Cardiovascular expression of the Mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay

American Journal of Pathology

Volumn 169, Issue 1, 2006, Pages 105-118

  Delaloy, Céline ^a,b,c   Hadchouel, Juliette ^a,b   Imbert Teboul, Martine ^d   Clemessy, Maud ^a,b   Houot, Anne Marie ^a,b   Jeunemaitre, Xavier ^a,b,e  

^a INSERM   (France)

^b l'alimentation et l'Environnement   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d CNRS   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DNA FRAGMENT; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; EMBRYO; ESCHERICHIA COLI; EXON; GENE; GENE CASSETTE; GENE EXPRESSION; GENE TARGETING; HYPERTENSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY; TRANSGENE; WNK1 GENE;

EID: 33745700719     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2006.051290     Document Type: Article

References (42)

1. Wilson F, Disse-Nicodème S, Choate K, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford D, Lipkin G, Achard J-M, Feely M, Dussol B, Berland Y, Unwin R, Simon D, Farfel Z, Jeunemaitre X, Litton R: Mutations in WNK kinases reveal a novel mechanism of human hypertension. Science 2001, 293:1107-1112
2. Hadchouel J, Delaloy C, Faure S, Achard JM, Jeunemaitre X: Familial hyperkalemic hypertension. J Am Soc Nephrol 2006, 98:421-428
3. Yamauchi K, Rai T, Kobayashi K, Sohara E, Suzuki T, Itoh T, Suda S, Hayama A, Sasaki S, Uchida S: Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci USA 2004, 101:4690-4694
4. Kahle KT, Wilson FH, Lalioti M, Toka H, Qin H, Lifton RP: WNK kinases: molecular regulators of integrated epithelial ion transport. Curr Opin Nephrol Hypertens 2004, 13:557-562
5. Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP: Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 2003, 100:680-684
6. Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH: WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem 2000, 275:16795-16801
7. Delaloy C, Lu J, Houot AM, Disse-Nicodeme S, Gasc JM, Corvol P, Jeunemaitre X: Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-detective isotorm. Mol Cell Biol 2003, 23:9208-9221
8. Kahle KT, Wilson FH, Lifton RP: Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch. Trends Endocrinol Metab 2005, 16:98-103
9. Subramanya AR, Yang CL, Zhu X, Ellison DH: Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Am J Physiol Renal Physiol 2006, 290:F619-F624
10. Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH: WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci USA 2005, 102:10315-10320
11. Naray-Fejes-Toth A, Snyder PM, Fejes-Toth G: The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport. Proc Natl Acad Sci USA 2004, 101:17434-17439
12. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP: Human hypertension caused by mutations in WNK kinases. Science 2001, 293:1107-1112
13. Verissimo F, Jordan P: WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. Oncogene 2001, 20:5562-5569
14. O'Reilly M, Marshall E, Speirs HJ, Brown RW: WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol 2003, 14:2447-2456
15. Choate KA, Kahle KT, Wilson FH, Nelson-Williams C, Lifton RP: WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl-transporting epithelia. Proc Natl Acad Sci USA 2003, 100:663-668
16. Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key Jr BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci USA 2003, 100:14109-14114
17. Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, Court DL, Jenkins NA, Copeland NG: A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 2001, 73:56-65
18. Liu P, Jenkins NA, Copeland NG: A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 2003, 13:476-484
19. Hogan B, Beddington R, Costantini F, Lacy E: Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor, Cold Spring Harbor Laboratory Press, 1994
20. Nijenhuis T, Hoenderop JG, Loffing J, van der Kemp AW, van Os CH, Bindels RJ: Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney. Kidney Int 2003, 64:555-564
21. Kim GH, Ecelbarger CA, Mitchell C, Packer RK, Wade JB, Knepper MA: Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop. Am J Physiol 1999, 276:F96-F103
22. Loffing J, Pietri L, Aregger F, Bloch-Faure M, Ziegler U, Meneton P, Rossier BC, Kaissling B: Differential subcellular localization of ENaC subunits in mouse kidney in response to high- and low-Na diets. Am J Physiol 2000, 279:F252-F258
23. Eichmann A, Yuan L, Breant C, Alitalo K, Koskinen PJ: Developmental expression of pim kinases suggests functions also outside of the hematopoietic system. Oncogene 2000, 19:1215-1224
24. Etchevers HC, Vincent C, Le Douarin NM, Couly GF: The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain. Development 2001, 128:1059-1068
25. Virlon B, Cheval L, Buhler JM, Billon E, Doucet A, Elalouf JM: Serial microanalysis of renal transcriptomes. Proc Natl Acad Sci USA 1999, 96:15286-15291
26. Nissant A, Lourdel S, Baillet S, Paulais M, Marvao P, Teulon J, Imbert-Teboul M: Heterogeneous distribution of chloride channels along the distal convoluted tubule probed by single-cell RT-PCR and patch clamp. Am J Physiol 2004, 287:F1233-F1243
27. Benedito R, Duarte A: Expression of DII4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr Patterns 2005, 5:750-755
28. Harvey RP: Patterning the vertebrate heart. Nat Rev Genet 2002, 3:544-556
29. Xu Q, Modrek B, Lee C: Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. Nucleic Acids Res 2002, 30:3754-3766
30. Conway SJ, Kruzynska-Frejtag A, Kneer PL, Machnicki M, Koushik SV: What cardiovascular defect does my prenatal mouse mutant have, and why? Genesis 2003, 35:1-21
31. Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH: WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem 2004, 279:7826-7831
32. Hayashi M, Lee JD: Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice. J Mol Med 2004, 82:800-808
33. Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH: WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Mol Cell 2004, 15:741-751
34. Chapman ER: Synaptotagmin: a Ca(2+) sensor that triggers exocytosis? Nat Rev Mol Cell Biol 2002, 3:498-508
35. Berton F, Iborra C, Boudier JA, Seagar MJ, Marqueze B: Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS. J Neurosci 1997, 17:1206-1216
36. Huang CM, Miyamoto H, Huang RH: The mouse cerebellum from 1 to 34 months: parallel fibers. Neurobiol Aging 2005, [Epub ahead of Print]
37. Roitman AV, Pasalar S, Johnson MT, Ebner TJ: Position, direction of movement, and speed tuning of cerebellar Purkinje cells during circular manual tracking in monkey. J Neurosci 2005, 25:9244-9257
38. Yang CL, Angell J, Mitchell R, Ellison DH: WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 2003, 111:1039-1045
39. Yang CL, Zhu X, Wang Z, Subramanya AR, Ellison DH: Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J Clin Invest 2005, 115:1379-1387
40. Lazrak A, Liu Z, Huang CL: Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci USA 2006, 103:1615-1620
41. Kato Y, Sasaki H: Imprinting and looping: epigenetic marks control interactions between regulatory elements. Bioessays 2005, 27:1-4
42. Schumacher A, Koetsier PA, Hertz J, Doerfler W: Epigenetic and genotype-specific effects on the stability of de novo imposed methylation patterns in transgenic mice. J Biol Chem 2000, 275:37915-37921