Vascular Endothelial Cells Produce Soluble Factors That Mediate the Recovery of Human Hematopoietic Stem Cells after Radiation Injury

Biology of Blood and Marrow Transplantation

Volumn 12, Issue 5, 2006, Pages 530-540

  Muramoto, Garrett G ^a   Chen, Benny ^a   Cui, Xiuyu ^a   Chao, Nelson J ^a   Chute, John P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hematopoietic stem cells; Radiation injury; Rescue; Vascular endothelial cells

Indexed keywords

CD34 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL REGENERATION; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; MOUSE; NONHUMAN; RADIATION EXPOSURE; RADIATION INJURY; SCID MOUSE; VASCULAR ENDOTHELIUM;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; COCULTURE TECHNIQUES; COLONY-FORMING UNITS ASSAY; CYTOKINES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FETAL BLOOD; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOPHENOTYPING; MICE; MICE, INBRED NOD; MICE, SCID; RADIATION INJURIES; TRANSPLANTATION, HETEROLOGOUS;

EID: 33745466139     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2005.12.039     Document Type: Article

References (50)

1. Augustine A.D., Gondre-Lewis T., McBride W., Miller L., Pellmar T., and Rockwell S. Animal models for radiation injury, protection and therapy. Radiat Res 164 (2005) 100-109
2. Wasalenko J., Waselenko J., Macvittie T., et al. Medical management of the acute radiation syndrome. recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med 140 (2004) 1037-1051
3. Mettler F., and Voelz G. Major radiation exposure-what to expect and how to respond. N Engl J Med 346 (2002) 1554-1561
4. Dainiak N. Hematologic consequences of exposure to ionizing radiation. Exp Hematol 30 (2002) 513-528
5. Albanese J., and Dainiak N. Ionizing radiation alters Fas ligand at the cell surface and on exfoliated plasma membrane-derived vesicles. implications for apoptosis and intercellular signaling. Radiat Res 153 (2000) 49-61
6. Belka C., Marini P., Budach W., et al. Radiation induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD9/Fas/APO-1 Ligand. Radiat Res 149 (1998) 588-595
7. Radford I., and Murphy T. Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage. Int J Radiat Biol 65 (1994) 229-239
8. Neta R., Oppenheim J., Wang J., et al. Synergy of IL-1 and SCF in radioprotection of mice is associated with IL-1 upregulation of mRNA and protein expression for c-kit on bone marrow cells. J Immunol 153 (1994) 1536-1543
9. Zsebo K., Smith K., Hartley C., et al. Radioprotection of mice by recombinant stem cell factor. Proc Natl Acad Sci U S A 89 (1992) 9464-9468
10. Neta R. Modulation with cytokines of radiation injury. suggested mechanism of action. Environ Health Persp 107 suppl 6 (1995) 1463-1465
11. Karkanitsa L., Komarovskaya M., and Krivenko S. Abrogation of radiation injury to human hematopoietic stem cells with tumor necrosis factor-alpha. Stem Cells 15 suppl 2 (1997) 95-102
12. Pestina T., Cleveland J., Yang C., Zambetti G., and Jackson C. Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis. Blood 98 (2001) 2084-2090
13. Herodin F., Bourin P., Mayol J., Lataillade J., and Drouet M. Short term injection of antiapoptotic cytokine combinations soon after lethal γ-irradiation promotes survival. Blood 101 (2003) 2609-2616
14. Macvittie T., Farese A., and Jackson W. Defining the full therapeutic potential of recombinant growth factors in the post radiation accident environment. the effect of supportive care plus administration of recombinant G-CSF. Health Phys 89 (2005) 546-555
15. Farese A., Macvittie T., Roskos L., and Stead R. Hematopoietic recovery following autologous bone marrow transplantation in a non-human primate. effect of variation of treatment schedule with PEG-rHuMGDF. Stem Cells 21 (2003) 79-89
16. Neelis K., Visser T., Dimjati W., et al. A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen repopulating cells at the transient expense of bone marrow repopulating cells. Blood 92 (1998) 1586-1597
17. Hudak S., Leach M., Xu Y., Menon S., and Rennick D. Radioprotective effects of flk2/flt3 ligand. Exp Hematol 26 (1998) 515-522
18. Mouthon M., Van der Meeren A., Gaugler M., et al. Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation. Int J Radiat Oncol Biol Phys 43 (1999) 867-875
19. Chute J., Fung J., Muramoto G., and Erwin R. Ex vivo culture rescues hematopoietic stem cells with long term repopulating capacity following harvest from lethally irradiated mice. Exp Hematol 32 (2004) 308-317
20. + cells with porcine microvascular endothelial cells results in a graft capable of rescuing lethally irradiated baboons. Blood 94 (1999) 106-113
21. Chute J., Saini A., Chute D., et al. Ex vivo culture with human brain endothelial cells increases the SCID-repopulating capacity of adult human bone marrow. Blood 100 (2002) 4433-4439
