Hyperhomocysteinemia in renal transplant recipients

American Journal of Transplantation

Volumn 2, Issue 4, 2002, Pages 308-313

  Friedman, Allon N ^a,b   Rosenberg, Irwin H ^a   Selhub, Jacob ^a   Levey, Andrew S ^b   Bostom, Andrew G ^a,c  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

Author keywords

Cardiovascular disease; Homocysteine; Kidney; Renal transplant

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO; PYRIDOXINE;

AMINO ACID METABOLISM; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DIET SUPPLEMENTATION; GENETIC POLYMORPHISM; HEMODIALYSIS; HUMAN; HYPERHOMOCYSTEINEMIA; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; ORGAN TRANSPLANTATION; PREVALENCE; RISK FACTOR; SHORT SURVEY;

CARDIOVASCULAR DISEASES; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; KIDNEY TRANSPLANTATION; RISK FACTORS;

EID: 0036556161     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-6143.2002.20404.x     Document Type: Short Survey

References (54)

1. Annual United States Renal Data System Report. Am J Kidney Dis 2001; 38 (Suppl. 3): S1-245.
2. Kasiske B. Risk factors for accelerated atherosclerosis in renal transplant recipients. Am J Med 1988; 84: 985-992.
3. Sarnak M, Levey A. Cardiovascular disease and chronic renal disease: a new paradigm. Am J Kidney Dis 2000; 35: S117-131.
4. Kasiske B, Chakkera H, Roel J. The ability of traditional risk factors to predict ischemic heart disease in renal transplant recipients [Abstract]. J Am Soc Nephrol 1999; 10: 734A.
5. Mudd S, Finkelstein J, Refsum H et al. Homocysteine and its disulfide derivatives: a suggested consensus terminology. Arterioscler Thromb Vasc Biol 2000; 20: 1704-1706.
6. Selhub J, Miller J. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 1992; 55: 131-138.
7. Selhub J, Jacques P, Wilson P, Rush D, Rosenberg I. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J Am Med Assoc 1993; 270: 2693-2697.
8. Jacques P, Selhub J, Bostom A, Wilson P, Rosenberg I. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. New Engl J Med 1999; 340: 1449-1454.
9. Kang S, Wong P, Malinow M. Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr 1992; 12: 279-297.
10. Bostom A, Gohh R, Liaugaudas G et al. Prevalence of mild fasting hyperhomocysteinemia in renal transplant versus coronary artery disease patients after fortification of cereal grain flour with folic acid. Atherosclerosis 1999; 145: 221-224.
11. Bostom A, Gohh R, Beaulieu A et al. Determinants of fasting plasma total homocysteine levels among chronic stable renal transplant recipients. Transplantation 1999; 68: 257-261.
12. Woodside J, Fogarty D, Lightbody J et al. Homocysteine and B-group vitamins in renal transplant patients. Clin Chim Acta 1999; 282: 157-166.
13. Fonseca I. Queiros J, Santos M et al. Hyperhomocysteinemia in renal transplantation: preliminary results. Transplant Proc 2000; 32: 2602-2604.
14. Arnadottir M, Hultberg B, Viadov V, Nilsson-Ehle P, Thysell H. Hyperhomocysteinemia in cyclosporine-treated renal transplant recipients. Transplantation 1996; 61: 509-512.
15. Ducloux D, Motte G, Challier B, Gibey R, Chalopin J. Serum total homocysteine and cardiovascular disease occurrence in chronic, stable renal transplant recipients: a prospective study. J Am Soc Nephrol 2000; 11: 134-137.
16. Bostom A, Gohh R, Tsai M et al. Excess prevalence of fasting and postmethionine-loading hyperhomocysteinemia in stable renal transplant recipients. Arterioscler Thromb Vasc Biol 1997; 17: 1894-1900.
17. Bostom A, Kronenberg F, Jacques PF et al. Proteinuria and total plasma homocysteine levels in chronic renal disease patients with a normal range serum creatinine: critical impact of true GFR. Atherosclerosis 2001; 159: 219-223.
18. Arnadottir M, Hultberg B, Nilsson-Ehle P, Thysell H. The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. J Clin Lab Invest 1996; 56: 41-46.
19. Wolleson F, Brattsrom L, Refsum H, Ueland P, Berglund L, Berne C. Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. Kidney Int 1999; 55: 1028-1035.
20. Bostom A, Kronenberg F, Gohh R et al. Chronic renal transplantation: a model for the hyperhomocysteinemia of renal insufficiency. Atherosclerosis 2001; 15: 227-230.
21. Mudd S. Skovby F, Levy H, Pettigew K, Wilcken B, Pyeritz R. Natural history of hyomocystinuria due to cystathionine beta synthase deficiency. J Inherit Metab Dis 1985; 20 (2): 295-300.
22. Eikelboom J, Lonn E, Genest J, Hankey G, Yusuf S. Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann Intern Med 1999; 131: 363-375.
23. Ueland P, Refsum H, Beresford S, Vollset S. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr 2000; 72: 324-332.
24. Bostom A, Culleton B. Hyperhomocysteinemia in chronic renal disease. J Am Soc Nephrol 1999; 10: 891-900.
25. Brattstrom L Lindgren A, Israelsson B, Andersson A, Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged to elderly subjects. J Intern Med 1994; 236: 633-641.
