Enhancement of NKT Cells and Increase in Regulatory T Cells Results in Improved Allograft Survival

Journal of Surgical Research

Volumn 134, Issue 1, 2006, Pages 10-21

  Li, Wei ^a   Carper, Katie ^a   Perkins, James D ^a  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

CD25+CD4+ T cell; cytokines; FK506; graft survival; heart transplantation; liver non parenchymal cells; NKT cell; oral tolerance; spleen cells

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TACROLIMUS;

ACUTE GRAFT REJECTION; ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CARDIAC GRAFT REJECTION; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART GRAFT; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; IMMUNOMODULATION; IMMUNOREGULATION; LIVER; MALE; MOUSE; MOUSE STRAIN; NATURAL KILLER T CELL; NONHUMAN; PREOPERATIVE CARE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN; SPLEEN CELL; STATISTICAL SIGNIFICANCE; SURVIVAL TIME; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION TOLERANCE;

ANIMALS; APOPTOSIS; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED STRAINS; T-LYMPHOCYTES, REGULATORY; TACROLIMUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 33744989657     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2006.03.025     Document Type: Article

References (62)

1. Weiner H.L., Friedman A., Miller A., et al. Oral tolerance. Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 12 (1994) 809
2. Li W., Chou S.T., Wang C., Kuhr C.S., and Perkins J.D. Role of the liver in peripheral tolerance. Induction through oral antigen feeding. Am J Transplant 4 (2004) 1574
3. Trop S., Samsonov D., Gotsman I., Alper R., Diment J., and Ilan Y. Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model. Hepatology 29 (1999) 746
4. Zavazava N., Fandrich F., Zhu X., Freese A., Behrens D., and Yoo-Ott K.A. Oral feeding of an immunodominant MHC donor-derived synthetic class I peptide prolongs graft survival of heterotopic cardiac allografts in a high-responder rat strain combination. J Leukoc Biol 67 (2000) 793
5. Niimi M., Ikeda Y., Kan S., Shirasugi N., and Hamano K. Indefinite survival of fully allogeneic cardiac grafts induced by antigen delivery through the alimentary tract. J Thorac Cardiovasc Surg 122 (2001) 629
6. Niimi M., Witzke O., Bushell A., Hara M., Morris P.J., and Wood K.J. Nondepleting anti-CD4 monoclonal antibody enhances the ability of oral alloantigen delivery to induce indefinite survival of cardiac allografts. Oral tolerance to alloantigen. Transplantation 70 (2000) 1524
7. +) T cells are required for oral and portal venous tolerance induction. J Surg Res 104 (2002) 29
8. Trentham D.E., Dynesius-Trentham R.A., Orav E.J., et al. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 261 (1993) 1727
9. Weiner H.L., Mackin G.A., Matsui M., et al. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 259 (1993) 1321
10. Samsonov D., Trop S., Alper R., Diment J., and Ilan Y. Enhancement of immune tolerance via induction of NK1.1 positive liver-associated-lymphocytes under immunosuppressive conditions. J Hepatol 32 (2000) 812
11. Geissmann F., Cameron T.O., Sidobre S., et al. Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol Epub 3 (2005) e113
12. Bendelac A., Rivera M.N., Park S.H., and Roark J.H. Mouse CD1-specific NK1 T cells. Development, specificity, and function. Annu Rev Immunol 15 (1997) 535
13. Seino K.I., Fukao K., Muramoto K., et al. K. Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc Natl Acad Sci USA 98 (2001) 2577
14. Ono K., and Lindsey E.S. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 57 (1969) 225
15. Li W., Fu F., Lu L., Narula S.K., Fung J.J., Thomson A.W., and Qian S. Differential effects of exogenous interleukin-10 on cardiac allograft survival. Inhibition of rejection by recipient pretreatment reflects impaired host accessory cell function. Transplantation 68 (1999) 1402
16. Duthie M.S., Wleklinski-Lee M., Smith S., Nakayama T., Taniguchi M., and Kahn S.J. During Trypanosoma cruzi infection CD1d-restricted NKT cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein. Infect Immun 70 (2002) 36
17. Li W., Zheng X.X., Kuhr C.S., and Perkins J.D. CTLA4 engagement is required for induction of murine liver transplant spontaneous tolerance. Am J Transplant 5 (2005) 978
18. Gavrieli Y., Sherman Y., and Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119 (1992) 493
19. Kawano T., Cui J., Koezuka Y., et al. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278 (1997) 1626
20. Li W., Lu L., Wang Z., Wang L., Fung J.J., Thomson A.W., and Qian S. Costimulation blockade promotes the apoptotic death of graft-infiltrating T cells and prolongs survival of hepatic allografts from FLT3L-treated donors. Transplantation 72 (2001) 1423
21. Li W., Lu L., Wang Z., Wang L., Fung J.J., Thomson A.W., and Qian S. IL-12 antagonism enhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-treated donors and promotes graft acceptance. J Immunol 166 (2001) 5619
22. Lu L., Li W., Zhong C., et al. Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb. Transplantation 68 (1999) 747
23. Godfrey D.I., and Kronenberg M. Going both ways. Immune regulation via CD1d-dependent NKT cells. J Clin Invest 114 (2004) 1379
24. Hansen D.S., and Schofield L. Regulation of immunity and pathogenesis in infectious diseases by CD1d-restricted NKT cells. Int J Parasitol 34 (2004) 15
