The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV-1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load

Journal of Neurochemistry

Volumn 98, Issue 1, 2006, Pages 146-155

  Caporello, Emily ^a   Nath, Avindra ^a   Slevin, John ^b   Galey, David ^a   Hamilton, Greg ^c   Williams, Larry ^c   Steiner, Joseph P ^a   Haughey, Norman J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^c GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Calcium; gp120; GPI1046; Inositol 1,4,5 trisphosphate; Ryanodine; Tat

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; CALCIUM; GLYCOPROTEIN GP 120; GPI 1334; IMMUNOPHILIN; INOSITOL 1,4,5 TRISPHOSPHATE; RYANODINE; TACROLIMUS; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; HUMAN IMMUNODEFICIENCY VIRUS 1; INCUBATION TIME; LETHALITY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RODENT;

ANIMALS; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DRUG INTERACTIONS; EMBRYO; ENDOPLASMIC RETICULUM; GENE PRODUCTS, TAT; HIV ENVELOPE PROTEIN GP120; NEURONS; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33745101399     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03863.x     Document Type: Article

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