Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells

Biological Chemistry

Volumn 387, Issue 6, 2006, Pages 807-811

  Prezas, Panagiotis ^a,b   Arlt, Matthias J E ^a   Viktorov, Petar ^a   Soosaipillai, Antoninus ^c   Holzscheiter, Leon ^a   Schmitt, Manfred ^a   Talieri, Maroulio ^b   Diamandis, Eleftherios P ^c   Krüger, Achim ^a   Magdolen, Viktor ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b SAINT SAVVAS HOSPITAL   (Greece)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Nude mice; Ovarian cancer; Serine protease; Tumor invasion

Indexed keywords

KALLIKREIN; SERINE PROTEINASE;

CANCER CELL; CANCER INVASION; CELL PROLIFERATION; CONFERENCE PAPER; GENE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; KLK4 GENE; KLK5 GENE; KLK6 GENE; KLK7 GENE; MALIGNANT NEOPLASTIC DISEASE; MULTIGENE FAMILY; NUDE MOUSE; OVARY CANCER; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KALLIKREINS; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASMS, EXPERIMENTAL; OVARIAN NEOPLASMS; TISSUE KALLIKREINS; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN;

MUS MUSCULUS;

EID: 33745653318     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2006.102     Document Type: Conference Paper

References (39)

1. Balk, S.P., Ko, Y.-J., and Bubley, G.J. (2003). Biology of prostate-specific antigen. J. Clin. Oncol. 21, 383-391.
2. Bayes, A., Tsetsenis, T., Ventura, S., Vendrell, J., Aviles, F.X., and Sotiropoulou, G. (2004). Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation. Biol. Chem. 385, 517-524.
3. Bhoola, K., Ramsaroop, R., Plendl, J., Cassim, B., Dlamini, Z., and Naicker, S. (2001). Kallikrein and kinin receptor expression in inflammation and cancer. Biol. Chem. 382, 77-89.
4. Borgono, C.A. and Diamandis, E.P. (2004). The emerging roles of human kallikreins in cancer. Nat. Rev. Cancer 4, 876-890.
5. Brattsand, M., Stefansson, K., Lundh, C., Haasum, Y., and Egelrud, T. (2005). A proteolytic cascade of kallikreins in the stratum corneum. J. Invest. Dermatol. 124, 198-203.
6. Caubet, C., Jonca, N., Brattsand, M., Guerrin, M., Bernard, D., Schmidt, R., Egelrud, T., Simon, M., and Serre, G. (2004). Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J. Invest. Dermatol. 122, 1235-1244.
7. Clements, J.A., Willemsen, N.M., Myers, S.A., and Dong, Y. (2004). The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers. Crit. Rev. Clin. Lab. Sci. 41, 265-312.
8. Diamandis, E.P., Yousef, G.M., Soosaipillai, A.R., and Bunting, P. (2000). Human kallikrein 6 (zyme/protease M/neurosin): a new serum biomarker of ovarian carcinoma. Clin. Biochem. 33, 579-583.
9. Diamandis, E.P., Scorilas, A., Fracchioli, S., Van Gramberen, M., de Bruijn, H., Henrik, A., Soosaipillai, A., Grass, L., Yousef, G.M., Stenman, U.H., et al. (2003). Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma. J. Clin. Oncol. 21, 1035-1043.
10. Deperthes, D., Frenette, G., Brillard-Bourdet, M., Bourgeois, L., Gauthier, F., Tremblay, R.R., and Dube, J.Y. (1996). Potential involvement of kallikrein hK2 in the hydrolysis of the human seminal vesicle proteins after ejaculation. J. Androl. 17, 659-665.
11. Dhar, S., Bhargava, R., Yunes, M., Li, B., Goyal, J., Naber, S.P., Wazer, D.F., and Band, V. (2001). Analysis of normal epithelial cell specific-1 (NES1)/-kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer. Clin. Cancer Res. 7, 3393-3398.
12. Dong, Y., Kaushal, A., Bui, L., Chu, S., Fuller, P.J., Nicklin, J., Samaratunga, H., and Clements, J.A. (2001). Human kallikrein 4 (KLK4) is highly expressed in serous ovarian carcinomas. Clin. Cancer Res. 7, 2363-2371.
13. Dong, Y., Kauschal, A., Brattsand, M., Nicklin, J., and Clements, J.A. (2003). Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. Clin. Cancer Res. 9, 1710-1720.
14. Fischer, K., Lutz, V., Wilhelm, O., Schmitt, M., Graeff, H., Heiss, P., Nishiguchi, T., Harbeck, N., Kessler, H., Luther, T., et al. (1998). Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function. FEBS Lett. 438, 101-105.
15. Hoffman, B.R., Katsaros, D., Scorilas, A., Diamandis, P., Fracchioli, S., Rigault de la Longrais, I.A., Colgan, T., Puopolo, M., Giardina, G., Massobrio, M., and Diamandis, E.P. (2002). Immuno-fluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker. Br. J. Cancer 87, 763-771.
16. Kim, H., Scorilas, A., Katsaros, D., Yousef, G.M., Massobrio, M., Fracchioli, S., Piccinno, R., Gordini, G., and Diamandis, E.P. (2001). Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer. Br. J. Cancer 84, 643-650.
17. Kishi, T., Soosaipillai, A., Grass, L., Little, S.P., Johnstone, E.M., and Diamandis, E.P. (2004). Development of an immunofluorometric assay and quantification of human kallikrein 7 in tissue extracts and biological fluids. Clin. Chem. 50, 709-716.
