Methodological approaches to exploring epileptic disorders in the human brain in vitro

Journal of Neuroscience Methods

Volumn 155, Issue 1, 2006, Pages 1-19

  Köhling, Rüdiger ^a   Avoli, Massimo ^b,c  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b MCGILL UNIVERSITY   (Canada)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Epilepsy; Human tissue; Neocortex

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOPYRIDINE; ANTICONVULSIVE AGENT; BICUCULLINE; CALCIUM ION; CARBAMAZEPINE; MAGNESIUM ION; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

BRAIN SLICE; CELL MEMBRANE; DEPOLARIZATION; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; EPILEPSY; EPILEPTIC DISCHARGE; HUMAN; HYPERPOLARIZATION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; METHODOLOGY; NERVE CELL PLASTICITY; NEUROPHYSIOLOGY; NONHUMAN; OOCYTE; OPTICS; PATHOLOGY; PRIORITY JOURNAL; REVIEW; STIMULUS RESPONSE; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION;

BIOPSY; BRAIN; DISSECTION; ELECTROPHYSIOLOGY; EPILEPSY; HUMANS; NEUROCHEMISTRY; NEURONS; NEUROPHARMACOLOGY; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES;

EID: 33744924848     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2006.04.009     Document Type: Review

References (148)

1. Andrew R.D., Adams J.R., and Polischuk T.M. Imaging NMDA- and kainate-induced intrinsic optical signals from the hippocampal slice. J Neurophysiol 76 (1996) 2707-2717
2. Aronica E., Gorter J.A., Ramkema M., Redeker S., Ozbas-Gerceker F., van Vliet E.A., et al. Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy. Epilepsia 45 (2004) 441-451
3. Avoli M. Inhibitory potentials in neurons of the deep layers of the in vitro neocortical slice. Brain Res. 370 April (1) (1986) 165-170
4. 0 in the human epileptogenic neocortex maintained in vitro. Brain Res 417 (1987) 199-203
5. Avoli M., and Olivier A. Electrophysiological properties and synaptic responses in the deep layers of the human epileptogenic neocortex maintained in vitro. J Neurophysiol 61 (1989) 589-606
6. Avoli M., Drapeau C., Louvel J., Pumain R., Olivier A., and Villemure J.G. Epileptiform activity induced by low extracellular magnesium in the human cortex maintained in vitro. Ann Neurol 30 (1991) 589-596
7. Avoli M., Mattia D., Siniscalchi A., Perreault P., and Tomaiuolo F. Pharmacology and electrophysiology of a synchronous GABA-mediated potential in the human neocortex. Neuroscience 62 (1994) 655-666
8. Avoli M., Hwa G.G.C., Mattia D., Olivier A., and Villemure J.G. Microphysiology of human neocortex in vitro. In: Guerrini R., et al. (Ed). Dysplasias of cerebral cortex and epilepsy (1995), Lippincott-Raven Publishers, Philadelphia 35-42
9. A-mediated inhibition and in vitro epileptogenesis in the human neocortex. J Neurophysiol 73 (1995) 468-484
10. Avoli M., Barbarosie M., Lücke A., Nagao T., Lopantsev V., and Köhling R. Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro. J Neurosci 16 (1996) 3912-3924
11. Avoli M., Louvel J., Kurcewicz I., Pumain R., and Barbarosie M. Extracellular free potassium and calcium during synchronous activity induced by 4-aminopyridine in the juvenile rat hippocampus. J Physiol (Lond) 493 (1996) 707-717
12. Avoli M., Bernasconi A., Mattia D., Olivier A., and Hwa G.G.C. Epileptiform discharges in the human dysplastic neocortex: in vitro physiology and pharmacology. Ann Neurol 46 (1999) 816-826
13. Barbarosie M., Louvel J., D'Antuono M., Kurcewicz I., and Avoli M. Masking synchronous GABA-mediated potentials controls limbic seizures. Epilepsia 43 (2002) 1469-1479
14. Beck H., Blumcke I., Kral T., Clusmann H., Schramm J., Wiestler O.D., et al. Properties of a delayed rectifier potassium current in dentate granule cells isolated from the hippocampus of patients with chronic temporal lobe epilepsy. Epilepsia 37 (1996) 892-901
15. 2+ currents in acutely isolated human hippocampal granule cells. J Neurophysiol 77 (1997) 1526-1537
