메뉴 건너뛰기




Volumn 59, Issue 1, 2006, Pages 65-73

Antisense molecules for targeted cancer therapy

Author keywords

Antisense oligonucleotides; Apoptosis; Cell signaling; Clinical trials; RNA interference

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; CARBOPLATIN; CHOLESTEROL; CISPLATIN; CYCLODEXTRIN; CYTOTOXIC AGENT; DACARBAZINE; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; GEMCITABINE; GENE PRODUCT; ISIS 3521; LIPID; LIPOSOME; MACROGOL; OBLIMERSEN; OGX 11; PACLITAXEL; POLYMER; PROTAMINE; SHORT HAIRPIN RNA; SINGLE STRANDED DNA; SMALL INTERFERING RNA; TRANSFERRIN; UNCLASSIFIED DRUG; VIRUS VECTOR;

EID: 33745159389     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2005.10.004     Document Type: Review
Times cited : (49)

References (49)
  • 1
    • 0017670013 scopus 로고
    • Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation
    • Paterson B.M., Roberts B.E., and Kuff E.L. Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation. Proc Natl Acad Sci USA 74 (1977) 4370-4374
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 4370-4374
    • Paterson, B.M.1    Roberts, B.E.2    Kuff, E.L.3
  • 2
    • 0005772676 scopus 로고
    • Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide
    • Stephenson M.L., and Zamecnik P.C. Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. Proc Natl Acad Sci USA 75 (1978) 285-288
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 285-288
    • Stephenson, M.L.1    Zamecnik, P.C.2
  • 3
    • 0037146606 scopus 로고    scopus 로고
    • Breakthrough of the year. Small RNAs make big splash
    • Couzin J. Breakthrough of the year. Small RNAs make big splash. Science 298 (2002) 2296-2297
    • (2002) Science , vol.298 , pp. 2296-2297
    • Couzin, J.1
  • 4
    • 0001359591 scopus 로고
    • Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
    • Napoli C., Lemieux C., and Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2 (1990) 279-289
    • (1990) Plant Cell , vol.2 , pp. 279-289
    • Napoli, C.1    Lemieux, C.2    Jorgensen, R.3
  • 5
    • 0025405838 scopus 로고
    • Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression
    • van der Krol A.R., Mur L.A., Beld M., Mol J.N., and Stuitje A.R. Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell 2 (1990) 291-299
    • (1990) Plant Cell , vol.2 , pp. 291-299
    • van der Krol, A.R.1    Mur, L.A.2    Beld, M.3    Mol, J.N.4    Stuitje, A.R.5
  • 6
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 7
    • 4644336023 scopus 로고    scopus 로고
    • Revealing the world of RNA interference
    • Mello C.C., and Conte Jr. D. Revealing the world of RNA interference. Nature 431 (2004) 338-342
    • (2004) Nature , vol.431 , pp. 338-342
    • Mello, C.C.1    Conte Jr., D.2
  • 8
    • 0035925537 scopus 로고    scopus 로고
    • Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins
    • Gautschi O., Tschopp S., Olie R.A., et al. Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins. J Natl Cancer Inst 93 (2001) 463-471
    • (2001) J Natl Cancer Inst , vol.93 , pp. 463-471
    • Gautschi, O.1    Tschopp, S.2    Olie, R.A.3
  • 9
    • 20344371233 scopus 로고    scopus 로고
    • Antisense therapy for cancer
    • Gleave M.E., and Monia B.P. Antisense therapy for cancer. Nat Rev Cancer 5 (2005) 468-479
    • (2005) Nat Rev Cancer , vol.5 , pp. 468-479
    • Gleave, M.E.1    Monia, B.P.2
  • 10
    • 10044284093 scopus 로고    scopus 로고
    • Killing the messenger: antisense DNA and siRNA
    • Nesterova M., and Cho-Chung Y.S. Killing the messenger: antisense DNA and siRNA. Curr Drug Targets 5 (2004) 683-689
    • (2004) Curr Drug Targets , vol.5 , pp. 683-689
    • Nesterova, M.1    Cho-Chung, Y.S.2
  • 11
    • 0036846993 scopus 로고    scopus 로고
    • Antisense therapy for cancer-the time of truth
    • Jansen B., and Zangemeister-Wittke U. Antisense therapy for cancer-the time of truth. Lancet Oncol 3 (2002) 672-683
    • (2002) Lancet Oncol , vol.3 , pp. 672-683
    • Jansen, B.1    Zangemeister-Wittke, U.2
  • 12
    • 0036636074 scopus 로고    scopus 로고
    • Nucleic acid therapeutics: basic principles and recent applications
    • Opalinska J.B., and Gewirtz A.M. Nucleic acid therapeutics: basic principles and recent applications. Nat Rev Drug Discov 1 (2002) 503-514
