Plasma homocysteine levels in renal transplanted patients on cyclosporine or tacrolimus therapy: Effect of treatment with folic acid

Clinical Transplantation

Volumn 14, Issue 2, 2000, Pages 110-114

  Fernández Miranda, Consuelo ^a   Gómez, Pilar ^a   Díaz Rubio, Pilar ^a   Estenoz, Juana ^a   Carrillo, Juan Luis ^a   Andrés, Amado ^a   Morales, José M ^a  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

Cyclosporine; Folic acid; Homocysteine; Lipoproteins; Renal transplanted patients; Tacrolimus

Indexed keywords

CREATININE; CYANOCOBALAMIN; CYCLOSPORIN A; FOLIC ACID; HOMOCYSTEINE; LIPOPROTEIN; PREDNISONE; TACROLIMUS;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; CREATININE CLEARANCE; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL;

ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHOLESTEROL; CREATININE; CYCLOSPORINE; FEMALE; FOLIC ACID; HEMATINICS; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RISK FACTORS; TACROLIMUS; TRIGLYCERIDES; VITAMIN B 12;

EID: 0343851159     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0012.2000.140202.x     Document Type: Article

References (24)

1. GRAHAM IM, DALY LE, REFSUM HM et al. Plasma homocysteine as a risk factor for vascular disease. JAMA 1997: 277: 1775.
2. WALD NJ, WATT HC, LAW MR, WEIK DG, MCPARTLIN J, SCOTT JM. Homocysteine and ischemic heart disease: results of a prospective study with implications regarding prevention. Arch Intern Med 1998: 158: 862.
3. VERHOEF P, HENNEKENS CH, MALINOW MR, KOK FJ, WILLETT WC, STAMPFER MJ. A prospective study of plasma homocysteine and risk of ischemic stroke. Stroke 1994: 25: 1924.
4. NYGARD O, REFSUM H, UELAND PM, FARSTAD M, VOLLSET SE, NORDREHAUG JE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997: 337: 1632.
5. KASISKE BL. Risk factors for accelerated atherosclerosis in renal transplant recipients. Am J Med 1988: 84: 985.
6. WILKEN DEL, GUPTA VJ, BETTS AK. Homocysteine in the plasma of renal transplant recipients: effects of cofactors for methionine metabolism. Clin Sci 1981: 61: 743.
7. MASSY ZA, CHADEFAUX-VEKEMENS B, CHEVALIER A et al. Hyperhomocysteinaemia: a significant risk factor for cardiovascular disease in renal transplant recipients. Nephrol Dial Transplant 1994: 9: 1103.
8. ARDANOTTIR M, HULTBERG B, VLADOV V, NILSSONEHLE P, THYSELL H. Hyperhomocysteinemia in cyclosporine treated renal transplant recipients. Transplantation 1996: 61: 509.
9. BOSTOM AG, GOHH RY, TSAI MY, JACQUES PF, ROSENBERG IH, SELHUB J. Excess prevalence of fasting and postmethionine-loading hyperhomocysteinemia in stable renal transplant recipients. Arterioscl Thromb Vasc Biol 1997: 17: 1894.
10. DUCLOUX D, RUEDIN C, GIBEY R, CHALOPIN JM. Prevalence, determinants, and clinical significance of hyperhomocyst(e)inemia in renal-transplant recipients. Nephrol Dial Transplant 1998: 13: 2890.
11. FOGARTY DG, WOODSIDE J, LIGHTBODY JH, MAXWELL AP. Plasma homocysteine in renal transplant recipients. J Am Soc Nephrol 1996: 7: 1931.
12. HOMOCYSTEINE LOWERING TRIALISTS' COLLABORATION. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Br Med J 1998: 316: 894.
13. ARNADOTTIR M, HULTBERG B. Treatment with high-dose folic acid effectively lowers plasma homocysteine concentration in cyclosporine-treated renal transplant recipients. Transplantation 1997: 64: 1087.
14. BOSTOM AG, GOHH RY, BEAULIEU AJ et al. Treatment of hyperhomocysteinemia in renal transplant recipients: a randomized, placebo-controlled trial. Ann Intern Med 1997: 127: 1089.
15. SHIPCHANDLER MT, MOORE EE. Rapid, fully automated measurement of plasma homocysteine with the Abbott lmx analyser. Clin Chem 1995: 41: 991.
16. FONTANALS-FERRER N, SERRAT-SERRAT J, SORRIBAS-VIVAS A, GONZALEZ-GARCIA C, GONZALEZ-SASTRE F, GOMEZ-GERIQUE J. Quick method of determining lipoproteins, including those of intermediate density, in serum. Clin Chem 1988: 34: 1753.
17. ARNADOTTIR M, HULTBERG B, NILSSON-EHLE P, THYSELL H. The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand Clin Lab Invest 1996: 56: 41.
18. CHAUVEAU P, CHADEFAUX B, COUDÉ M et al. Increased plasma homocysteine concentration in patients with chronic renal failure. Miner Electrolyte Metab 1992: 18: 196.
19. FÖDINGER M, WÖLFL G, FISCHER G et al. Effect of MTHFR 677C > T on plasma total homocysteine levels in renal graft recipients. Kidney Int 1999: 55: 1072.
20. ARNADOTTIR M, HULTBERG B, WAHLBERG J, FELLSTRÖM B, DIMENY E. Serum total homocysteine concentration before and after renal transplantation. Kidney Int 1998: 54: 1380.
21. MCCUNE TR, THACKER II LR, PETERS TG et al. Effects of tacrolimus on hyperlipidemia after successful renal transplantation. Transplantation 1998: 65: 87.
22. BRAUN WE, PROTIVA DA, GIFFORD RW, STRAFFON RA. Hyperhomocysteinemia and other coronary risk factors in 20-year renal transplant recipients (level 5A) with and without coronary heart disease. Transplant Proc 1999: 31: 1280.
23. BRATTSTROM LE, ISRAELSSON B, JEPPSSON JO, HULTBERG BL. Folic acid - an innocuous means to reduce plasma homocysteine. Scand J Clin Lab Invest 1988: 48: 215.
24. MOGHADASIAN MH, MCMANUS BM, FROHLICH JJ. Homocyst(e)ine and coronary artery disease. Arch Intern 1997: 157: 2299.