16. Beck H., Clusmann H., Kral T., Schramm J., Heinemann U., and Elger C.E. Potassium currents in acutely isolated human hippocampal dentate granule cells. J Physiol 498 (1997) 73-85
17. 2+ currents in epilepsy. Epilepsy Res 32 (1998) 321-332
18. Beck H., Goussakov I.V., Lie A., Helmstaedter C., and Elger C.E. Synaptic plasticity in the human dentate gyrus. J Neurosci 20 (2000) 7080-7086
19. Becker A.J., Urbach H., Scheffler B., Baden T., Normann S., Lahl R., et al. Focal cortical dysplasia of Taylor's balloon cell type: mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis. Ann Neurol 52 (2002) 29-37
20. Becker A.J., Chen J., Zien A., Sochivko D., Normann S., Schramm J., et al. Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy. Eur J Neurosci 18 (2003) 2792-2802
21. Bordey A., and Sontheimer H. Properties of human glial cells associated with epileptic seizure foci. Epilepsy Res 32 (1998) 286-303
22. Buckle P.J., and Haas H.L. Enhancement of synaptic transmission by 4-aminopyridine in hippocampal slices of the rat. J Physiol 326 (1982) 109-122
23. Cepeda C., Andre V.M., Vinters H.V., Levine M.S., and Mathern G.W. Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia?. Epilepsia 46 Suppl. 5 (2005) 82-88
24. Cohen I., Navarro V., Clemenceau S., Baulac M., and Miles R. On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 298 (2002) 1418-1421
25. Colder B.W., Frysinger R.C., Wilson C.L., Harper R.M., and Engel Jr. J. Decreased neuronal burst discharge near site of seizure onset in epileptic human temporal lobes. Epilepsia 37 (1996) 113-121
26. Cummins T.R., Xia Y., and Haddad G.G. Functional properties of rat and human neocortical voltage-sensitive sodium currents. J Neurophysiol 71 (1994) 1052-1064
27. A receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex. Brain 127 (2004) 1626-1640
28. Dietrich D., Clusmann H., Kral T., Steinhauser C., Blumcke I., Heinemann U., et al. Two electrophysiologically distinct types of granule cells in epileptic human hippocampus. Neuroscience 90 (1999) 1197-1206
29. Dietrich D., Kral T., Clusmann H., Friedl M., and Schramm J. Reduced function of L-AP4-sensitive metabotropic glutamate receptors in human epileptic sclerotic hippocampus. Eur J Neurosci 11 (1999) 1109-1113
30. Dietrich D., Kral T., Clusmann H., Friedl M., and Schramm J. Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus. Neuropharmacology 42 (2002) 297-305
31. Dingledine R. Hippocampus: Synaptic pharmacology. In: Dingledine R. (Ed). Brain Slices (1984), Plenum Press, New York
32. Draguhn A., Traub R.D., Schmitz D., and Jefferys J.G. Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro. Nature 394 (1998) 189-192
33. 2+ currents in pancreatic islet B cells. FEBS Lett 251 (1989) 167-172
34. 2+ epileptiform activity in human temporal slices. Exp Brain Res 107 (1995) 321-325
35. Foehring R.C., Lorenzon N.M., Herron P., and Wilson C.J. Correlation of physiologically and morphologically identified neuronal types in the human association cortex in vitro. J Neurophysiol 66 (1991) 1825-1837
36. Foehring R.C., and Waters R.S. Contributions of low-threshold calcium current and anomalous rectifier (Ih) to slow depolarizations underlying burst firing in human neocortical neurons in vitro. Neurosci Lett 124 (1991) 17-21
37. Franck J.E., Pokorny J., Kunkel D.D., and Schwartzkroin P.A. Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus. Epilepsia 36 (1995) 543-558
38. Gabriel S., Njunting M., Pomper J.K., Merschhemke M., Sanabria E.R., Eilers A., et al. Stimulus and potassium-induced epileptiform activity in the human dentate gyrus from patients with and without hippocampal sclerosis. J Neurosci 24 (2004) 10416-10430
39. Gibbs III J.W., Zhang Y.F., Kao C.Q., Holloway K.L., Oh K.S., and Coulter D.A. Characterization of GABAA receptor function in human temporal cortical neurons. J Neurophysiol 75 (1996) 1458-1471