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 503-514
    • Opalinska, J.B.1    Gewirtz, A.M.2
  • 13
    • 0018788204 scopus 로고
    • Site specific enzymatic cleavage of RNA
    • Donis-Keller H. Site specific enzymatic cleavage of RNA. Nucleic Acids Res 7 (1979) 179-192
    • (1979) Nucleic Acids Res , vol.7 , pp. 179-192
    • Donis-Keller, H.1
  • 14
    • 0030747101 scopus 로고    scopus 로고
    • A specificity comparison of four antisense types: morpholino, 2′-O-methyl RNA, DNA, and phosphorothioate DNA
    • Stein D., Foster E., Huang S.B., Weller D., and Summerton J. A specificity comparison of four antisense types: morpholino, 2′-O-methyl RNA, DNA, and phosphorothioate DNA. Antisense Nucleic Acid Drug Dev 7 (1997) 151-157
    • (1997) Antisense Nucleic Acid Drug Dev , vol.7 , pp. 151-157
    • Stein, D.1    Foster, E.2    Huang, S.B.3    Weller, D.4    Summerton, J.5
  • 15
    • 0027168725 scopus 로고
    • Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression
    • Monia B.P., Lesnik E.A., Gonzalez C., et al. Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression. J Biol Chem 268 (1993) 14514-14522
    • (1993) J Biol Chem , vol.268 , pp. 14514-14522
    • Monia, B.P.1    Lesnik, E.A.2    Gonzalez, C.3
  • 16
    • 0034938693 scopus 로고    scopus 로고
    • Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development
    • Orum H., and Wengel J. Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development. Curr Opin Mol Ther 3 (2001) 239-243
    • (2001) Curr Opin Mol Ther , vol.3 , pp. 239-243
    • Orum, H.1    Wengel, J.2
  • 17
    • 0033633241 scopus 로고    scopus 로고
    • Antisense properties of peptide nucleic acid
    • Nielsen P.E. Antisense properties of peptide nucleic acid. Methods Enzymol 313 (2000) 156-164
    • (2000) Methods Enzymol , vol.313 , pp. 156-164
    • Nielsen, P.E.1
  • 18
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E., Caudy A.A., Hammond S.M., and Hannon G.J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409 (2001) 363-366
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 19
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir S.M., Lendeckel W., and Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15 (2001) 188-200
    • (2001) Genes Dev , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 20
    • 2442495329 scopus 로고    scopus 로고
    • RISC is a 5′ phosphomonoester-producing RNA endonuclease
    • Martinez J., and Tuschl T. RISC is a 5′ phosphomonoester-producing RNA endonuclease. Genes Dev 18 (2004) 975-980
    • (2004) Genes Dev , vol.18 , pp. 975-980
    • Martinez, J.1    Tuschl, T.2
  • 21
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 22
    • 17144386185 scopus 로고    scopus 로고
    • Small interfering RNA for experimental cancer therapy
    • Tong A.W., Zhang Y.A., and Nemunaitis J. Small interfering RNA for experimental cancer therapy. Curr Opin Mol Ther 7 (2005) 114-124
    • (2005) Curr Opin Mol Ther , vol.7 , pp. 114-124
    • Tong, A.W.1    Zhang, Y.A.2    Nemunaitis, J.3
  • 23
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek J., Akinc A., Bramlage B., et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432 (2004) 173-178
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1    Akinc, A.2    Bramlage, B.3
  • 24
    • 0037197914 scopus 로고    scopus 로고
    • RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
    • Yu J.Y., DeRuiter S.L., and Turner D.L. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci USA 99 (2002) 6047-6052
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6047-6052
    • Yu, J.Y.1    DeRuiter, S.L.2    Turner, D.L.3
  • 26
    • 9144235839 scopus 로고    scopus 로고
    • High-throughput gene silencing using cell arrays
    • Vanhecke D., and Janitz M. High-throughput gene silencing using cell arrays. Oncogene 23 (2004) 8353-8358
    • (2004) Oncogene , vol.23 , pp. 8353-8358
    • Vanhecke, D.1    Janitz, M.2
  • 27
    • 24144463114 scopus 로고    scopus 로고
    • Progress in the delivery of therapeutic oligonucleotides: organ/cellular distribution and targeted delivery of oligonucleotides in vivo
