Density functional studies on herpes simplex virus type 1 thymidine kinase-substrate interactions: The role of Tyr-172 and Met-128 in thymine fixation

Proteins: Structure, Function and Genetics

Volumn 31, Issue 4, 1998, Pages 453-459

  Alber, F ^a   Kuonen, O ^a   Scapozza, L ^a   Folkers, G ^a   Carloni, P ^b,c  

^a ETH ZURICH   (Switzerland)

^b IBM RESEARCH ZURICH   (Switzerland)

^c SISSA   (Italy)

Author keywords

Functional role of amino acids; Mutants; Quantum mechanical calculations; Substrate enzyme interactions

Indexed keywords

THYMIDINE KINASE;

AMINO ACID SEQUENCE; ARTICLE; DNA METABOLISM; ENZYME SUBSTRATE COMPLEX; HERPES SIMPLEX VIRUS 1; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; VIRUS DNA CELL DNA INTERACTION;

ADENOSINE TRIPHOSPHATE; BINDING SITES; COMPUTER SIMULATION; ELECTROSTATICS; HYDROGEN BONDING; METHIONINE; MODELS, MOLECULAR; SIMPLEXVIRUS; THYMIDINE; THYMIDINE KINASE; TYROSINE; VIRAL PROTEINS;

HERPES; HUMAN HERPESVIRUS 1;

EID: 0032100630     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19980601)31:4<453::AID-PROT11>3.0.CO;2-E     Document Type: Article

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