40. Gloor P. The temporal lobe and limbic system (1997), Oxford University Press, Oxford
41. Gorji A., Scheller D., Straub H., Tegtmeier F., Kohling R., Hohling J.M., et al. Spreading depression in human neocortical slices. Brain Res 906 (2001) 74-83
42. Gorji A., and Speckmann E.J. Spreading depression enhances the spontaneous epileptiform activity in human neocortical tissues. Eur J Neurosci 19 (2004) 3371-3374
43. Greatbatch W., Piersma B., Shannon F.D., and Calhoon Jr. S.W. Polarization phenomena relating to physiological electrodes. Ann N Y Acad Sci 167 (1969) 722-744
44. Gutnick M.J., Connors B.W., and Prince D.A. Mechanisms of neocortical epileptogenesis in vitro. J Neurophysiol 48 (1982) 1321-1335
45. Haglund M.M., and Hochman D.W. Optical imaging of epileptiform activity in human neocortex. Epilepsia 45 Suppl. 4 (2004) 43-47
46. Haglund M.M., Ojemann G.A., and Hochman D.W. Optical imaging of epileptiform and functional activity in human cerebral cortex. Nature 358 (1992) 668-671
47. Halliwell J.V. M-current in human neocortical neurones. Neurosci Lett 67 (1986) 1-6
48. Heinemann U., Lux H.D., and Gutnick M.J. Extracellular free calcium and potassium during paroxsmal activity in the cerebral cortex of the cat. Exp Brain Res 27 (1977) 237-243
49. Heinemann U., Dreier J., Leschinger A., Stabel J., Draguhn A., and Zhang C. Effects of anticonvulsant drugs on hippocampal neurons. Hippocampus 4 (1994) 291-296
50. Hermann A., and Gorman A.L. Effects of 4-aminopyridine on potassium currents in a molluscan neuron. J Gen Physiol 78 (1981) 63-86
51. Hinterkeuser S., Schröder W., Hager G., Seifert G., Blumcke I., Elger C.E., et al. Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances. Eur J Neurosci 12 (2000) 2087-2096
52. Holthoff K., and Witte O.W. Intrinsic optical signals in rat neocortical slices measured with near-infrared dark-field microscopy reveal changes in extracellular space. J Neurosci 16 (1996) 2740-2749
53. Hwa G.G., and Avoli M. Cesium potentiates epileptiform activities induced by bicuculline methiodide in rat neocortex maintained in vitro. Epilepsia 32 (1991) 747-754
54. Hwa G.G., and Avoli M. The involvement of excitatory amino acids in neocortical epileptogenesis: NMDA and non-NMDA receptors. Exp Brain Res 86 (1991) 248-256
55. Hwa G.G., Avoli M., Oliver A., and Villemure J.G. Bicuculline-induced epileptogenesis in the human neocortex maintained in vitro. Exp Brain Res 83 (1991) 329-339
56. Isokawa M., Avanzini G., Finch D.M., Babb T.L., and Levesque M.F. Physiologic properties of human dentate granule cells in slices prepared from epileptic patients. Epilepsy Res 9 (1991) 242-250
57. Isokawa M., and Levesque M.F. Increased NMDA responses and dendritic degeneration in human epileptic hippocampal neurons in slices. Neurosci Lett 132 (1991) 212-216
58. Isokawa M., Levesque M., Fried I., and Engel Jr. J. Glutamate currents in morphologically identified human dentate granule cells in temporal lobe epilepsy. J Neurophysiol 77 (1997) 3355-3369
59. Jensen M.S., and Yaari Y. The relationship between interictal and ictal paroxysms in an in vitro model of focal hippocampal epilepsy. Ann Neurol 24 (1998) 591-598
60. Jones R.S., and Lambert J.D. Synchronous discharges in the rat entorhinal cortex in vitro: site of initiation and the role of excitatory amino acid receptors. Neuroscience 34 (1990) 657-670
61. Kano T., Inaba Y., and Avoli M. Periodic oscillatory activity in parahippocampal slices maintained in vitro. Neuroscience 130 (2005) 1041-1053
62. Kerfoot C., Vinters H.V., and Mathern G.W. Cerebral cortical dysplasia: giant neurons show potential for increased excitation and axonal plasticity. Dev Neurosci 21 (1999) 260-270
63. 0 in human epileptic non-sclerotic and sclerotic hippocampal area CA1. Eur J Neurosci 12 (2000) 2039-2048
