Aptamers directed to HIV-1 reverse transcriptase display greater efficacy over small hairpin RNAs targeted to viral RNA in blocking HIV-1 replication

Molecular Therapy

Volumn 11, Issue 5, 2005, Pages 677-686

  Joshi, Pheroze J ^a   North, Thomas W ^b   Prasad, Vinayaka R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; GREEN FLUORESCENT PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; RETROVIRUS VECTOR; RIBONUCLEASE; RNA DIRECTED DNA POLYMERASE; SHORT HAIRPIN RNA; VIRUS RNA;

ARTICLE; CELL SELECTION; GENE EXPRESSION; GENE TARGETING; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PROMOTER REGION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; STEADY STATE; T LYMPHOCYTE; TARGET CELL; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRION; VIRUS INHIBITION; VIRUS REPLICATION;

BASE PAIRING; CELL LINE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; PROMOTER REGIONS (GENETICS); RNA; RNA, SMALL NUCLEAR; RNA, VIRAL; TIME FACTORS; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 17644395235     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.01.013     Document Type: Article

References (31)

1. P.J. Joshi T.S. Fisher and V.R. Prasad Anti-HIV inhibitors based on nucleic acids: Emergence of aptamers as potent antivirals Curr. Drug Targets Infect. Disord. 3 2003 383-400
2. D.H. Burke L. Scates K. Andrews and L. Gold Bent pseudoknots and novel RNA inhibitors of type 1 human immunodeficiency virus (HIV-1) reverse transcriptase J. Mol. Biol. 264 1996 650-666
3. P. Joshi and V.R. Prasad Potent inhibition of human immunodeficiency virus type 1 replication by template analog reverse transcriptase inhibitors derived by SELEX (systematic evolution of ligands by exponential enrichment) J. Virol. 76 2002 6545-6557
4. N.S. Lee et al., Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells Nat. Biotechnol. 20 2002 500-505
5. C.D. Novina et al., siRNA-directed inhibition of HIV-1 infection Nat. Med. 8 2002 681-686
6. J.M. Jacque K. Triques and M. Stevenson Modulation of HIV-1 replication by RNA interference Nature 418 2002 435-438
7. G.A. Coburn and B.R. Cullen Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference J. Virol. 76 2002 9225-9231
8. R.M. Surabhi and R.B. Gaynor RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication J. Virol. 76 2002 12963-12973
9. G.J. Hannon and J.J. Rossi Unlocking the potential of the human genome with RNA interference Nature 431 2004 371-378
10. H. Kawasaki and K. Taira Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells Nucleic Acids Res. 31 2003 700-707
11. M.J. Li et al., Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs Mol. Ther. 8 2003 196-206
12. C.P. Paul P.D. Good S.X. Li A. Kleihauer J.J. Rossi and D.R. Engelke Localized expression of small RNA inhibitors in human cells Mol. Ther. 7 2003 237-247
13. D. Boden O. Pusch F. Lee L. Tucker P.R. Shank and B. Ramratnam Promoter choice affects the potency of HIV-1 specific RNA interference Nucleic Acids Res. 31 2003 5033-5038
14. I. Riviere K. Brose and R.C. Mulligan Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells Proc. Natl. Acad. Sci. USA 92 1995 6733-6737
15. M. Rosenzweig et al., Induction of cytotoxic T lymphocyte and antibody responses to enhanced green fluorescent protein following transplantation of transduced CD34(+) hematopoietic cells Blood 97 2001 1951-1959
16. N.S. Lee and J.J. Rossi Control of HIV-1 replication by RNA interference Virus Res. 102 2004 53-58
17. W.Y. Hu F.D. Bushman and A.C. Siva RNA interference against retroviruses Virus Res. 102 2004 59-64
18. K. Uberla et al., Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors Proc. Natl. Acad. Sci. USA 92 1995 8210-8214
19. + progenitor cell-derived macrophages Mol. Ther. 8 2003 62-71
20. A. Fassati and S.P. Goff Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1 J. Virol. 75 2001 3626-3635
21. M.I. Bukrinsky N. Sharova T.L. McDonald T. Pushkarskaya W.G. Tarpley and M. Stevenson Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection Proc. Natl. Acad. Sci. USA 90 1993 6125-6129
22. M. Stevenson Dissecting HIV-1 through RNA interference Nat. Rev. Immunol. 3 2003 851-858
23. A.T. Das et al., Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition J. Virol. 78 2004 2601-2605
24. T.S. Fisher P. Joshi and V.R. Prasad Mutations that confer resistance to template-analog inhibitors of human immunodeficiency virus (HIV) type 1 reverse transcriptase lead to severe defects in HIV replication J. Virol. 76 2002 4068-4072
25. D. Castanotto H. Li and J.J. Rossi Functional siRNA expression from transfected PCR products Rna 8 2002 1454-1460
26. J.W. Roos M.F. Maughan Z. Liao J.E. Hildreth and J.E. Clements LuSIV cells: A reporter cell line for the detection and quantitation of a single cycle of HIV and SIV replication Virology 273 2000 307-315
27. A.C. Giuffre J. Higgins R.W. Buckheit Jr. and T.W. North Susceptibilities of simian immunodeficiency virus to protease inhibitors Antimicrob. Agents Chemother. 47 2003 1756-1759
28. J.P. Murry et al., Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine J. Virol. 77 2003 1120-1130
29. K. Soderberg L. Denekamp S. Nikiforow K. Sautter R.C. Desrosiers and L. Alexander A nucleotide substitution in the tRNA(Lys) primer binding site dramatically increases replication of recombinant simian immunodeficiency virus containing a human immunodeficiency virus type 1 reverse transcriptase J. Virol. 76 2002 5803-5806
30. J.G. Julias A.L. Ferris P.L. Boyer and S.H. Hughes Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase J. Virol. 75 2001 6537-6546
31. S.L. Butler M.S. Hansen and F.D. Bushman A quantitative assay for HIV DNA integration in vivo Nat. Med. 7 2001 631-634