem. 259, 3620-3624.
21. Lloyd, J. B., Cable, H. and Rice-Evans, C. (1991) Evidence that desferrioxamine cannot enter cells by passive diffusion. Biochem. Pharmacol. 41, 1361-1363.
22. de Duve, C., de Barsy, T., Poole, B., Trouet, A., Tulkens, P., and van Hoof, F. (1974) Commentary: Lysosomotropic agents. Biochem. Pharmacol. 23, 2495-2531.
23. Persson, H. L., Svensson, A. I., and Brunk, U. T. (2001) Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. Redox Rep. 6, 327-334.
24. Persson, H. L., Yu, Z., Tirosh, O., Eaton, J. W., and Brunk, U. T. (2003) Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic. Biol. Med. 34, 1295-1305.
25. Yu, Z., Eaton, J. W., and Persson, H. L. (2003) The radioprotective agent, amifostine, suppresses the reactivity of intralysosomal iron. Redox Rep. 8, 347-355.
26. Scherer, E., Streffer, C., and Trott, K. R. (1991) Radiopathology of Organs and Tissues. Springer-Verlag, New York, 1-404.
27. Ogawa, Y., Takahashi, T., Kobayashi, T., Toda, M., Nishioka, A., Kariya, S., Seguchi, H., Yamamoto, H., and Yoshida, S. (2003) Comparison of radiation-induced reactive oxygen species formation in adult articular chondrocytes and that in human peripheral T cells: possible implication in radiosensitivity. Int. J. Mol. Med. 11, 455-459.
28. Ogawa, Y., Kobayashi, T., Nishioka, A., Kariya, S., Ohnishi, T., Hamasato, S., Seguchi, H., and Yoshida, S. (2004) Reactive oxygen species-producing site in radiation-induced apoptosis of human peripheral T cells: involvement of lysosomal membrane destabilization. Int. J. Mol. Med. 13, 69-73.
29. Ogawa, Y., Kobayashi, T., Nishioka, A., Kariya, S., Ohnishi, T., Hamasato, S., Seguchi, H., and Yoshida, S. (2004) Reactive oxygen species-producing site in radiation and hydrogen peroxide-induced apoptosis of human peripheral T cells: involvement of lysosomal membrane destabilization. Int. J. Mol. Med. 13, 655-660.
30. Nakagami, Y., Ito, M., Hara, T., Inoue, T., and Matsubara, S. (2003) Nuclear translocation of DNaseII and acid phosphatase during radiation-induced apoptosis in HL60 cells. Acta Oncol. 42, 227-236.
31. Zhao, H., Cai, Y., Santi, S., Lafrenie, R., and Lee, H. (2005) Chloroquine-mediated radiosensitization is due to the destabilization of the lysosomal membrane and subsequent induction of cell death by necrosis. Radiat. Res. 164, 250-257.
32. Paglin, S., Hollister, T., Delohery, T., Hackett, N., McMahill, M., Sphicas, E., Domingo, D., and Yahalom, J. (2001) A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res. 61, 439-444.
33. Gozuacik, D., and Kimchi, A. (2004) Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23, 2891-2906.
34. Daido, S., Yamamoto, A., Fujiwara, K., Sawaya, R., Kondo, S., and Kondo, Y. (2005) Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignt glioma cells by inducing autophagy. Cancer Res. 65, 4368-4375.
35. Kagedal, K., Zhao, M., Svensson, I., and Brunk, U. T. (2001) Spingosine-induced apoptosis is dependent on lysosomal proteases. Biochem. J. 359, 335-343.
36. 2-induced apoptosis of alveolar type II cells. J. Cell Biochem. 94, 433-445.