64. Koch U.R., Musshoff U., Pannek H.W., Ebner A., Wolf P., Speckmann E.J., et al. Intrinsic excitability, synaptic potentials, and short-term plasticity in human epileptic neocortex. J Neurosci Res 80 (2005) 715-726
65. Köhling R., Lücke A., Straub H., and Speckmann E.J. A portable chamber for long-distance transport of surviving human brain slice preparations. J Neurosci Methods 67 (1996) 233-236
66. Köhling R., Schmidinger A., Hulsmann S., Vanhatalo S., Lucke A., Straub H., et al. Anoxic terminal negative DC-shift in human neocortical slices in vitro. Brain Res 741 (1996) 174-179
67. Köhling R., Lücke A., Straub H., Speckmann E.J., Tuxhorn I., Wolf P., et al. Spontaneous sharp waves in human neocortical slices excised from epileptic patients. Brain 121 (1998) 1073-1087
68. Köhling R., Que M., Zilles K., and Speckmann E.J. Current-source density profiles associated with sharp waves in human epileptic neocortical tissue. Neuroscience 94 (1999) 1039-1050
69. Köhling R., Straub H., and Speckmann E.J. Differential involvement of L-type calcium channels in epileptogenesis of rat hippocampal slices during ontogenesis. Neurobiol Dis 7 (2000) 471-482
70. Köhling R., Höhling J.M., Straub H., Kuhlmann D., Kuhnt U., Tuxhorn I., et al. Optical monitoring of neuronal activity during spontaneous sharp waves in chronically epileptic human neocortical tissue. J Neurophysiol 84 (2000) 2161-2165
71. Köhling R., Reinel J., Vahrenhold J., Hinrichs K., and Speckmann E.J. Spatio-temporal patterns of neuronal activity: analysis of optical imaging data using geometric shape matching. J Neurosci Methods 114 (2002) 17-23
72. Kostopoulos G., Drapeau C., Avoli M., Olivier A., and Villemeure J.G. Endogenous adenosine can reduce epileptiform activity in the human epileptogenic cortex maintained in vitro. Neurosci Lett 106 (1989) 119-124
73. Kuras A., and Gutmaniene N. Preparation of carbon-fibre microelectrode for extracellular recording of synaptic potentials. J Neurosci Methods 62 (1995) 207-212
74. Lamsa K., and Kaila K. Ionic mechanisms of spontaneous GABAergic events in rat hippocampal slices exposed to 4-aminopyridine. J Neurophysiol 78 (1997) 2582-2591
75. Lazarowski A., Sevlever G., Taratuto A., Massaro M., and Rabinowicz A. Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy. Pediatr Neurol 21 (1999) 731-734
76. Lazarowski A., Lubieniecki F., Camarero S., Pomata H., Bartuluchi M., Sevlever G., et al. Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy. Pediatr Neurol 30 (2004) 102-106
77. Lie A.A., Becker A., Behle K., Beck H., Malitschek B., Conn P.J., et al. Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann Neurol 47 (2000) 26-35
78. Lie A.A., Blümcke I., Volsen S.G., Wiestler O.D., Elger C.E., and Beck H. Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy. Neuroscience 93 2 (1999) 449-456
79. Lieberman D.N., and Mody I. Properties of single NMDA receptor channels in human dentate gyrus granule cells. J Physiol 518 (1999) 55-70
80. Lorenzon N.M., and Foehring R.C. Relationship between repetitive firing and afterhyperpolarizations in human neocortical neurons. J Neurophysiol 67 (1992) 350-363
81. Loup F., Wieser H.G., Yonekawa Y., Aguzzi A., and Fritschy J.M. Selective alterations in GABAA receptor subtypes in human temporal lobe epilepsy. J Neurosci 20 (2000) 5401-5419
82. Louvel J., Pumain R., Avoli M., Kurcewicz I., Devaux B., and Chodkiewicz J.P. GABAA inhibition controls the calcium flows during NMDA-dependent epileptiform activity in human epileptogenic neocortex. Epilepsy Res Suppl 12 (1996) 293-300
83. Louvel J., Papatheodoropoulos C., Siniscalchi A., Kurciewicz I., Pumain R., Devaux B., et al. GABA-Mediated synchronization in the human cortex: elevations in extracellular potassium and presynaptic mechanisms. Neuroscience 105 (2001) 803-813
