gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors

Journal of Neurochemistry

Volumn 74, Issue 6, 2000, Pages 2373-2379

  Valeria Catani, M ^a   Tiziana Corasaniti, M ^d   Navarra, Michele ^d   Nisticò, Giuseppe ^c   Finazzi Agrò, Alessandro ^b   Melino, Gerry ^a,c  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^b Department of Experimental Medicine ^*  (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

CCR5; Chemokines; CXCR4; HIV 1 gp120; NMDA receptor

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; VIRUS GLYCOPROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL DEATH; CYTOTOXICITY; DEMENTIA; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TARGET CELL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTIBODIES, MONOCLONAL; CELL DEATH; FLOW CYTOMETRY; GENE EXPRESSION; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MACROPHAGE INFLAMMATORY PROTEIN-1; NEUROBLASTOMA; NEURONS; PROTEIN BINDING; RANTES; RECEPTORS, CCR5; RECEPTORS, CXCR4; RECEPTORS, N-METHYL-D-ASPARTATE; TUMOR CELLS, CULTURED;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0343238355     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0742373.x     Document Type: Article

References (51)

1. Ameisen J. C., Estaquier J., Idziorek T., and De Bels F. (1995) Programmed cell death and AIDS: significance, perspectives and unanswered questions. Cell Death Differ. 2, 9-22.
2. Barks J. D., Liu X. H., Sun R., and Silverstein F. S. (1997) gp120, a human immunodeficiency virus-1 coat protein, augments excitotoxic hippocampal injury in perinatal rats. Neuroscience 76, 397-409.
3. Bleul C. C., Farzan M., Choe H., Parolin C., Clark-Lewis I., Sodroski J., and Springer T. A. (1996) The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382, 829-835.
4. Brenneman D. E., McCune S. K., Mervis R. F., and Hill J. M. (1994) gp120 as an etiologic agent for neuroAIDS: neurotoxicity and model systems. Adv. Neuroimmunol. 4, 157-165.
5. Brooke S., Chan R., Howard S., and Sapolsky R. (1997) Endocrine modulation of the neurotoxicity of gp120: implications for AIDS-related dementia complex. Proc. Natl. Acad. Sci. USA 94, 9457-9462.
6. Buzy J., Brenneman D. E., Pert C. B., Martin A., Salazar A., and Ruff M. R. (1992) Potent gp120-like neurotoxic activity in the cerebrospinal fluid of HIV-infected individuals is blocked by peptide T. Brain Res. 598, 10-18.
7. Choe H., Martin K. A., Farzan M., Sodroski J., Gerard N. P., and Gerard C. (1998) Structural interactions between chemokine receptors, gp120 Env and CD4. Semin. Immunol. 10, 249-257.
8. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
9. + T cells. Science 270, 1811-1815.
10. Corasaniti M. T., Melino G., Navarra M., Garaci E., Finazzi-Agrò A., and Nisticò G. (1995) Death of cultured neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. Neurodegeneration 4, 315-321.
11. Corasaniti M. T., Navarra M., Catani M. V., Melino G., Nisticò G., and Finazzi-Agrò A. (1996) NMDA and HIV-1 coat protein, gp120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain. Biochem. Biophys. Res. Commun. 229, 299-304.
12. Davis C. B., Dikic I., Unutmaz D., Hill C. M., Arthos J., Siani M. A., Thompson D. A., Schlessinger J., and Littman D. R. (1997) Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J. Exp. Med. 186, 1793-1798.
13. Deng H., Liu R., Ellmeier W., Choe S., Unutmaz D., Burkhart M., Di Marzio P., Marmon S., Sutton R. E., Hill C. M., Davis C. B., Peiper S. C., Schall T. J., Littman D. R., and Landau N. R. (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666.
