Dietary sphingolipids suppress a subset of preneoplastic rat liver lesions exhibiting high PTEN, low phospho-Akt and high levels of ceramide species

Food and Chemical Toxicology

Volumn 44, Issue 9, 2006, Pages 1552-1561

  Silins, Ilona ^a   Högberg, Johan ^a   Stenius, Ulla ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Akt; Cancer chemoprevention; Preneoplastic liver lesions; Protein kinase B; PTEN; Sphingolipids

Indexed keywords

AFLATOXIN; ANTISENSE OLIGODEOXYNUCLEOTIDE; CERAMIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SPHINGOLIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIET THERAPY; DRUG SENSITIVITY; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; LIVER CARCINOGENESIS; LIVER CELL CULTURE; LIVER INJURY; NONHUMAN; PRECANCER; PROTEIN BLOOD LEVEL; RAT; TISSUE SECTION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CERAMIDES; DIET; DRUG COMBINATIONS; FEMALE; GLUTATHIONE TRANSFERASE; HEPATOCYTES; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; OLIGONUCLEOTIDES, ANTISENSE; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOMYELINS; SPHINGOSINE;

EID: 33745601925     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.04.001     Document Type: Article

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