22. Zhang J., Niu C., Ye L., et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425 (2003) 836-841
23. Calvi L., Adams G., Weibrecht K., et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425 (2003) 841-846
24. Avecilla S., Hattori K., Heissig B., et al. Chemokine mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 10 (2004) 64-71
25. Chute J.P., Fung J., Muramoto G., and Oxford C. Quantitative analysis demonstrates expansion of SCID-repopulating cells (SRC) and increased engraftment capacity within human cord blood cells following culture with human brain endothelial cells. Stem Cells 22 (2004) 202-215
26. - cells and SCID repopulating cells. Blood 105 (2005) 576-583
27. + cell proliferation and differentiation. Stem Cells 17 (1999) 273-285
28. Schulz L., Schweitzer P., Christianson S., et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 154 (1995) 180-191
29. + cells in bone marrow by flow cytometry. J Hematother 2 (1993) 305-313
30. Glimm H., and Eaves C. Direct evidence for multiple self-renewal divisions of human in vivo repopulating cells in short-term culture. Blood 94 (1999) 2161-2168
31. - cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency. dissociation of SRC phenotype and function. Blood 95 (2000) 102-110
32. + cord blood cells after ex vivo expansion. evidence for the amplification and self-renewal of repopulating stem cells. Blood 93 (1999) 3736-3749
33. Tanavde V., Malehorn M., Lumkul R., et al. Human stem-progenitor cells from neonatal cord blood have greater hematopoietic expansion capacity than those from mobilized adult blood. Exp Hematol 30 (2002) 816-823
34. Gale R. Immediate medical consequences of nuclear accidents. Lessons from Chernobyl. JAMA 258 (1987) 625-628
35. Baranov A., Gale R., Guskova A., et al. Bone marrow transplantation after the Chernobyl nuclear accident. N Engl J Med 321 (1989) 205-212
36. Drouet M., Mourcin F., Grenier N., et al. Single administration of stem cell factor, FLT-3 ligand, megakaryocyte growth and development factor, and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression. long-term follow up of hematopoiesis. Blood 103 (2004) 878-885
37. Farese A., Hunt P., Grab L., and MacVittie T. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia. J Clin Invest 97 (1996) 2145-2151
38. Farese A., Casey D., Vigneulle R., et al. A single dose of pegylated leridistim significantly improves neutrophil recovery in sublethally irradiated rhesus macaques. Stem Cells 19 (2001) 514-521
39. Farese A., Casey D., Smith W., et al. Leridistim, a chimeric dual GCSF and IL-3 receptor agonist, enhances multilineage hematopoietic recovery in a nonhuman primate model of radiation induced myelosuppression. effect of schedule, dose and route of administration. Stem Cells 19 (2001) 522-533
40. Tanikawa S., Nose M., Aoki Y., et al. Effects of recombinant granulocyte colony stimulating factor on the hematologic recovery and survival of irradiated mice. Blood 76 (1990) 445-449
41. Quelle F., Wang J., Feng J., et al. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. Genes Dev 12 (1998) 1099-1107
42. Henry M., Lynch J., Eapen A., and Quelle F. DNA damage induced cell cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway. Blood 98 (2001) 834-841
43. Campanini F., Santucci M., Brusa G., et al. Expression of p21 (WAF1/CIP1/SID1) cyclin dependent kinase inhibitor in hematopoietic progenitor cells. Gene 273 (2001) 173-180
44. Tsai S., Fero J., and Bartelmez S. Mouse jagged 2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. Blood 96 (2000) 950-957
45. Mathieu C., Fouchet P., Gauthier L., Lassalle B., Boussin F., and Mouthon M. Coculture with endothelial cells reduces the population of cycling LeX neural precursors but increases that of quiescent cells with a side population phenotype. Exp Cell Res 312 (2006) 707-718
46. Chute J., Clark W., Johnson K., Saini A., Wells M., and Harlan D. Hematopoietic cytokine production by human brain endothelial cells (HUBEC) is associated with the ex vivo expansion of CD34+CD38- progenitor cells. Exp Hematol 28 (2000) 96a
47. + cells in the presence of SCF, Flt-3 ligand, TPO and IL-3. potential application to autologous cell therapy in accidentally irradiated victims. Radiat Res 164 (2005) 1-9
48. + cells from radiation-induced apoptosis and sustain hematopoietic reconstitution after coculture and cografting in lethally irradiated baboons. is autologous stem cell therapy in nuclear accident settings hype or reality?. Bone Marrow Transplant 35 (2005) 1201-1209
49. Kong D., Melo L., Gnecchi M., et al. Cytokine induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries. Circulation 110 (2004) 239-246
50. Kopp H., Avecilla S., Hooper A., et al. Tie-2 activation contributes to hemangiogenic revascularization after myelosuppression. Blood 106 (2005) 505-513