Enhanced Relative Expression of Glutamate Receptor 1 Flip AMPA Receptor Subunits in Hippocampal Astrocytes of Epilepsy Patients with Ammon's Horn Sclerosis

Journal of Neuroscience

Volumn 24, Issue 8, 2004, Pages 1996-2003

  Seifert, Gerald ^a   Hüttmann, Kerstin ^a   Schramm, Johannes ^a   Steinhäuser, Christian ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

AMPA receptor; Astrocyte; Epilepsy; Hippocampus; Human; Patch clamp; RT PCR; Splicing

Indexed keywords

4 [2 (PHENYLSULFONYLAMINO)ETHYLTHIO] 2,6 DIFLUOROPHENOXYACETAMIDE; ACETAMIDE DERIVATIVE; AMPA RECEPTOR; CYCLOTHIAZIDE; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; IONOTROPIC RECEPTOR; MESSENGER RNA; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; CONTROLLED STUDY; DEPOLARIZATION; DRUG RECEPTOR BINDING; DRUG RESISTANCE; EPILEPSY; GENE EXPRESSION; GLIA CELL; HIPPOCAMPAL SCLEROSIS; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; NERVE CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN VARIANT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RESTRICTION MAPPING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA CONFORMATION; RNA SPLICING; SCLEROSIS; SIGNAL TRANSDUCTION; SPLICE VARIANT; TEMPORAL LOBE EPILEPSY;

ALTERNATIVE SPLICING; ASTROCYTES; BENZOTHIADIAZINES; CELL SEPARATION; EPILEPSY; HIPPOCAMPUS; HUMANS; PATCH-CLAMP TECHNIQUES; PHENOXYACETATES; PROTEIN SUBUNITS; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCLEROSIS;

EID: 1442300141     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3904-03.2004     Document Type: Article

References (42)