26. Han H, Dwyer J, Selhub J et al. Determinants of plasma total homocysteine levels in korean chronic renal transplant recipients. J Renal Nutr 2000; 10: 202-207.
27. Aras O, Tsai M, Hanson N, Bailey R, Rao G, Hunninghake D. Cystatin C is an independent predictor of fasting and post-methionine load total homocysteine concentrations among stable renal transplant recipients. Clin Chem 2001; 47 (7): 1263-1268.
28. Bostom A, Gohh R, Bausserman L et al. Serum cystatin C as a determinant of fasting total homocysteine levels in renal transplant recipients with a normal serum creatinine. J Am Soc Nephrol 1999; 10: 164-166.
29. Friedman A, Bostom A, Selhub J, Levey A, Rosenberg I. The kidney and homocysteine metabolism. J Am Soc Nephrol 2001; 12: 2181-2189.
30. Guttormsen A, Ueland P, Svarstad E, Refsum H. Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure. Kidney Int 1997; 52: 495-502.
31. Refsum H, Hellnad S, Ueland P. Radioenzymatic determination of homocysteine in plasma and urine. Clin Chem 1985; 31: 624-628.
32. Finkelstein J. Methionine metabolism in mammals. J Nutr Biochem 1990; 1: 228-237.
33. Silbernagl S. The renal handling of amino acids and oligopeptides. Physiol Rev 1988; 68: 911-1007.
34. Bostom A, Brosnan J, Hall B, Nadeau M, Selhub J. Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis 1995; 116: 59-62.
35. Foreman J, Wald H, Blumberg G, Pepe L, Segal S. Homocystine uptake in isolated rat renal cortical tubules. Metabolism 1982; 31: 613-619.
36. Van Guldener C, Donker A, Jakobs C, Teerlink T, de Meer K, Stehouwer C. No net renal extraction of homocysteine in fasting humans. Kidney Int 1998; 54: 166-169.
37. Lussier-Cacan S, Xhignesse M, Piolot A, Selhub J, Davignon J, Genest J. Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits. Am J Clin Nutr 1996; 64: 587-593.
38. Green R, Chong YY, Jacobsen DW, Robinson K, Gupta M. Serum homocysteine is high in hypothyroidism: a possible link with coronary artery disease. Irish J Med Sci 1995; 164(S15): 27-28.
39. Rosenblatt D. Inherited Disorders of Folate Transport and Metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. Metabolic Basis of Inherited Disease, 6th edn. New York, NY: McGraw-Hill: 1989, 2049-2064.
40. Fodinger M, Buchmayer H, Heinz G et al. Effect of MTHFR 1298A →C and MTHFR 677C →T genotypes on total homocysteine, folate, and vitamin b12 plasma concentrations in kidney graft recipients. J Am Soc Nephrol 2000; 11: 1918-1925.
41. Fodinger M, Wolfl G, Fischer G et al. Effect of MTHFR 677C>T on plasma total homocysteine levels in renal graft recipients. Kidney Int 1999; 55: 1072-1080.
42. Cossu M, Carru C, Pes G et al. Plasma homocysteine levels and C677T MTHFR gene polymorphism in stable renal graft recipients. Transplant Proc 2001; 33: 1156-1158.
43. Botto L, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a huge review. Am J Clin Nutr 2000; 72: 324-332.
44. Jacques P, Bostom A, Williams R et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93: 7-9.
45. Marcucci R, Fedi S, Brunelli T et al. High cysteine levels in renal transplant recipients. Transplantation 2001; 71: 46-751.
46. Stein G, Muller A, Busch M, Fleck C, Spershneider H. Homocysteine, its metabolites, and B-group vitamins in renal transplant patients. Kidney Int 2001; 59(Suppl. 78): S62-65.
47. Ignatescu M, Fodinger M, Kletzmayr J, Bieglmayer C, Horl W, Sunder-Plassmann G. Is there a role of cyclosporine a on total homocysteine export from human renal proximal tubular epithelial cells? Kidney Int 2001; 59(Suppl. 78): S258-261.
48. Homocysteine Lowering Trialists Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Br Med J 1998; 316: 894-898.
49. Beaulieu A, Gohh R, Han H et al. Enhanced reduction of fasting total homocysteine levels with supraphysiological versus standard multivitamin dose folic acid supplementation in renal transplant recipients. Arterioscler Thromb Vasc Biol 1999; 19: 2918-2921.
50. Grandtnerova B, Laca L, Gabor D, Gregova E, Koronyi S. Folic acid supplementation and homocyst(e)ine level in renal transplant recipients. Transplant Proc 2001; 33: 2049-2050.
51. Bostom A, Gohh R, Beaulieu A et al. Treatment of hyperhomocysteinemia in renal transplant recipients: a randomized placebo-controlled trial. Ann Intern Med 1997; 127: 1089-1092.
52. Bostom A, Shemin D, Gohh R et al. Treatment of hyperhomocysteinemia in hemodialysis patients and renal transplant recipients. Kidney Int 2001; 59(Suppl. 78): S46-52.
53. Bostom A, Selhub J, Jacques P, Rosenberg I. Power shortage, clinical trials testing the 'homocysteine hypothesis' against a background of folic acid-fortified cereal grain flour. Ann Intern Med 2001; 135: 133-137.
54. Kilner J. Selecting patients when resources are limited, a study of us medical directors of kidney dialysis and transplantation facilities. Am J Public Health 1988; 78: 144-147.