14. + cells is mediated by the chemokine receptor CC-CKR5. Nature 381, 667-673.
15. Edinger A. L., Mankowski J. L., Doranz B. J., Margulies B. J., Lee B., Rucker J., Sharron M., Hoffman T. L., Berson J. F., Zink M. C., Hirsch V. M., Clements J. E., and Doms R. W. (1997) CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain. Proc. Natl. Acad. Sci. USA 94, 14742-14747.
16. Endres M. J., Clapham P. R., Marsh M., Ahuja M., Turner J. D., McKnight A., Thomas J. F., Stoebenau-Haggarty B. S., Choe P. J. V., Wells T. N. C., Power C. A., Sutterwala S. S., Doms R. W., Landau N. R., and Hoxie J. A. (1996) CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell 87, 745-756.
17. Everall I. P., Luthert P. J., and Lantos P. L. (1991) Neuronal loss in the frontal cortex in HIV infection. Lancet 337, 1119-1121.
18. Feng Y., Broder C. C., Kennedy P. E., and Berger E. A. (1996) HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272, 872-877.
19. Gelbard H. A., Nottet H. S., Swindells S., Jett M., Dzenko K. A., Genis P., White R., Wang L., Choi Y. B., Zhang D., Lipton S. A., Tourtellotte W. W., Epstein L. G., and Gendelman H. E. (1994) Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J. Virol. 68, 4628-1635.
20. Genis P., Jett M., Bernton E. W., Boyle T., Gelbard H. A., Dzenko K., Keane R. W., Resnick L., Mizrachi Y., Volsky D. J., Epstein L. G., and Gendelman H. E. (1992) Cytokines and arachidonic acid metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J. Exp. Med. 176, 1703-1718.
21. Giulian D., Wendt E., Vaca K., and Noonan C. A. (1993) The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes. Proc. Natl Acad. Sci. USA 90, 2769-2773.
22. Golding H., Manischewitz J., Vujcic L., Blumenthal R., and Dimitrov D. S. (1994) The phorbol ester phorbol myristate acetate inhibits type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells. J. Virol. 68, 1962-1969.
23. Golding H., Dimitrov D. S., Manischewitz J., Broder C. C., Robinson J., Fabian S., Littman D. R., and Lapham C. K. (1995) Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules. J. Virol. 69, 6140-6148.
24. He J., Chen Y., Farzan M., Choe H., Ohagen A., Gartner S., Busciglio J., Yang X., Hofmann W., Newman W., Mackay C. R., Sodroski J., and Gabuzda D. (1997) CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385, 645-649.
25. Hesselgesser J., Halks-Miller M., DelVecchio V., Peiper S. C. Hoxie J., Kolson D. L., Taub D., and Horuk R. (1997) CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurones. Curr. Biol. 7, 112-121.
26. Hesselgesser J., Taub D., Baskar P., Greenberg M., Hoxie J., Kolson D. L., and Horuk R. (1998) Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4. Curr. Biol. 8, 595-598.
27. Janssen R. S., Cornblath D. R., Epstein L. G., Foa R. P., McArthur J. C., and Price R. W. (1991) Nomenclature and research case definitions for neurological manifestations of human immunodeficiency virus type-1 (HIV-1) infection. Neurology 41, 778-785.
28. Ketzler S., Weid S., Haug H., and Budka H. (1990) Loss of neurones in the frontal cortex in AIDS brains. Lancet 337, 1119-1121.
29. i homeostasis and induce neurotoxicity in human embryonic neurones. Eur. J. Neurosci. 7, 2285-2293.
30. Lapham C. K., Ouyang J., Chandrasekhar B., Nguyen N. Y., Dimitrov D. S., and Golding H. (1996) Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. Science 274, 602-605.
31. Lavi E., Strizki J. M., Ulrich A. M., Zhang W., Fu L., Wang Q., O'Connor M., Hoxie J. A., and Gonzalez-Scarano F. (1997) CXCR-4 (fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurones. Am. J. Pathol. 151, 1035-1042.
