Genetic variation in the hepatic lipase gene and the risk of coronary heart disease among US diabetic men: Potential interaction with obesity

Diabetologia

Volumn 49, Issue 7, 2006, Pages 1552-1559

  Zhang, C ^a   Lopez Ridaura, R ^a,b   Rimm, E B ^a,b   Li, T ^a   Hunter, D J ^a,b   Hu, F B ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Coronary heart disease; Diabetes; Gene; Hepatic lipase; Interaction; Obesity

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER TRIACYLGLYCEROL LIPASE;

ADULT; AGED; ANALYTIC METHOD; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE DURATION; FOLLOW UP; GENE; GENE INTERACTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEPATIC LIPASE GENE; HUMAN; ISCHEMIC HEART DISEASE; LEAN BODY WEIGHT; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RISK; UNITED STATES; WAIST CIRCUMFERENCE;

ADULT; AGED; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIFE STYLE; LIPASE; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; UNITED STATES;

EID: 33744928073     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0235-2     Document Type: Article

References (47)

1. Garg A, Grundy SM (1990) Management of dyslipidemia in NIDDM. Diabetes Care 13:153-169
2. Cohen JC, Wang Z, Grundy SM, Stoesz MR, Guerra R (1994) Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels. J Clin Invest 94:2377-2384
3. Deeb SS, Zambon A, Carr MC, Ayyobi AF, Brunzell JD (2003) Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet. J Lipid Res 44:1279-1286
4. Jansen H, Verhoeven AJ, Sijbrands EJ (2002) Hepatic lipase: a pro- or anti-atherogenic protein? J Lipid Res 43:1352-1362
5. Applebaum-Bowden D (1995) Lipases and lecithin: cholesterol acyltransferase in the control of lipoprotein metabolism. Curr Opin Lipidol 6:130-135
6. Thuren T (2000) Hepatic lipase and HDL metabolism. Curr Opin Lipidol 11:277-283
7. Cooper AD (1997) Hepatic uptake of chylomicron remnants. J Lipid Res 38:2173-2192
8. Tan CE, Foster L, Caslake MJ et al (1995) Relations between plasma lipids and postheparin plasma lipases and VLDL and LDL subfraction patterns in normolipemic men and women. Arterioscler Thromb Vasc Biol 15:1839-1848
9. Carr MC, Hokanson JE, Zambon A et al (2001) The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity. J Clin Endocrinol Metab 86:2831-2837
10. Nie L, Wang J, Clark LT et al (1998) Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence ostheparin plasma hepatic lipase activity. J Lipid Res 39:1127-1130
11. Dreon DM, Fernstrom HA, Campos H, Blanche P, Williams PT, Krauss RM (1998) Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men. Am J Clin Nutr 67:828-836
12. Campos H, Dreon DM, Krauss RM (1995) Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low density lipoprotein subclasses. J Lipid Res 36:462-472
13. Taskinen MR, Valimaki M, Nikkila EA, Kuusi T, Ylikahri R (1985) Sequence of alcohol-induced initial changes in plasma lipoproteins (VLDL and HDL) and lipolytic enzymes in humans. Metabolism 34:112-119
14. Valimaki M, Kahri J, Laitinen K et al (1993) High density lipoprotein subfractions, apolipoprotein A-I containing lipoproteins, lipoprotein (a), and cholesterol ester transfer protein activity in alcoholic women before and after ethanol withdrawal. Eur J Clin Invest 23:406-417
15. Giada F, Baldo-Enzi G, Baiocchi MR et al (1991) Specialized physical training programs: effects on serum lipoprotein cholesterol, apoproteins A-I and B and lipolytic enzyme activities. J Sports Med Phys Fitness 31:196-203
16. Mendoza SG, Carrasco H, Zerpa A et al (1991) Effect of physical training on lipids, lipoproteins, apolipoproteins, lipases, and endogenous sex hormones in men with premature myocardial infarction. Metabolism 40:368-377
17. Teran-Garcia M, Santoro N, Rankinen T et al (2005) HERITAGE Family Study. Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study. Diabetes 54:2251-2255
18. Cohen JC, Vega GL, Grundy SM (1999) Hepatic lipase: new insights from genetic and metabolic studies. Curr Opin Lipidol 10:259-267
19. Guerra R, Wang J, Grundy SM, Cohen JC (1997) A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proc Natl Acad Sci USA 94:4532-4537
20. Tahvanainen E, Syvanne M, Frick MH et al (1998) Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene. The LOCAT Study Investigators. J Clin Invest 101:956-960