1. Bergles DE, Roberts JD, Somogyi P, Jahr CE (2000) Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 405:187-191.
2. Bordey A, Sontheimer H (1998) Properties of human glial cells associated with epileptic seizure foci. Epilepsy Res 32:286-303.
3. Chew LJ, Fleck MW, Wright P, Scherer SE, Mayer ML, Gallo V (1997) Growth factor-induced transcription of GluR1 increases functional AMPA receptor density in glial progenitor cells. J Neurosci 17:227-240.
4. De Lanerolle NC, Eid T, Von Campe G, Kovacs I, Spencer DD, Brines M (1998) Glutamate receptor subunits GluR1 and GluR2/3 distribution shows reorganization in the human epileptogenic hippocampus. Eur J Neurosci 10:1687-1703.
5. Eid T, Kovacs I, Spencer DD, De Lanerolle NC (2002) Novel expression of AMPA-receptor subunit GluR1 on mossy cells and CA3 pyramidal neurons in the human epileptogenic hippocampus. Eur J Neurosci 15:517-527.
6. Engel Jr J (1993) Update on surgical treatment of the epilepsies. Neurology 43:1612-1617.
7. Fleck MW, Bähring R, Patneau DK, Mayer ML (1996) AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide. J Neurophysiol 75:2322-2333.
8. A receptor gene expression in adult rat hippocampus: an in situ hybridization study. J Neurosci 14:2697-2707.
9. Gall CM (1993) Seizure-induced changes in neurotrophin expression: implications for epilepsy. Exp Neurol 124:150-166.
10. Gall CM, Berschauer R, Isackson PJ (1994) Seizures increase basic fibroblast growth factor mRNA in adult rat forebrain neurons and glia. Mol Brain Res 21:190-205.
11. Glass M, Dragunow M (1995) Neurochemical and morphological changes associated with human epilepsy. Brain Res Rev 21:29-41.
12. Grooms SY, Opitz T, Bennett MVL, Zukin RS (2000) Status epilepticus decreases glutamate receptor 2 mRNA and protein expression in hippocampal pyramidal cells before neuronal death. Proc Natl Acad Sci USA 97:3631-3636.
13. Grosskreutz J, Zoerner A, Schlesinger F, Krampfl K, Dengler R, Bufler J (2003) Kinetic properties of human AMPA-type glutamate receptors expressed in HEK293 cells. Eur J Neurosci 17:1173-1178.
14. Hinterkeuser S, Schröder W, Hager G, Seifert G, Blümcke I, Elger CE, Schramm J, Steinhäuser C (2000) Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances. Eur J Neurosci 12:2087-2096.
15. Holland PM, Abramson RD, Watson R, Gelfand DH (1991) Detection of specific polymerase chain reaction product by using the 5′-3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc Natl Acad Sci USA 88:7276-7280.
16. Hufnagel A, Zentner J, Fernandez G, Wolf HK, Schramm J, Elger CE (1997) Multiple subpial transection for control of epileptic seizures: effectiveness and safety. Epilepsia 38:678-688.
17. + currents in glial cells of mouse hippocampal slices. Pflügers Arch 426:310-319.
18. Kamphuis W, Monyer H, De Rijk TC, Lopes da Silva FH (1992) Hippocampal kindling increases the expression of glutamate receptor-A Flip and -B Flip mRNA in dentate granule cells. Neurosci Lett 148:51-54.
19. Kamphuis W, De Rijk TC, Talamini LM, Lopes da Silva FH (1994) Rat hippocampal kindling induces changes in the glutamate receptor mRNA expression patterns in dentate granule neurons. Eur J Neurosci 6:1119-1127.
20. Kral T, Clusmann H, Urbach J, Schramm J, Elger CE, Kurthen M, Grunwald T (2002) Preoperative evaluation for epilepsy surgery (Bonn Algorithm). Zentralbl Neurochir 63:106-110.
21. Lux H-D, Heinemann U, Dietzel I (1986) Ionic changes and alterations in the size of the extracellular space during epileptic activity. Adv Neurol 44:619-639.
22. Mathern GW, Babb TL, Micevych PE, Blanco CE, Pretorius JK (1997) Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus. Mol Chem Neuropathol 30:53-76.
23. Matthias K, Kirchhoff F, Seifert G, Hüttmann K, Matyash M, Kettenmann H, Steinhäuser C (2003) Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus. J Neurosci 23:1750-1758.
24. Medhurst AD, Harrison DC, Read SJ, Campbell CA, Robbins MJ, Pangalos MN (2000) The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models. J Neurosci Methods 98:9-20.
25. Mosbacher J, Schoepfer R, Monyer H, Burnashev N, Seeburg PH, Ruppersberg JP (1994) A molecular determinant for submillisecond desensitization in glutamate receptors. Science 266:1059-1062.
26. Partin KM, Patneau DK, Mayer ML (1994) Cyclothiazide differentially modulates desensitization of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants. Mol Pharmacol 46:129-136.
27. Pollard H, Héron A, Moreau J, Ben-Ari Y, Khrestchatisky M (1993) Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia. Neuroscience 57:545-554.
28. Porter JT, McCarthy KD (1996) Hippocampal astrocytes in situ respond to glutamate released from synaptic terminals. J Neurosci 16:5073-5081.
29. Rogawski MA, Donevan SD (1999) AMPA receptors in epilepsy and as targets for anti-epileptic drugs. Adv Neurol 79:947-963.
30. Rosa MLNM, Jefferys JGR, Sanders MW, Pearson RCA (1999) Expression of mRNAs encoding flip isoforms of GluR1 and GluR2 glutamate receptors is increased in rat hippocampus in epilepsy induced by tetanus toxin. Epilepsy Res 36:243-251.
31. Sanchez RM, Koh S, Rio C, Wang C, Lamperti ED, Sharma D, Corfas G, Jensen FE (2001) Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures. J Neurosci 21:8154-8163.
32. + channels in astrocytes of mouse hippocampus. Mol Cell Neurosci 19:447-458.
33. 2+ permeability. Eur J Neurosci 7:1872-1881.
34. Seifert G, Steinhäuser C (2001) Ionotropic glutamate receptors in astrocytes. Prog Brain Res 132:287-299.
35. Seifert G, Rehn L, Weber M, Steinhäuser C (1997a) AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampus. Mol Brain Res 47:286-294.
36. Seifert G, Zhou M, Steinhäuser C (1997b) Analysis of AMPA receptor properties during postnatal development of mouse hippocampal astrocytes. J Neurophysiol 78:2916-2923.
37. Seifert G, Schröder W, Hinterkeuser S, Schumacher T, Schramm J, Steinhäuser C (2002) Changes in flip/flop splicing of astroglial AMPA receptors in human temporal lobe epilepsy. Epilepsia 43:S162-S167.
38. Seifert G, Weber M, Schramm J, Steinhäuser C (2003) Changes in splice variant expression and subunit assembly of AMPA receptors during maturation of hippocampal astrocytes. Mol Cell Neurosci 22:248-258.
39. Sekiguchi M, Fleck MW, Mayer ML, Takeo J, Chiba Y, Yamashita S, Wada K (1997) A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide. J Neurosci 17:5760-5771.
40. Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K (1998) Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures. Br J Pharmacol 123:1294-1303.
41. Verkhratsky A, Steinhäuser C (2000) Ion channels in glial cells. Brain Res Rev 32:380-412.
42. Wilding TJ, Huettner JE (1995) Differential antagonism of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines. Mol Pharmacol 47:582-587.