Immunohistochemical detection of hTERT protein in soft tissue sarcomas: Correlation with tumor grade

Applied Immunohistochemistry and Molecular Morphology

Volumn 14, Issue 2, 2006, Pages 198-202

  Sabah, Muna ^a   Cummins, Robert ^a   Leader, Mary ^a   Kay, Elaine ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

Grade; hTERT; Human telomerase reverse transcriptase; Soft tissue sarcomas

Indexed keywords

TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CELL IMMORTALIZATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME SUBUNIT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOFT TISSUE SARCOMA; TUMOR GROWTH;

HUMANS; IMMUNOHISTOCHEMISTRY; PREDICTIVE VALUE OF TESTS; SARCOMA; SOFT TISSUE NEOPLASMS; TELOMERASE;

EID: 33745348321     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/01.pai.0000156606.04726.d3     Document Type: Article

References (45)

1. Royle NJ. Telomeres and disease. J Pathol. 1996;180:233-235.
2. Blackburn EH. Structure and function of telomeres. Nature. 1991;350:569-573.
3. Moyzis RK, Buckingham JM, Cram LS, et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA. 1988;85:6622-6626.
4. de Lange T. Human telomeres are attached to the nuclear matrix. EMBO J. 1992;11:717-724.
5. Kirk KE, Harmon BP, Reichardt IK, et al. Block in anaphase chromosome separation caused by a telomerase template mutation. Science. 1997;275:1478-1481.
6. Harley CB. Telomere loss: mitotic clock or genetic time bomb? Mutat Res. 1991;256:271-282.
7. Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science. 1995;269:1236-1241.
8. Bryce LA, Morrison N, Hoare SF, et al. Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization. Neoplasia. 2000;2:197-201.
9. Nakamura TM, Morin GB, Chapman KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science. 1997;277:955-959.
10. Harrington L, McPhail T, Mar V, et al. A mammalian telomeraseassociated protein. Science. 1997;275:973-977.
11. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer. 1997;33:787-791.
12. Aogi K, Woodman A, Urquidi V, et al. Telomerase activity in soft-tissue and bone sarcomas. Clin Cancer Res. 2000;6:4776-4781.
13. Yoo J, Robinson RA. Expression of telomerase activity and telomerase RNA in human soft tissue sarcomas. Arch Pathol Lab Med. 2000;124: 393-397.
14. Schneider-Stock R, Rys J, Jaeger V, et al. Prognostic significance of telomerase activity in soft tissue sarcomas. Int J Oncol. 1999;15:775-780.
15. Yan P, Coindre JM, Benhattar J, et al. Telomerase activity and human telomerase reverse transcriptase mRNA expression in soft tissue tumors: correlation with grade, histology, and proliferative activity. Cancer Res. 1999;59:3166-3170.
16. Schneider-Stock R, Epplen JT, Walter H, et al. Telomeric lengths and telomerase activity in liposarcomas. Mol Carcinog. 1999;24:144-151.
17. Aue G, Muralidhar B, Schwartz HS, et al. Telomerase activity in skeletal sarcomas. Ann Surg Oncol. 1998;5:627-634.
18. Sangiorgi L, Gobbi GA, Lucarelli E, et al. Presence of telomerase activity in different musculoskeletal tumor histotypes and correlation with aggressiveness. Int J Cancer. 2001;95:156-161.
19. Tomoda R, Seto M, Tsumuki H, et al. Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. Cancer. 2002;95: 1127-1133.
20. Fletcher CD, Unni KK, Mertens F. Pathology and Genetics of Tumours of Soft Tissue and Bone. Oxford University Press; 2002.
21. Guillou L, Coindre JM, Bonichon F, et al. Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol. 1997;15:350-362.
22. Weiss SW, Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors. Mosby; 2001.
23. Hiyama E, Hiyama K, Yokoyama T, et al. Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues. Neoplasia. 2001;3:17-26.
24. Sabah M, Cummins R, Leader M, et al. Expression of hTERT in gastrointestinal stromal tumours occurs preferentially in malignant neoplasms. Hum Pathol. 2004;35:1231-1235.
25. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994;266:2011-2015.
26. Liu Y, Snow BE, Hande MP, et al. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol. 2000;10:1459-1462.
27. Ulaner GA, Hu JF, Vu TH, et al. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 1998;58:4168-4172.
28. Arai K, Masutomi K, Khurts S, et al. Two independent regions of human telomerase reverse transcriptase are important for its olisomerization and telomerase activity. J Biol Chem. 2002;277:8538-8544.
29. Takakura M, Kyo S, Kanaya T, et al. Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res. 1998;58:1558-1561.
30. Hahn WC, Counter CM, Lundberg AS, et al. Creation of human tumour cells with defined genetic elements. Nature. 1999;400:464-468.
31. Wick M, Zubov D, Hagen G. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene. 1999;232:97-106.
32. Frost M, Bobak JB, Gianani R, et al. Localization of telomerase hTERT protein and hTR in benign mucosa, dysplasia, and squamous cell carcinoma of the cervix. Am J Clin Pathol. 2000;114:726-734.
33. Toomey D, Smyth G, Condron C, et al. Immune function, telomerase, and angiogenesis in patients with primary, operable non-small cell lung carcinoma: tumor size and lymph node status remain the most important prognostic features. Cancer. 2001;92:2648-2657.
34. Wei R, Younes M. Immunohistochemical detection of telomerase reverse transcriptase in colorectal adenocarcinoma and benign colonic mucosa. Hum Pathol. 2002;33:693-696.
35. Tahara H, Yasui W, Tahara E, et al. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections. Oncogene. 1999;18:1561-1567.
36. Kawakami Y, Kitamoto M, Nakanishi T, et al. Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues. Oncogene. 2000;19:3888-3893.
37. Reddel RR, Bryan TM, Murnane JP. Immortalized cells with no detectable telomerase activity. A review. Biochemistry (Mosc). 1997;62:1254-1262.
38. Bryan TM, Englezou A, Dalla-Pozza L, et al. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumorderived cell lines. Nat Med. 1997;3:1271-1274.
39. Etheridge KT, Banik SS, Armbruster BN, et al. The nucleolar localization domain of the catalytic subunit of human telomerase. J Biol Chem. 2002;277:24764-24770.
40. Lukowiak AA, Narayanan A, Li ZH, et al. The snoRNA domain of vertebrate telomerase RNA functions to localize the RNA within the nucleus. RNA. 2001;7:1833-1844.
41. Jaeger V, Schneider-Stock R, Gerresheim F, et al. Myxoid liposarcoma with transition to round-cell lesion-cell cycle regulator genes and telomerase activity characterizing tumor progression: a case report. Hum Pathol. 1999;30:1515-1519.
42. Schneider-Stock R, Boltze C, Jager V, et al. Elevated telomerase activity, c- MYCand hTERT mRNA expression: association with tumour progression in malignant lipomatous tumours. J Pathol. 2003;199:517-525.
43. Schneider-Stock R, Gerresheim F, Kolin-Gerresheim I, et al. Different mRNA expression profile during tumor progression in a well-differentiated liposarcoma: a microdissection approach. Pathol Res Pract. 2003;199:445-450.
44. Schneider-Stock R, Emrich T, Peters B, et al. Analysis of human telomerase reverse transcriptase mRNA (hTERT) expression in myxoid liposarcomas using LightCycler real-time quantitative reverse transcriptase-polymerase chain reaction. Electrophoresis. 2001;22:1098-1101.
45. Kleideiter E, Schwab M, Friedrich U, et al. Telomerase activity in cell lines of pediatric soft tissue sarcomas. Pediatr Res. 2003;54:718-723.