84. Lücke A., Kohling R., Straub H., Moskopp D., Wassmann H., and Speckmann E.J. Changes of extracellular calcium concentration induced by application of excitatory amino acids in the human neocortex in vitro. Brain Res 671 (1995) 222-226
85. MacVicar B.A., and Hochman D. Imaging of synaptically evoked intrinsic optical signals in hippocampal slices. J Neurosci 11 (1991) 1458-1469
86. Mangan P.S., and Kapur J. Factors underlying bursting behavior in a network of cultured hippocampal neurons exposed to zero magnesium. J Neurophysiol 91 (2004) 946-957
87. Masukawa L.M., Higashima M., Kim J.H., and Spencer D.D. Epileptiform discharges evoked in hippocampal brain slices from epileptic patients. Brain Res 493 (1989) 168-174
88. Masukawa L.M., Wang H., O'Connor M.J., and Uruno K. Prolonged field potentials evoked by 1 Hz stimulation in the dentate gyrus of temporal lobe epileptic human brain slices. Brain Res 721 (1996) 132-139
89. Mathern G.W., Pretorius J.K., Kornblum H.I., Mendoza D., Lozada A., Leite J.P., et al. Human hippocampal AMPA and NMDA mRNA levels in temporal lobe epilepsy patients. Brain 120 (1997) 1937-1959
90. 2+ of NMDA responses in spinal cord neurones. Nature 309 (1984) 261-263
91. McCormick D.A. GABA as an inhibitory neurotransmitter in human cerebral cortex. J Neurophysiol 62 (1989) 1018-1027
92. McCormick D.A., and Williamson A. Convergence and divergence of neurotransmitter action in human cerebral cortex. Proc Natl Acad Sci USA 86 (1989) 8098-8102
93. Meldrum B.S., and Chapman A.G. Excitatory amino acid receptors and antiepileptic drug development. Adv Neurol 79 (1999) 965-978
94. Mody I., Lambert J.D., and Heinemann U. Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J Neurophysiol 57 (1987) 869-888
95. + accumulations and synchronous GABA-mediated potentials evoked by 4-aminopyridine in the adult rat hippocampus. Exp Brain Res 109 (1996) 71-82
96. Moshe S.L. Mechanisms of action of anticonvulsant agents. Neurology 55 (2000) S32-S40
97. Mußhoff U., Kohling R., Lucke A., Speckmann E., Tuxhorn I., Wolf P., et al. Vigabatrin reduces epileptiform activity in brain slices from pharmacoresistant epilepsy patients. Eur J Pharmacol 401 (2000) 167-172
98. Palma E., Esposito V., Mileo A.M., Di Gennaro G., Quarato P., Giangaspero F., et al. Expression of human epileptic temporal lobe neurotransmitter receptors in Xenopus oocytes: an innovative approach to study epilepsy. Proc Natl Acad Sci USA 99 (2002) 15078-15083
99. Palma E., Ragozzino D.A., Di Angelantonio S., Spinelli G., Trettel F., Martinez-Torres A., et al. Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain. Proc Natl Acad Sci USA 101 (2004) 10183-10188
100. Papatheodoropoulos C., and Kostopoulos G. Spontaneous, low frequency (approximately 2-3 Hz) field activity generated in rat ventral hippocampal slices perfused with normal medium. Brain Res Bull 57 (2002) 187-193
101. Patt S., Labrakakis C., Bernstein M., Weydt P., Cervos-Navarro J., Nisch G., et al. Neuron-like physiological properties of cells from human oligodendroglial tumors. Neuroscience 71 (1996) 601-611
102. Patt S., Steenbeck J., Hochstetter A., Kraft R., Huonker R., Haueisen J., et al. Source localization and possible causes of interictal epileptic activity in tumor-associated epilepsy. Neurobiol Dis 7 (2000) 260-269
103. Perreault P., and Avoli M. Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slices. J Neurophysiol 65 (1991) 771-785
104. Prince D.A. Neurophysiology of epilepsy. Annu Rev Neurosci 1 (1978) 395-415
105. Psarropoulou C., and Avoli M. CPP, an NMA-receptor antagonist, blocks 4-aminopyridine-induced spreading depression episodes but not epileptiform activity in immature rat hippocampal slices. Neurosci Lett 135 (1992) 139-143
106. Psarropoulou C., and Avoli M. 4-Aminopyridine-induced spreading depression episodes in immature hippocampus: developmental and pharmacological characteristics. Neuroscience 55 (1993) 57-68
