Tighter binding of HIV reverse transcriptase to RNA-DNA versus DNA-DNA results mostly from interactions in the polymerase domain and requires just a small stretch of RNA-DNA

Biochemistry

Volumn 45, Issue 24, 2006, Pages 7628-7638

  Bohlayer, William P ^a   DeStefano, Jeffrey J ^a  

^a Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISSOCIATION; DNA; ENZYME KINETICS; MOLECULAR ORIENTATION; REACTION KINETICS; RNA;

POLYMERASE; REVERSE ORIENTATION; TEMPLATE STRANDS; TRANSCRIPTASE;

ENZYMES;

DNA; NUCLEIC ACID; NUCLEOTIDE; PRIMER DNA; RIBONUCLEASE H; RNA; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ARTICLE; BASE PAIRING; DISSOCIATION CONSTANT; DNA DNA HYBRIDIZATION; DNA RNA HYBRIDIZATION; DRUG DEVELOPMENT; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

BASE SEQUENCE; BINDING SITES; DNA; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; NUCLEIC ACID HETERODUPLEXES; PROTEIN STRUCTURE, TERTIARY; RNA; SUBSTRATE SPECIFICITY; TEMPLATES, GENETIC;

EID: 33745143570     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051770w     Document Type: Article

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