A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo

Diabetes

Volumn 55, Issue 5, 2006, Pages 1497-1503

  Kovacs, Peter ^a,b   Stumvoll, Michael ^b   Bogardus, Clifton ^a   Hanson, Robert L ^a   Baier, Leslie J ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

GEF, guanine nucleotide exchange factor; LARG, leukemia associated Rho guanine nucleotide exchange factor; LD, linkage disequilibrium; LPA, lysophosphatidic acid; PDZ, postsynaptic density disc large zo 1; SNP, single nucleotide polymorphism

Indexed keywords

CYSTEINE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INSULIN; PROTEIN LARG; TYROSINE; UNCLASSIFIED DRUG; ARHGEF12 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BASAL METABOLIC RATE; CHROMOSOME 11Q; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; GLUCOSE TRANSPORT; HUMAN; INDIAN; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PREVALENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; AMERICAN INDIAN; AMINO ACID SUBSTITUTION; ANIMAL; CELL STRAIN 3T3; CHROMOSOME 11; CHROMOSOME MAP; ETHNIC GROUP; GENETIC TRANSFECTION; GENETICS; LONGITUDINAL STUDY; PHYSIOLOGY; REFERENCE VALUE; SKELETAL MUSCLE; UNITED STATES;

3T3 CELLS; AMINO ACID SUBSTITUTION; ANIMALS; ARIZONA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; DIABETES MELLITUS, TYPE 2; ETHNIC GROUPS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INDIANS, NORTH AMERICAN; INSULIN; LONGITUDINAL STUDIES; MICE; MUSCLE, SKELETAL; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES; TRANSFECTION; VARIATION (GENETICS);

EID: 33745307425     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1331     Document Type: Article

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