107. Remy S., Gabriel S., Urban B.W., Dietrich D., Lehmann T.N., Elger C.E., et al. A novel mechanism underlying drug resistance in chronic epilepsy. Ann Neurol 53 (2003) 469-479
108. - co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397 (1999) 251-255
109. Rivera C., Voipio J., Thomas-Crusells J., Li H., Emri Z., Sipila S., et al. Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci 24 (2004) 4683-4691
110. Rogawski M.A. The NMDA receptor, NMDA antagonists and epilepsy therapy: a status report. Drugs 44 (1992) 279-292
111. Rüschenschmidt C., Köhling R., Schwarz M., Straub H., Gorji A., Siep E., Ebner A., Pannek H.W., Tuxhorn I., Wolf P., and Speckmann E.J. Characterization of a fast transient outward current in neocortical neurons from epilepsy patients. J Neurosci Res. 75 March (6) (2004) 807-816
112. Rutecki P.A., Grossman R.G., Armstrong D., and Irish-Loewen S.J. Electrophysiological connections between the hippocampus and entorhinal cortex in patients with complex partial seizures. J Neurosurg 70 (1989) 667-675
113. Sanchez-Vives M.V., and McCormick D.A. Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nat Neurosci 3 (2000) 1027-1034
114. Sayer R.J., Brown A.M., Schwindt P.C., and Crill W.E. Calcium currents in acutely isolated human neocortical neurons. J Neurophysiol 69 (1993) 1596-1606
115. Schröder W., Hinterkeuser S., Seifert G., Schramm J., Jabs R., Wilkin G.P., et al. Functional and molecular properties of human astrocytes in acute hippocampal slices obtained from patients with temporal lobe epilepsy. Epilepsia 41 Suppl. 6 (2000) S181-S184
116. Schwartzkroin P.A., and Prince D.A. Microphysiology of human cerebral cortex studied in vitro. Brain Res 115 (1976) 497-500
117. Schwartzkroin P.A., and Prince D.A. Changes in excitatory and inhibitory synaptic potentials leading to epileptogenic activity. Brain Res 183 (1980) 61-76
118. Schwartzkroin P.A. In vivo and in vitro microphysiology of focal epilepsy. Electroencephalogr Clin Neurophysiol Suppl. 39 (1987) 177-183
119. Schwartzkroin P.A., Turner D.A., Knowles W.D., and Wyler A.R. Studies of human and monkey "epileptic" neocortex in the in vitro slice preparation. Ann Neurol 13 (1983) 249-257
120. Schwartzkroin P.A., and Knowles W.D. Intracellular study of human epileptic cortex: in vitro maintenance of epileptiform activity?. Science 223 (1984) 709-712
121. Shumate M.D., Lin D.D., Gibbs III J.W., Holloway K.L., and Coulter D.A. GABA(A) receptor function in epileptic human dentate granule cells: comparison to epileptic and control rat. Epilepsy Res 32 (1998) 114-128
122. Seifert G., Hüttmann K., Schramm J., and Steinhäuser C. Enhanced relative expression of glutamate receptor 1 flip AMPA receptor subunits in hippocampal astrocytes of epilepsy patients with Ammon's horn sclerosis. J Neurosci 24 (2004) 1996-2003
123. Siddiqui A., Kerb R., Weale M.E., Brinkmann U., Smith A., Goldstein D.B., et al. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 348 (2003) 1442-1448
124. Spreafico R., Battaglia G., Arcelli P., Andermann F., Dubeau F., Palmini A., et al. Cortical dysplasia: an immunocytochemical study of three patients. Neurology 50 (1998) 27-36
125. 2+] in combined hippocampal-entorhinal cortex slices: modulation by receptors for norepinephrine and N-methyl-d-aspartate. Epilepsy Res 1 (1987) 53-62
126. Straub H., Köhling R., Höhling J., Rundfeldt C., Tuxhorn I., Ebner A., et al. Effects of retigabine on rhythmic synchronous activity of human neocortical slices. Epilepsy Res 44 (2001) 155-165
127. Straub H., Kuhnt U., Hohling J.M., Kohling R., Gorji A., Kuhlmann D., et al. Stimulus-induced patterns of bioelectric activity in human neocortical tissue recorded by a voltage sensitive dye. Neuroscience 121 (2003) 587-604
128. Strowbridge B.W., Masukawa L.M., Spencer D.D., and Shepherd G.M. Hyperexcitability associated with localizable lesions in epileptic patients. Brain Res. 587 March (1) (1992) 158-163
