Epigenetic inactivation implies a tumor suppressor function in hematologic malignancies for polo-like kinase 2 but not polo-like kinase 3

Cell Cycle

Volumn 5, Issue 12, 2006, Pages 1262-1264

  Smith, Paul ^a   Syed, Nelofer ^a   Crook, Tim ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Methylation; Polo like kinases; Transcriptional silencing; Tumor suppressor gene

Indexed keywords

DOCETAXEL; PACLITAXEL; POLO LIKE KINASE 2; POLO LIKE KINASE 3; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; B CELL LYMPHOMA; CANCER INHIBITION; CELL CYCLE; CELL CYCLE G2 PHASE; CPG ISLAND; DNA DAMAGE; EPIGENETICS; GENE INACTIVATION; GENE OVEREXPRESSION; GENE TARGETING; HEMATOLOGIC MALIGNANCY; METHYLATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHORT SURVEY; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

EID: 33745140916     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.12.2813     Document Type: Short Survey

References (19)

1. Van de Weerdt BCM, Medema RH. Polo-like kinases: A team in control of the division. Cell Cycle 2006; 5:1-12.
2. Fenton B, Glover DM. A conserved mitotic kinase active at late anaphase-telophase in syncitial Drosophila embryos. Nature 1993; 363:637-640.
3. Nigg EA. Polo-like kinases: Positive regulators of cell division from start to finish. Curr Opin Cell Biol 2004; 10:776-83.
4. Simmons DL, Neel BG, Stevens R, Evett G, Erikson L. Identification of an early growth-response gene encoding a novel putative serine/threonine kinase. Mol Cell Biol 1992; 12:4164-9.
5. Donohue PJ, Alberts GF, Guo Y, Winkles JA. Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J Biol Chem 270:10351-7.
6. Syed N, Smith P, Sullivan A, Spender LC, Dyer M, Karran L, O'Nions J, Allday M, Hoffmann I, Crawford D, Griffin B, Farrell PJ, Crook T. Transcriptional silencing of Polo-like kinase 2 (Snk/Plk2) is a frequent event in B-cell malignancies. Blood 2006; 107:250-6.
7. Warnke S, Kemmler S, Hames R, Tsai HL, Hoffmann-Rohrer U, Fry Am, Hoffman I. Polo-like kinase-2 is required for centriole duplication in mammalian cells. Current Biol 2004; 14:1200-7.
8. Hoffman I. Playing polo in G1: A novel function of polo like kinase 2 in centriole duplication. Cell Cycle 2004; 3:76-7.
9. Ma S, Charron J, Erikson R. Role of Plk2 (Snk) in mouse development and cell proliferation. Mol Cell Biol 2003; 23:6936-43.
10. Jiang N, Wang X, Jhanwar-Uniyal M, Darzynkiewicz Z, Dai W. Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects and apoptosis. J Biol Chem 2006; 281:10577-82.
11. Habedanck R, Stierhof YD, Wilkinson CJ, Nigg EA. The Polo kinase Plk4 functions in centriole duplication. Nature Cell Biology 2005; 7:1140-6.
12. Yogosawa S, Hatakeyama S, Nakayama KI, Miyoshi H, Kohsaka S, Akazawa C. Ubiquitylation and degradation of polo-like kinase SNK by hVPS18, a RING-E2 type ubiquitin ligase. J Biol Chem 2005; 280:41619-27.
13. Winkles JA, Alberts GF. Differential regulation of polo-like kinase 1, 2, 3 and 4 gene expression in mammalian cells and tissues. Oncogene 2005; 24:260-6.
14. 2 to M transition. J Cell Biol 2002; 156:249-59.
15. Burns TF, Fei P, Scata KA, Dicker DT, El-Deiry WS. Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (Taxol)-exposed cells. Mol Cell Biol 2003; 23:5556-71.
16. 2/M progression. Mol Cell 1997; 1:3-11.
17. INK4a is an early event in vulval squamous neoplasia. Oncogene 2002; 21:1876-81.
18. INK4a silencing and human papillomavirus negativity. Cancer Res 2002; 62:2072-6.
19. Wang Q, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W. Cell cycle arrest and apoptosis induced by human polo-like kinase 3 is mediated through perturbation of microtubule integrity. Mol Cell Biol 2002; 22:3450-9.