    • Wang L., Prakash R.K., Stein C.A., Koehn R.K., and Ruffner D.E. Progress in the delivery of therapeutic oligonucleotides: organ/cellular distribution and targeted delivery of oligonucleotides in vivo. Antisense Nucleic Acid Drug Dev 13 (2003) 169-189
    • (2003) Antisense Nucleic Acid Drug Dev , vol.13 , pp. 169-189
    • Wang, L.1    Prakash, R.K.2    Stein, C.A.3    Koehn, R.K.4    Ruffner, D.E.5
  • 28
    • 0030460250 scopus 로고    scopus 로고
    • Retroviral targeted delivery
    • Schnierle B.S., and Groner B. Retroviral targeted delivery. Gene Ther 3 (1996) 1069-1073
    • (1996) Gene Ther , vol.3 , pp. 1069-1073
    • Schnierle, B.S.1    Groner, B.2
  • 29
    • 25444522673 scopus 로고    scopus 로고
    • Targeted gene delivery by intravenous injection of retroviral vectors
    • Morizono K., and Chen I.S. Targeted gene delivery by intravenous injection of retroviral vectors. Cell Cycle (2005) 4
    • (2005) Cell Cycle , pp. 4
    • Morizono, K.1    Chen, I.S.2
  • 30
    • 0023447252 scopus 로고
    • Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure
    • Felgner P.L., Gadek T.R., Holm M., et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84 (1987) 7413-7417
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7413-7417
    • Felgner, P.L.1    Gadek, T.R.2    Holm, M.3
  • 31
    • 0025891831 scopus 로고
    • Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells
    • Wagner E., Cotten M., Foisner R., and Birnstiel M.L. Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proc Natl Acad Sci USA 88 (1991) 4255-4259
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4255-4259
    • Wagner, E.1    Cotten, M.2    Foisner, R.3    Birnstiel, M.L.4
  • 32
    • 0034865914 scopus 로고    scopus 로고
    • Single-chain antibody-mediated gene delivery into ErbB2-positive human breast cancer cells
    • Li X., Stuckert P., Bosch I., Marks J.D., and Marasco W.A. Single-chain antibody-mediated gene delivery into ErbB2-positive human breast cancer cells. Cancer Gene Ther 8 (2001) 555-565
    • (2001) Cancer Gene Ther , vol.8 , pp. 555-565
    • Li, X.1    Stuckert, P.2    Bosch, I.3    Marks, J.D.4    Marasco, W.A.5
  • 33
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • Song E., Zhu P., Lee S.K., et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol 23 (2005) 709-717
    • (2005) Nat Biotechnol , vol.23 , pp. 709-717
    • Song, E.1    Zhu, P.2    Lee, S.K.3
  • 34
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: entering the mainstream
    • Allen T.M., and Cullis P.R. Drug delivery systems: entering the mainstream. Science 303 (2004) 1818-1822
    • (2004) Science , vol.303 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 35
    • 0028464351 scopus 로고
    • Strategies to achieve targeted gene delivery via the receptor-mediated endocytosis pathway
    • Michael S.I., and Curiel D.T. Strategies to achieve targeted gene delivery via the receptor-mediated endocytosis pathway. Gene Ther 1 (1994) 223-232
    • (1994) Gene Ther , vol.1 , pp. 223-232
    • Michael, S.I.1    Curiel, D.T.2
  • 36
    • 0036420573 scopus 로고    scopus 로고
    • Use of the post-insertion method for the formation of ligand-coupled liposomes
    • Allen T.M., Sapra P., and Moase E. Use of the post-insertion method for the formation of ligand-coupled liposomes. Cell Mol Biol Lett 7 (2002) 889-894
    • (2002) Cell Mol Biol Lett , vol.7 , pp. 889-894
    • Allen, T.M.1    Sapra, P.2    Moase, E.3
  • 38
    • 0242456160 scopus 로고    scopus 로고
    • The future of antisense therapy: combination with anticancer treatments
    • Biroccio A., Leonetti C., and Zupi G. The future of antisense therapy: combination with anticancer treatments. Oncogene 22 (2003) 6579-6588
    • (2003) Oncogene , vol.22 , pp. 6579-6588
    • Biroccio, A.1    Leonetti, C.2    Zupi, G.3
  • 39
    • 24944516000 scopus 로고    scopus 로고
    • RNA interference and potential therapeutic applications of short interfering RNAs
    • Karagiannis T.C., and El-Osta A. RNA interference and potential therapeutic applications of short interfering RNAs. Cancer Gene Ther (2005)
    • (2005) Cancer Gene Ther
    • Karagiannis, T.C.1    El-Osta, A.2
  • 40
    • 18344377018 scopus 로고    scopus 로고
    • Blocking cancer with RNA interference moves toward the clinic
    • Hede K. Blocking cancer with RNA interference moves toward the clinic. J Natl Cancer Inst 97 (2005) 626-628