129. Swanson T.H., Sperling M.R., and O'Connor M.J. Strong paired pulse depression of dentate granule cells in slices from patients with temporal lobe epilepsy. J Neural Transm 105 (1998) 613-625
130. Tancredi V., Hwa G.G.C., Zona C., Brancati A., and Avoli M. Low magnesium epileptogenesis in the rat hippocampal slice: electrophysiological and pharmacological features. Brain Res 511 (1990) 280-290
131. Tasker J.G., Peacock W.J., and Dudek F.E. Local synaptic circuits and epileptiform activity in slices of neocortex from children with intractable epilepsy. J Neurophysiol 67 (1992) 496-507
132. Tasker J.G., Hoffman N.W., Kim Y.I., Fisher R.S., Peacock W.J., and Dudek F.E. Electrical properties of neocortical neurons in slices from children with intractable epilepsy. Neurophysiology 75 (1996) 931-939
133. Taylor D.C., Falconer M.A., Bruton C.J., and Corsellis J.A.N. Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34 (1971) 369-387
134. Traub R.D., and Dingledine R. Model of synchronized epileptiform bursts induced by high potassium in CA3 region of rat hippocampal slice. Role of spontaneous EPSPs in initiation. J Neurophysiol 64 (1990) 1009-1018
135. Traynelis S.F., and Dingledine R. Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice. J Neurophysiol 59 (1998) 259-276
136. Uruno K., O'Connor M.J., and Masukawa L.M. Effects of bicuculline and baclofen on paired-pulse depression in the dentate gyrus of epileptic patients. Brain Res 695 (1995) 163-172
137. Vale C., and Sanes D.H. Afferent regulation of inhibitory synaptic transmission in the developing auditory midbrain. J Neurosci 20 (2000) 1912-1921
138. Vollmar W., Gloger J., Berger E., Kortenbruck G., Köhling R., Speckmann E.J., et al. RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients. Neurobiol Dis 15 (2004) 371-379
139. Vreugdenhil M., van Veelen C.W., van Rijen P.C., Lopes da Silva F.H., and Wadman W.J. Effect of valproic acid on sodium currents in cortical neurons from patients with pharmaco-resistant temporal lobe epilepsy. Epilepsy Res 32 (1998) 309-320
140. Vreugdenhil M., Hoogland G., van Veelen C.W., and Wadman W.J. Persistent sodium current in subicular neurons isolated from patients with temporal lobe epilepsy. Eur J Neurosci 19 (2004) 2769-2778
141. Weissinger F., Buchheim K., Siegmund H., Heinemann U., and Meierkord H. Optical imaging reveals characteristic seizure onsets, spread patterns, and propagation velocities in hippocampal-entorhinal cortex slices of juvenile rats. Neurobiol Dis 7 (2000) 286-298
142. Whittington M.A., Traub R.D., and Jefferys J.G. Erosion of inhibition contributes to the progression of low magnesium bursts in rat hippocampal slices. J Physiol 486 (1995) 723-734
143. Williamson A., Spencer S.S., and Spencer D.D. Depth electrode studies and intracellular dentate granule cell recordings in temporal lobe epilepsy. Ann Neurol 38 (1995) 778-787
144. Williamson A., Patrylo P.R., Lee S., and Spencer D.D. Physiology of human cortical neurons adjacent to cavernous malformations and tumors. Epilepsia 44 (2003) 1413-1419
145. Wuarin J.P., Peacock W.J., and Dudek F.E. Single-electrode voltage-clamp analysis of the N-methyl-d-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy. J Neurophysiol 67 (1992) 84-93
146. Zhang C.L., Dreier J.P., and Heinemann U. Paroxysmal epileptiform discharges in temporal lobe slices after prolonged exposure to low magnesium are resistant to clinically used anticonvulsants. Epilepsy Res 20 (1995) 05-11
147. Zilles K., Qu M.S., Köhling R., and Speckmann E.J. Ionotropic glutamate and GABA receptors in human epileptic neocortical tissue: quantitative in vitro receptor autoradiography. Neuroscience 94 (1999) 1051-1061
148. Zuckermann E.C., and Glaser G.H. Hippocampal epileptic activity induced by localized ventricular perfusion with high-potassium cerebrospinal fluid. Exp Neurol 20 (1968) 87-110