25. Godfrey D.I., Hammond K.J., Poulton L.D., Smyth M.J., and Baxter A.G. NKT cells. Facts, functions and fallacies. Immunol Today 21 (2000) 573
26. van der Vliet H.J., Molling J.W., von Blomberg B.M., et al. The immunoregulatory role of CD1d-restricted natural killer T cells in disease. Clin Immunol 112 (2004) 8
27. Taniguchi M., Harada M., Kojo S., Nakayama T., and Wakao H. The regulatory role of Vα14 NKT cells in innate and acquired immune response. Annu Rev Immunol 21 (2003) 483
28. Brossay L., Chioda M., Burdin N., et al. CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J Exp Med 188 (1998) 1521
29. Emoto M., and Kaufmann S.H. Liver NKT cells. An account of heterogeneity. Trends Immunol 24 (2003) 364
30. Eberl G., Lees R., Smiley S.T., Taniguchi M., Grusby M.J., and MacDonald H.R. Tissue-specific segregation of CD1d-dependent and CD1d-independent NKT cells. J Immunol 162 (1999) 6410
31. + Vα14 natural killer T cells are essential for acceptance of rat islet xenografts in mice. J Clin Invest 105 (2000) 1761
32. Liu R., La Cava A., Bai X.F., et al. Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia. J Immunol 175 (2005) 7898
33. + T cells lose NK1.1 expression upon in vitro activation. J Immunol 158 (1997) 5112
34. Crowe N.Y., Uldrich A.P., Kyparissoudis K., et al. Glycolipid antigen drives rapid expansion and sustained cytokine production by NKT cells. J Immunol 171 (2003) 4020
35. Sonoda K.H., Exley M., Snapper S., Balk S.P., and Stein-Streilein J. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp Med 190 (1999) 1215
36. Sonoda K.H., Taniguchi M., and Stein-Streilein J. Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells. J Immunol 168 (2002) 2028
37. + T cells to the spleen during the generation of regulatory T cells in tolerance. J Immunol 169 (2002) 31
38. Makino Y., Yamagata N., Sasho T., et al. Extrathymic development of Vα14-positive T cells. J Exp Med 177 (1993) 1399
39. Leite-De-Moraes M.C., Moreau G., Arnould A., et al. IL-4-producing NK T cells are biased towards IFN-γ production by IL-12. Influence of the microenvironment on the functional capacities of NK T cells. Eur J Immunol 28 (1998) 1507
40. Zipperle S., Weimer R., Golling M., Daniel V., Otto G., and Opelz G. Impaired T-cell IL-10 secretion and CD4 helper function in liver transplant patients treated with tacrolimus. Transplant Proc 29 (1997) 1079
41. Jiang S., Game D.S., Davies D., Lombardi G., and Lechler R.I. Activated CD1d-restricted natural killer T cells secrete IL-2. Innate help for CD4+CD25+ regulatory T cells?. Eur J Immunol 35 (2005) 1193
42. Matsuda J.L., Gapin L., Baron J.L., et al. Mouse Vα14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci USA 100 (2003) 8395
43. Weiner H.L. Oral tolerance. Immune mechanisms and treatment of autoimmune diseases. Immunol Today 18 (1997) 335
44. Mowat A.M. The regulation of immune responses to dietary protein antigens. Immunol Today 8 (1987) 93
45. Garside P., and Mowat A.M. Mechanisms of oral tolerance. Crit Rev Immunol 17 (1997) 119
46. h1 cells. Gastroenterology 116 (1999) 1428
47. + Th2 cells via apoptosis. Hepatology 38 (2003) 403
48. Tokita D., Ohdan H., Onoe T., Hara H., Tanaka Y., and Asahara T. Liver sinusoidal endothelial cells contribute to alloreactive T-cell tolerance induced by portal venous injection of donor splenocytes. Transpl Int 18 (2005) 237
49. Kawano T., Cui J., Koezuka Y., et al. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells. Proc Natl Acad Sci USA 95 (1998) 5690
50. + invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells. J Immunol 173 (2004) 1043
51. Novak J., Beaudoin L., Griseri T., and Lehuen A. Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts. J Immunol 174 (2005) 1954
52. Leite-De-Moraes M.C., Hameg A., Arnould A., et al. A distinct IL-18-induced pathway to fully activate NK T lymphocytes independently from TCR engagement. J Immunol 163 (1999) 5871
53. Shimizu H., Matsuguchi T., Fukuda Y., et al. Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice. Gastroenterology 123 (2002) 1265
54. Brunner T., Yoo N.J., Griffith T.S., Ferguson T.A., and Green D.R. Regulation of CD95 ligand expression. A key element in immune regulation?. Behring Inst Mitt 97 (1996) 161
55. Gao Y., Herndon J.M., Zhang H., Griffith T.S., and Ferguson T.A. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis. J Exp Med 188 (1998) 887
56. + T cells via a CD30-dependent mechanism. J Clin Invest 113 (2004) 310
57. + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol 174 (2005) 1783
58. Semiltova N., Shen X.D., Fishbein M.C., et al. Posttransplant administration of allochimeric major histocompatibility complex class-I-molecules induces true transplantation tolerance. Transplantation 75 (2003) 550
59. Sato Y., Ichida T., Watanabe H., et al. Repeating intraportal donor-specific transfusion may induce tolerance following adult living-related donor liver transplantation. Hepato Gastroenterol 50 (2003) 601
60. Bielekova B., Goodwin B., Richert N., et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis. Results of a phase II clinical trial with an altered peptide ligand. Nat Med 6 (2000) 1167
61. + T cell help. J Exp Med 186 (1997) 65
62. Marth T., Strober W., and Kelsall B.L. High dose oral tolerance in ovalbumin TCR- transgenic mice. Systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis. J Immunol 157 (1996) 2348