    • (2005) J Natl Cancer Inst , vol.97 , pp. 626-628
    • Hede, K.1
  • 41
    • 23844475163 scopus 로고    scopus 로고
    • Long-term survival results of a randomized multinational phase 3 trial of dacarbazine (DTIC) with or without Bcl-2 antisense (oblimersen sodium) in patients (pts) with advanced malignant melanoma (MM)
    • Kirkwood J.M., Bedikian A.Y., Millward M.J., et al. Long-term survival results of a randomized multinational phase 3 trial of dacarbazine (DTIC) with or without Bcl-2 antisense (oblimersen sodium) in patients (pts) with advanced malignant melanoma (MM). Proc Am Soc Clin Oncol 24 (2005) 7506
    • (2005) Proc Am Soc Clin Oncol , vol.24 , pp. 7506
    • Kirkwood, J.M.1    Bedikian, A.Y.2    Millward, M.J.3
  • 42
    • 0242455819 scopus 로고    scopus 로고
    • Randomized phase III trial of chemotherapy and antisense oligonucleotide LY900003 (ISIS 3521) in patients with advanced NSCLC: initial report
    • Lynch Jr. T.J., Raju R., Lind M., et al. Randomized phase III trial of chemotherapy and antisense oligonucleotide LY900003 (ISIS 3521) in patients with advanced NSCLC: initial report. Proc Am Soc Clin Oncol 22 (2003) 623
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 623
    • Lynch Jr., T.J.1    Raju, R.2    Lind, M.3
  • 43
    • 0034684471 scopus 로고    scopus 로고
    • Chemosensitisation of malignant melanoma by BCL2 antisense therapy
    • Jansen B., Wacheck V., Heere-Ress E., et al. Chemosensitisation of malignant melanoma by BCL2 antisense therapy. Lancet 356 (2000) 1728-1733
    • (2000) Lancet , vol.356 , pp. 1728-1733
    • Jansen, B.1    Wacheck, V.2    Heere-Ress, E.3
  • 44
    • 4043108630 scopus 로고    scopus 로고
    • Randomized multinational phase 3 trial of dacarbazine (DTIC) with or without Bcl-2 antisense (oblimersen sodium) in patients (pts) with advanced malignant melanoma (MM): analysis of long-term survival
    • Millward M.J., Bedikian A.Y., Conry M., et al. Randomized multinational phase 3 trial of dacarbazine (DTIC) with or without Bcl-2 antisense (oblimersen sodium) in patients (pts) with advanced malignant melanoma (MM): analysis of long-term survival. Proc Am Soc Clin Oncol (2004) 7505
    • (2004) Proc Am Soc Clin Oncol , pp. 7505
    • Millward, M.J.1    Bedikian, A.Y.2    Conry, M.3
  • 45
    • 33745118474 scopus 로고    scopus 로고
    • Optimal oblimersen (G3139) sequence and schedule of administration when combined with docetaxel in the PC3 human prostate tumor model
    • Tolcher A., Mooberry S.L., Southwell T., Mangold G., and Rowinsky E.K. Optimal oblimersen (G3139) sequence and schedule of administration when combined with docetaxel in the PC3 human prostate tumor model. Proc Am Assoc Cancer Res (2003) #2755
    • (2003) Proc Am Assoc Cancer Res
    • Tolcher, A.1    Mooberry, S.L.2    Southwell, T.3    Mangold, G.4    Rowinsky, E.K.5
  • 46
    • 11144282529 scopus 로고    scopus 로고
    • Role of toll-like receptors in antisense and siRNA [corrected]
    • Agrawal S., and Kandimalla E.R. Role of toll-like receptors in antisense and siRNA [corrected]. Nat Biotechnol 22 (2004) 1533-1537
    • (2004) Nat Biotechnol , vol.22 , pp. 1533-1537
    • Agrawal, S.1    Kandimalla, E.R.2
  • 47
    • 0037685280 scopus 로고    scopus 로고
    • Expression profiling reveals off-target gene regulation by RNAi
    • Jackson A.L., Bartz S.R., Schelter J., et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 21 (2003) 635-637
    • (2003) Nat Biotechnol , vol.21 , pp. 635-637
    • Jackson, A.L.1    Bartz, S.R.2    Schelter, J.3
  • 48
    • 24744470522 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer
    • Chi K.N., Eisenhauer E., Fazli L., et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst 97 (2005) 1287-1296
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1287-1296
    • Chi, K.N.1    Eisenhauer, E.2    Fazli, L.3
  • 49
    • 6344260319 scopus 로고    scopus 로고
    • Strategies for designing clinical trials for oligonucleotide therapeutics
    • Wacheck V. Strategies for designing clinical trials for oligonucleotide therapeutics. Drug Discov Today 9 (2004) 918-923
    • (2004) Drug Discov Today , vol.9 , pp. 918-923
    • Wacheck, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.