Determinants of fasting total serum homocysteine levels in liver transplant recipients

Experimental and Clinical Transplantation

Volumn 4, Issue 1, 2006, Pages 462-466

  Akoglu, Bora ^a   Wondra, Kathrin ^a   Caspary, Wolfgang F ^a   Faust, Dominik ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Folate; Homocysteine; Immunosuppressive drugs; Liver transplantation; Obesity

Indexed keywords

CYCLOSPORIN; FOLIC ACID; HOMOCYSTEINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BODY MASS; CLINICAL PROTOCOL; CORRELATION ANALYSIS; DIET RESTRICTION; DISEASE ACTIVITY; FEMALE; GRAFT RECIPIENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERHOMOCYSTEINEMIA; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FUNCTION; LIVER DISEASE; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; OBESITY; RISK FACTOR;

ADULT; AGED; FASTING; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; RISK FACTORS;

EID: 33745619768     PISSN: 13040855     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Miller JW, Nadeau MR, Smith J, Smith D, Selhub J. Folate-deficiency-induced homocystinemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism. Biochem J 1994; 298 (Pt 2): 415-419
2. Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ. Homocysteine, B Vitamin status, and cognitive function in the elderly. Am J Clin Nutr 2002; 75: 908-913
3. Fassbender K, Mielke O, Bertsch T, Nafe B, Froschen S, Hennerici M. Homocysteine in cerebral macroangiography and microangiopathy. Lancet 1999; 353: 1586-1587
4. Schachinger V, Britten MB, Elsner M, Walter DH, Scharrer I, Zeiher AM. A positive family history of premature coronary artery disease is associated with impaired endothelium-dependent coronary blood flow regulation. Circulation 1999; 100: 1502-1508
5. Wu LL, Wu JT. Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta 2002; 322: 21-28
6. Akoglu B, Milovic V, Caspary WF, Faust D. Hyperproliferation of homocysteine-treated colon cancer cells is reversed by folate and 5-methyltetrahydrofolate. Eur J Nutr 2004; 43(2): 93-99
7. Mason JB. Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism. J Nutr 2003; 133: 941S-947S
8. Cravo M, Fidalgo P, Pereira AD, Gouveia-Oliveira A, Chaves P, Selhub J, et al. DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. Eur J Cancer Prev 1994; 3: 473-479
9. Friedman AN, Rosenberg IH, Selhub J, Levey AS, Bostom AG. Hyperhomocysteinemia in renal transplant recipients. Am J Transplant 2002; 2: 308-313
10. Johnston SD, Morris JK, Cramb R, Gunson BK, Neuberger J. Cardiovascular morbidity and mortality after orthotopic liver transplantation. Transplantation 2002; 73: 901-906
11. Stanger O, Weger M, Renner W, Konetschny R. Vascular dysfunction in hyperhomocyst(e)inemia. Implications for atherothrombotic disease. Clin Chem Lab Med 2001; 39: 725-733
12. Minniti G, Piana A, Armani U, Cerone R. Determination of plasma and serum homocysteine by high-performance liquid chromatography with fluorescence detection. J Chromatogr A 1998; 828: 401-405
13. Ueland PM, Refsum H, Beresford SA, Vollset SE. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr 2000; 72: 324-332
14. Mahony JF. Long term results and complications of transplantation: the kidney. Transplant Proc 1989; 21: 1433-1434
15. Shemin D, Bostom AG, Selhub J. Treatment of hyperhomocysteinemia in end-stage renal disease. Am J Kidney Dis 2001; 38: S91-S64
16. Hannedouche TP, Kunz K, Muller S, Chantrel F. Homocysteine and chronic renal failure. Adv Nephrol Necker Hosp 1998; 28: 287-310
17. Bostom AG, Gohh RY, Beaulieu AJ, Han H, Jacques PF, Selhub J, et al. Determinants of fasting plasma total homocysteine levels among chronic stable renal transplant recipients. Transplantation 1999; 68: 257-261
18. Ducloux D, Motte G, Challier B, Gibey R, Chalopin JM. Serum total homocysteine and cardiovascular disease occurrence in chronic, stable renal transplant recipients: a prospective study. J Am Soc Nephrol 2000; 11: 134-137
19. Brattstrom L, Lindgren A, Israelsson B, Andersson A, Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 1994; 236: 633-641
20. Friedman AN, Bostom AG, Selhub J, Levey AS, Rosenberg IH. The kidney and homocysteine metabolism. J Am Soc Nephrol 2001; 12: 2181-2189
21. Brosnan JT, Hall B, Selhub J, Nadeau MR, Bostom AG. Renal metabolism of homocysteine in vivo. Biochem Soc Trans 1995; 23: 470S
22. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 2001; 73: 613-621
23. Koehler KM, Romero LJ, Stauber PM, Pareo-Tubbeh SL, Liang HC, Baumgartner RN, et al. Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women. J Am Coll Nutr 1996; 15: 364-376
24. Lussier-Cacan S, Xhignesse M, Piolot A, Selhub J, Davignon J, Genest J Jr. Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits. Am J Clin Nutr 1996; 64: 587-593
25. Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 1995; 274: 1526-1533
26. Hirsch S, Poniachick J, Avendano M, Csendes A, Burdiles P, Smok G, et al. Serum folate and homocysteine levels in obese females with non-alcoholic fatty liver. Nutrition. 2005; 1(2): 137-141
27. Shihab FS. Cyclosporine nephropathy: pathophysiology and clinical impact. Semin Nephrol 1996; 16: 536-537
28. Quiroga I, Morris-Stiff G, Baboo R, Darby CR, Lord RH, Jurewicz WA. Differential homocysteine levels in renal transplant patients receiving neoral versus tacrolimus. Transplant Proc 2001; 33: 1209-1210
29. Fernandez-Miranda C, Gomez P, Diaz-Rubio P, Estenoz J, Carillo JL, Andres A, Morales JM. Plasma homocysteine levels in renal transplanted patients on cyclosporine or tacrolimus therapy: effect of treatment with folic acid. Clin Transplant 2000; 14: 110-114
30. Fernandez-Miranda C, Sanz M, de La Calle A, Loinaz C, Gomez P, Diaz-Rubio P, et al. Determinants of increased plasma homocysteine in 221 stable liver transplant patients. Clin Chem 2001; 47: 2037-2040