Molecular genetics of substance abuse vulnerability: A current approach

Neuropsychopharmacology

Volumn 20, Issue 1, 1999, Pages 3-9

  Uhl, George R ^a  

^a Molecular Neurobiology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIOR; DRUG ABUSE; GENETIC VARIABILITY; HUMAN; MOLECULAR GENETICS; NEUROPHARMACOLOGY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; TWINS;

ANIMALS; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; PEDIGREE; RECEPTORS, DRUG; SUBSTANCE-RELATED DISORDERS;

EID: 0032891298     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(98)00061-X     Document Type: Review

References (35)

1. Barcellos L.F., Klitz W., Field L.L., Tobias R., Bowcock A.M., Wilson R., Nelson M.P., Nagatomi J., Thomson G. Association mapping of disease loci by use of a pooled DNA genomic screen. Am J Hum Genetics. 61:1997;734-747.
2. Belknap J.K., O'Toole L.A. Studies of genetic differences in response to opioid drugs. Harris R.A., Crabbe J.C. The Genetic Basis of Alcohol and Drug Actions. 1991;225-252 Plenum Press, New York.
3. Belknap JK, Crabbe JC (1992); Chromosome mapping of gene loci affecting morphine and amphetamine responses in the BXD recombinant inbred mice. In Kalivas PW, Samson HH (eds), The neurobiology of drug and alcohol addiction. New York, The New York Academy of Sciences, pp 311-323.
4. Berettini W.H., Ferraro T.N., Alexander R.C., Buchberg A.M., Vogel W.H. quantitative trait loci mapping in three loci controlling morphine preference using inbred mouse strains. Nature Genet. 7:1994;54-58.
5. Cadoret R.J., O'Gorman T., Troughton E., Heywood E. An adoption study of genetic and environmental factors in drug abuse. Arch Gen Psych. 43:1986;1131-1136.
6. Cadoret R.J., Yates E., Troughton E., Woodworth G., Stewart M.A. Adoption study demonstrating two genetic pathways to drug abuse. Arch Gen Psychaitr. 52:1995;42-52.
7. Collins F.S., Guyer M.S., Chakravarti A. Variations on a theme. Cataloging human DNA sequence variation Science. 278:1997;1580-1581.
8. Crabbe J.C., Belknap J.K., Buck K.J. Genetic animal models of alcohol and drug abuse. Science. 264:1994;1715-1723.
9. Croughan J.L. The contribution of family studies to understanding drug abuse. Robbins L. Studying Drug Abuse. 1985;Rutgers University Press, New Brunswick, NJ.
10. 11C]-carfentanil binding to opiate receptors in humans measured by positron emission tomography. J Cereb Blood Flow Metab. 9:1995;398-409.
11. Goldberg J., Lyons M.J., Eisen S.A., True W.R., Tsuang M. Genetic influence on drug use. A preliminary analysis of 2,674 Vietnam era veteran twins Behav Genet. 23:1993;552.
12. Grove W.M., Eckert E.D., Heston L., Bouchard T.J., Segal N., Lykken D.T. Heritability of substance abuse and antisocial behavior. A study of monozygotic twins reared apart Biol Psychaitr. 27:1990;1293-1304.
13. Gynther L.M., Carey G., Gottesman I., Vogler G.P. A twin study of nonalcohol substance abuse. Psychaitr Res. 56:1995;213-220.
14. Hill S.Y., Cloninger C.R., Ayre F.R. Independent familial transmission of alcoholism and opiate abuse. Alcohol Clin Exper Res. 1:1977;335-342.
15. Institute of Medicine, Committee on Opportunities in Drug Abuse Research (1996): Pathways of Addiction. Washington, DC, National Academy Press.
16. Johnson E.O., van den Bree M.B., Uhl G.R., Pickens R.W. Indicators of genetic and environmental influences in drug-abusing individuals. Drug Alcohol Depend. 41:1996;17-23.
17. 2 receptors. Nature. 388:1997;586-589.
18. Ott J (1991): Analysis of Human Genetic Linkage. Baltimore: Johns Hopkins University Press.
19. Pfeiffer A., Pasi A., Mehraein P., Herz A. Opiate receptor binding sites in human brain. Brain Res. 248:1982;887-896.
20. Pickens R.W., Svikis D.S., McGue M., LaBuda M.C. Common genetic mechanisms in alcohol, drug, and mental disorder co-morbidity. Drug Alcohol Depend. 39:1995;129-138.
21. Pickens R.W., Svikis D.S., McGue M., Lykken D.T., Heston L.L., Clayton P.J. Heterogeneity in the inheritance of alcoholism. A study of male and female twins Arch Gen Psych. 48:1991;19-28.
22. Regier D.A., Farmer M.E., Rae D.S., Locke B.Z., Keith S.J., Judd L.L., Goodwin F.K. Comorbidity of mental disorders with alcohol and other drug abuse. JAMA. 264:1990;2511-2518.
23. Risch N. Linkage strategies for genetically complex traits. Am J Hum Genetics. 46:1990;222-232.
24. Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
25. Rounsaville B.J., Kosten T.R., Weissman M.M., Prusoff B., Pauls D.L., Anton S.F., Merikangas K. Psychiatric disorders in relatives of probands with opiate addiction. Arch Gen Psych. 48:1991;33-42.
26. Substance Abuse and Mental Health Services Administration (SAMHSA) (1995): National Household Survey on Drug Abuse: Population Estimates. Washington, DC, U.S. Dept. of Health and Human Services.
27. Sora I., Takahashi N., Funada M.et al. Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Nat Acad Sci. 94:1997;1544-1549.
28. Syvanen A.C., Tilgmann C., Rinne J., Ulmanen I. Genetic polymorphism of catechol-O-methyltransferase (COMT). correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland Pharmacogenetics. 7:1997;65-71.
29. Takahashi N., Miner L.M., Sora I.et al. VMAT2 knockout mice. Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity Proc Nat Acad Sci. 94:1997;9938-9943.
30. Tsuang M.T., Lyons M.J., Eisen S.A., Goldberg J., True W., Li N., Meyer J.M., Toomey R., Faraone S.V., Eaves L. Genetic influences on DSM-III-R drug abuse and dependence. A study of 3,372 twin pairs Am J Med Genet. 67:1996;473-477.
31. Uhl G.R., Elmer G.I., Labuda M.C., Pickens R.W. Genetic influences in drug abuse. Bloom F.E., Kupfer D.J. Psychopharmacology. The Fourth Generation of Progress:1995;1793-1806 Raven Press, New York.
32. Uhl G.R., Gold L.H., Risch N. Genetic analyses of complex behavioral disorders. Proc Nat Acad Sci. 94:1997;2785-2786.
33. Uhl G.R., Vandenbergh D.J., Rodriguez A.L., Miner L., Takayashi N. Dopaminergic genes and substance abuse. Adv Pharmacology. 42:1998;1024-1032.
34. Wilens T.E., Biederman J., Mick E., Faraone S.V., Spencer T. Attention deficit hyperactivity disorder (ADHD) is associated with early onset substance use disorders. J Nerv Ment Dis. 185:1997;475-482.
35. Woodward C.E., Maes H.H., Silberg J.L., Meyer J.M., Eaves L.J. Tobacco, alcohol, and drug use in 8-16-year-old-twins. NIDA Res Monogr. 162:1996;309.