32. Lavi E., Kolson D. L., Ulrich A. M. Fu L., and Gonzalez-Scarano F. (1998) Chemokine receptors in the human brain and their relationship to HIV infection. J. Neurovirol. 4, 301-311.
33. Lipton S. A. (1992a) Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuroreport 3, 913-915.
34. Lipton S. A. (1992b) Models of neuronal injury in AIDS: another role for the NMDA receptors? Trends Neurosci. 15, 75-79.
35. Lipton S. A. and Gendelman H. E. (1995) Dementia associated with the acquired immunodeficiency syndrome. N. Engl. J. Med. 332, 934-940.
36. Lipton S. A., Sucher N. J., Kaiser P. K., and Dreyer E. B. (1991) Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 7, 111-118.
37. McArthur J. C., Hoover D. R., Bacellar H., Miller E. N., Cohen B. A., Becker J. T., Graham N. M. H., McArthur J. H., Selnes O. A., Jacobson L. P., Visscher B. R., Concha M., and Saah A. (1993) Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study. Neurology 43, 2245-2252.
38. Meucci O., Fatatis A., Simen A. A., Buschell T. J., Gray T. W., and Miller R. J. (1998) Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc. Natl. Acad. Sci. USA 95, 14500-14505.
39. Moncada F., Palmer R. M. J., and Higgs E. A. (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43, 623-634.
40. Pattarini R., Pittaluga A., and Raiteri M. (1998) The human immunodeficiency virus-1 envelope protein gp120 binds through its V3 sequence to the glycine site of N-methyl-D-aspartate receptors mediating noradrenaline release in the hippocampus. Neuroscience 87, 147-157.
41. Premack B. A. and Schall T. J. (1996) Chemokine receptors: gateways to inflammation and infection. Nat. Med. 2, 1174-1178.
42. Price R. W., Brew B., Sidtis J., Rosenblum M., Scheck A. C., and Cleary P. (1988) The brain and AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 239, 586-592.
43. Reeves J. D., Heveker N., Brelot A., Alizon M., Clapham P. R., and Picard L. (1998) The second extracellular loop of CXCR4 is involved in CD4-independent entry of human immunodeficiency virus type 2. J. Gen. Virol. 79, 1793-1799.
44. Rizzuto C. D., Wyatt R., Hernandez-Ramos N., Sun Y., Kwong P. D., Hendrickson W. A., and Sodroski J. (1998) A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280, 1949-1953.
45. Sanders V. J., Pittman C. A., White M. G., Wang G., Wiley C. A., and Achim C. L. (1998) Chemokines and receptors in HIV encephalitis. AIDS 12, 1021-1026.
46. Savio T. and Levi G. (1993) Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: a study with rat cerebellar granule cell cultures. J. Neurosci. Res. 34, 265-272.
47. Shieh J. T. C. Albright A. V., Sharron M., Gartner S., Strizki J., Doms R. W., and Gonzalez-Scarano F. (1998) Chemokine receptor utilization by human immunodeficiency virus type 1 isolates that replicate in microglia. J. Virol. 72, 4243-4249.
48. Vallat A.-V., De Girolami U., He J., Mhashilkar A., Marasco W., Shi B., Gray F., Bell J., Keohane C., Smith T. W., and Gabuzda D. (1998) Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS. Am. J. Pathol. 152, 167-178.
49. Vesce S., Bezzi P., Rossi D., Meldolesi J., and Volterra A. (1997) HIV-1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid. FEBS Lett. 411, 107-109.
50. Weissman D., Rabin R. L., Arthos J., Rubbert A., Dybul M., Swofford R., Venkatesan S., Farber J. M., and Fauci A. S. (1997) Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389, 981-985.
51. Wu L., Gerard N. P., Wyatt R., Choe H., Parolin C., Ruffing N., Borsetti A., Cardoso A. A., Desjardin E., Newman W., Gerard C., and Sodroski J. (1996) CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature 384, 179-183.