Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells

Pigment Cell Research

Volumn 14, Issue 2, 2001, Pages 110-115

  Dong Seok, K I M ^a   Sook Young, K I M ^a   Moon, Seong Joon ^b   Chung, Jin H O ^a   Kyu Han, K I M ^a   Kwang Hyun, C H O ^a   Park, Kyoung Chan ^a,b  

^a Seoul National University   (South Korea)

^b AmorePacific Corporation   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AKT1 PROTEIN, HUMAN; DRUG DERIVATIVE; ENZYME INHIBITOR; MELANIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOPHENOL MONOOXYGENASE; N ACETYLSPHINGOSINE; N-ACETYLSPHINGOSINE; ONCOPROTEIN; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SPHINGOSINE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL DIVISION; CELL LINE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; MELANOCYTE; MELANOMA; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; CELL DIVISION; CELL LINE; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MELANINS; MELANOCYTES; MELANOMA; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MONOPHENOL MONOOXYGENASE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SPHINGOSINE;

ANIMALIA;

EID: 0035096712     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0749.2001.140206.x     Document Type: Article

References (31)

1. The sphingomyelin cycle and the second messenger function of ceramide
2. Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts
3. Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence
4. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha
5. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation
6. Keratinocyte differentiation is induced by cell-permeable ceramides and its proliferation is promoted by sphingosine
7. Antitumor activity of alpha-galactosylceramide, KRN7000, in mice with EL-4 hepatic metastasis and its cytokine production
8. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
9. The role of PI 3-kinase in insulin action
10. Mechanism of activation of protein kinase B by insulin and IGF-1
11. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
12. Development of an in vitro primary screen for skin depigmentation and antimelanoma agents
13. Effects of growth factors on the proliferation of human keratinocytes and fibroblasts in vitro
14. Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma
15. Melanocyte-stimulating properties of arachidonic acid metabolites: Possible role in postinflammatory pigmentation
16. Functions of ceramide in coordinating cellular responses to stress
17. Role of ceramide in mitogenesis induced by exogenous sphingoid bases
18. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
19. Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation
20. The vitamin D3 analogue, calcipotriol, induces sphingomyelin hydrolysis in human keratinocytes
21. Ceramide stimulates a cytosolic protein phosphatase
22. Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase
23. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid
24. Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades
25. A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase
26. Role of AKT1 in 17beta-estradiol and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells
27. The Akt proto-oncogene links Ras to Pak and cell survival signals
28. Lipid-regulated kinases: Some common themes at last
29. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
30. A potential role for ceramide in the regulation of mouse epidermal keratinocyte proliferation and differentiation
31. Induction of melanogenesis suppression: Cellular pharmacology and mode of differential action