18. Krol, J., Kopitz, C., Kirschenhofer, A., Schmitt, M., Magdolen, U., Krüger, A., and Magdolen, V. (2003). Inhibition of intraperitoneal tumor growth of human ovarian cancer cells by bi- and tri-functional inhibitors of tumor-associated proteolytic systems. Biol. Chem. 384, 1097-1102.
19. Kyriakopoulou, L., Yousef, G.M., Scorilas, A., Katsaros, D., Massobrio, M., Fracchioli, S., and Diamandis, E. (2003). Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer. Clin. Biochem. 36, 135-143.
20. Nagahara, H., Mimori, K., Utsunomiya, T., Barnard, G.F., Ohir, M., Hirakawa, K., Mori, M. (2005). Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer. Clin. Cancer Res. 11, 6800-6806.
21. Obiezu, C.V. and Diamandis, E.P. (2005). Human tissue kallikrein gene family: applications in cancer. Cancer Lett. 224, 1-22.
22. Obiezu, C.V., Scorilas, A., Katsaros, D., Massobrio, M., Yousef, G.M., Fracchioli, S., Rigault de la Longrais, I.A., Arisio, R., and Diamandis, E.P. (2001). Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients, Clin. Cancer Res. 7, 2380-2386.
23. Obiezu, C.V., Shan, S.J., Soosaipillai, A., Luo, L.Y., Grass, L., Sotiropoulou, G., Petraki, C.D., Papanastasiou, P.A., Levesque, M.A., and Diamandis, E.P. (2005). Human kallikrein 4: quantitative study in tissues and evidence for its secretion into biological fluids. Clin. Chem. 51, 1432-1442.
24. Ogawa, K., Utsunomiya, T., Mimori, K., Tanaka, F., Inoue, H., Nagahara, H., Murayama, S., and Mori, M. (2005) Clinical significance of human kallikrein gene 6 messenger RNA expression in colorectal cancer. Clin. Cancer Res. 11, 2889-2893.
25. Parmar, M.K., Ledermann, J.A., Colombo, N., du Bois, A., Delaloye, J.F., Kristensen, G.B., Wheeler, S., Swart, A.M., Qian, W., Torri, V., Floriani, I., Jayson, G., Lamont, A., Trope, C., ICON and AGO Collaborators (2003). Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. Lancet 361, 2099-2106.
26. Santin, A.D., Diamandis, E.P., Bellone, S., Soosaipillai, A., Cane, S., Palmieri, M., Burnett, A., Roman, J.J., and Pecorelli, S. (2005). Human kallikrein 6: a new potential serum biomarker for uterine serous papillary cancer. Clin. Cancer Res. 11, 3320-3325.
27. Simon, M., Jonca, N., Guerrin, M., Haftek, M., Bernard, D., Caubet, C., Egelrud, T., Schmidt, R., and Serre, G. (2001). Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation. J. Biol. Chem. 276, 20292-20299.
28. Schultz, R.M. and Liebman, M.N. (1997). Structure-function relationship in protein families. In: Textbook of Biochemistry with Clinical Correlations, 4th edition, T.M. Devlin, ed. (New York, USA: Wiley-Liss), Vol. 116, pp. 1-2.
29. Silverthorn, D.U. (1995). Human Physiology: An Integrated Approach (Upper Saddle River, NJ, USA: Prentice-Hall).
30. Takayama, T.K., Fujikawa, K., and Davie, E.W. (1997). Characterization of the precursor of prostate-specific antigen. Activation by trypsin and by human glandular kallikrein. J. Biol. Chem. 272, 21582-21588.
31. Tanimoto, H., Underwood, L.J., Shigemasa, K., Yan Yan, M.S., Clarke, J., Parmley, T.H., and O'Brien, T.J. (1999). The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells. Cancer 86, 2074-2082.
32. Tanimoto, H., Underwood, L.J., Shigemasa, K., Parmley, T.H., and O'Brien, T.J. (2001). Increased expression of protease M in ovarian tumors. Tumour Biol. 22, 11-18.
33. Valdes, G., Germain, A.M., Corthorn, J., Chacon, C., Figueroa, C.D., and Muller-Esterl, W. (2001). Tissue kallikrein and bradykinin B2 receptor in human uterus in luteal phase and in early and late gestation. Endocrine 16, 207-215.
34. Yousef, G.M. and Diamandis, E.P. (2001). The new human tissue kallikrein family: structure, function and association to disease. Endocr. Rev. 22, 184-204.
35. Yousef, G.M. and Diamandis, E.P. (2002). Human tissue kallikreins: a new enzymatic cascade pathway? Biol. Chem. 383, 1045-1057.
36. Yousef, G.M., Scorilas, A., Chang, A., Rendl, L., Diamandis, M., Jung, K., and Diamandis, E.P. (2002). Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues. Prostate 51, 126-132.
37. Yousef, G.M., Polymeris, M.E., Yacoub, G.M., Scorilas, A., Soosaipillai, A., Popalis, S., Fracchioli, S., Katsaros, D., and Diamandis, E.P. (2003a). Parallel overexpression of seven kallikrein genes in ovarian cancer. Cancer Res. 63, 2223-2227.
38. Yousef, G.M., Polymeris, M.E., Grass, L., Soosaipillai, A., Chan, P.C., Scorilas, A., Borgono, C., Harbeck, N., Schmalfeldt, B., Dorn, J., et al. (2003b). Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer. Cancer Res. 63, 3958-3965.
39. Yousef, G.M., Yacoub, G.M., Polymeris, M.E., Popalis, C., Soosaipillai, A., and Diamandis, E.P. (2004). Kallikrein gene down-regulation in breast cancer. Br. J. Cancer 90, 167-172.