21. Deeb SS, Peng R (2000) The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity. J Lipid Res 41:155-158
22. Botma GJ, Verhoeven AJ, Jansen H (2001) Hepatic lipase promoter activity is reduced by the C-480T and G-216A substitutions present in the common LIPC gene variant, and is increased by upstream stimulatory factor. Atherosclerosis 154:625-632
23. De Oliveira e Silva ER, Kong M, Han Z et al (1999) Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females. J Lipid Res 40:1211-1221
24. Jansen H, Verhoeven AJ, Weeks L et al (1997) Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients. Arterioscler Thromb Vasc Biol 17:2837-2842
25. Zambon A, Deeb SS, Hokanson JE, Brown BG, Brunzell JD (1998) Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol. Arterioscler Thromb Vasc Biol 18:1723-1729
26. Hokanson JE, Cheng S, Snell-Bergeon JK et al (2002) A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetes. Diabetes 51:1208-1213
27. Dugi KA, Brandauer K, Schmidt N et al (2001) Low hepatic lipase activity is a novel risk factor for coronary artery disease. Circulation 104:3057-3062
28. Fan Y, Laaksonen R, Janatuinen T et al (2001) Hepatic lipase gene variation is related to coronary reactivity in healthy young men. Eur J Clin Invest 31:574-580
29. Andersen RV, Wittrup HH, Tybjaerg-Hansen A, Steffensen R, Schnohr P, Nordestgaard BG (2003) Hepatic lipase mutations, elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study. J Am Coll Cardiol 41:1972-1982
30. Hokanson JE, Kamboh MI, Scarboro S, Eckel RH, Hamman RF (2003) Effects of the hepatic lipase gene and physical activity on coronary heart disease risk. Am J Epidemiol 158:836-843
31. Ji J, Herbison CE, Mamotte CD, Burke V, Taylor RR, van Bockxmeer FM (2002) Hepatic lipase gene -514 C/T polymorphism and premature coronary heart disease. J Cardiovasc Risk 9:105-113
32. Whiting BM, Anderson JL, Muhlestein JB et al (2005) Intermountain Heart Collaborative Study Group. Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease. Am Heart J 150:243-250
33. Burdon KP, Langefeld CD, Beck SR et al (2005) Association of genes of lipid metabolism with measures of subclinical cardiovascular disease in the Diabetes Heart Study. J Med Genet 42:720-724
34. Fan YM, Salonen JT, Koivu TA et al (2004) Hepatic lipase C-480T polymorphism modifies the effect of HDL cholesterol on the risk of acute myocardial infarction in men: a prospective population based study. J Med Genet 41:e28
35. Zhang C, Lopez-Ridaura R, Rimm EB, Rifai N, Hunter DJ, Hu FB (2005) Interactions between the -514 C-T polymorphism of the hepatic lipase gene and lifestyle factors in relation to high density-lipoprotein concentrations among US diabetic men. Am J Clin Nutr 81:1429-1435
36. National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057
37. Expert Committee on the diagnosis and classification of diabetes mellitus (1997) Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20:1183-1197
38. Hu FB, Leitzmann MF, Stampfer MJ, Colditz GA, Willett WC, Rimm EB (2001) Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med 161:1542-1548
39. Rose G, Blackburn H (1982) WHO Monograph Series: Cardiovascular Survey Methods. World Health Organization, Geneva
40. Rimm EB, Giovannucci EL, Willett WC et al (1991) Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 338:464-468
41. Stampfer MJ, Willett WC, Speizer FE et al (1984) Test of the National Death Index. Am J Epidemiol 119:837-839
42. Rimm EB, Stampfer MJ, Colditz GA, Chute CG, Litin LB, Willett WC (1990) Validity of self-reported waist and hip circumferences in men and women. Epidemiology 1:466-473
43. Schulze MB, Rimm EB, Li T, Rifai N, Stampfer MJ, Hu FB (2004) C-reactive protein and incident cardiovascular events among men with diabetes. Diabetes Care 27:889-894
44. WHO Expert Committee (1995) Physical status: the use and interpretation of anthropometry. WHO Technical Report Series no. 854. World Health Organization, Geneva
45. Carr MC, Hokanson JE, Deeb SS, Purnell JQ, Mitchell ES, Brunzell JD (1999) A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women. Arterioscler Thromb Vasc Biol 19:2701-2707
46. St-Pierre J, Miller-Felix I, Paradis ME et al (2003) Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men. Mol Genet Metab 78:31-36
47. Ordovas JM, Corella D, Demissie S et al (2002) Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study. Circulation 106:2315-2321