Total synthesis and biological assessment of cyclopropane-based epothilone analogues - Modulation of drug efflux through polarity adjustments

Synlett

Volumn , Issue 9, 2006, Pages 1384-1388

  Cachoux, Fréderic ^a,c   Isarno, Thomas ^a,d   Wartmann, Markus ^b   Altmann, Karl Heinz ^a  

^a ETH ZURICH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Prestwick Chemical Inc   (France)

^d AMCIS AG   (Switzerland)

Author keywords

Antitumor agents; Epothilones; Natural products; Stereoselectivity; Total synthesis

Indexed keywords

CYCLOPROPANE; EPOTHILONE A; EPOTHILONE B; EPOTHILONE DERIVATIVE; GLYCOPROTEIN P; GROWTH INHIBITOR;

ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CYCLOPROPANATION; DRUG ACTIVITY; DRUG MECHANISM; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STEREOCHEMISTRY; UTERINE CERVIX CARCINOMA;

EID: 33745329804     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-939727     Document Type: Article

References (32)

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