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Volumn 1068, Issue 1, 2006, Pages 214-224

Role of connexin43 in osteoblast response to physical load

Author keywords

Bone formation; Connexin43; Gap junctions; Mechanical strain

Indexed keywords

CONNEXIN 43; PROSTAGLANDIN E2;

EID: 33744765514     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1346.023     Document Type: Conference Paper
Times cited : (37)

References (30)
  • 1
    • 0029932193 scopus 로고    scopus 로고
    • Structure of gap junction intercellular channels
    • Yeager, M. & B.J. Nicholson. 1996. Structure of gap junction intercellular channels. Curr. Opin. Struct. Biol. 6: 183 192.
    • (1996) Curr. Opin. Struct. Biol. , vol.6 , pp. 183-192
    • Yeager, M.1    Nicholson, B.J.2
  • 2
    • 0030013202 scopus 로고    scopus 로고
    • Connexins, connexons, and intercellular communication
    • Goodenough, D.A., J.A. Goliger & D.L. Paul. 1996. Connexins, connexons, and intercellular communication. Annu. Rev. Biochem. 65: 475 502.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 475-502
    • Goodenough, D.A.1    Goliger, J.A.2    Paul, D.L.3
  • 3
    • 0024364960 scopus 로고
    • Voltage-activated and stretch activated Ba2+-conducting channels in an osteoblast-like cell line (UMR 106-01)
    • Duncan, R.L. & S. Misler. 1989. Voltage-activated and stretch activated Ba2+-conducting channels in an osteoblast-like cell line (UMR 106-01). FEBS Lett. 251: 17 21.
    • (1989) FEBS Lett. , vol.251 , pp. 17-21
    • Duncan, R.L.1    Misler, S.2
  • 4
    • 0029880371 scopus 로고    scopus 로고
    • Distinct responses of different populations of bone cells to mechanical stress
    • Mikuni-Takagaki, Y., Y. Suzuki, T. Kawase & S. Saito. 1996. Distinct responses of different populations of bone cells to mechanical stress. Endocrinology 137: 2028 2035.
    • (1996) Endocrinology , vol.137 , pp. 2028-2035
    • Mikuni-Takagaki, Y.1    Suzuki, Y.2    Kawase, T.3    Saito, S.4
  • 5
    • 0031792839 scopus 로고    scopus 로고
    • Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: Modulation by cation channel blockades
    • Sakai, K., M. Mohtai & Y. Iwamoto. 1998. Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: modulation by cation channel blockades. Calcif. Tissue Int. 63: 515 520.
    • (1998) Calcif. Tissue Int. , vol.63 , pp. 515-520
    • Sakai, K.1    Mohtai, M.2    Iwamoto, Y.3
  • 6
    • 0031917705 scopus 로고    scopus 로고
    • Cyclic stretch enhances gap junctional communication between osteoblastic cells
    • Ziambaras, K., F. Lecanda, T.H. Steinberg & R. Civitelli. 1998. Cyclic stretch enhances gap junctional communication between osteoblastic cells. J. Bone Miner. Res. 13: 218 228.
    • (1998) J. Bone Miner. Res. , vol.13 , pp. 218-228
    • Ziambaras, K.1    Lecanda, F.2    Steinberg, T.H.3    Civitelli, R.4
  • 7
    • 0035141749 scopus 로고    scopus 로고
    • Expression of functional gap junctions and regulation by fluid flow in osteocyte-like MLO-Y4 cells
    • Cheng, B., S. Zhao, J. Luo, et al. 2001. Expression of functional gap junctions and regulation by fluid flow in osteocyte-like MLO-Y4 cells. J. Bone Miner. Res. 16: 249 259.
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 249-259
    • Cheng, B.1    Zhao, S.2    Luo., J.3
  • 8
    • 0035918140 scopus 로고    scopus 로고
    • Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts
    • You, J., G.C. Reilly, X. Zhen, et al. 2001. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J. Biol. Chem. 276: 13365 13371.
    • (2001) J. Biol. Chem. , vol.276 , pp. 13365-13371
    • You, J.1    Reilly, G.C.2    Zhen., X.3
  • 9
    • 0042206541 scopus 로고    scopus 로고
    • Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism
    • Alford, A.I., C.R. Jacobs & H.J. Donahue. 2003. Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism. Bone 33: 64 70.
    • (2003) Bone , vol.33 , pp. 64-70
    • Alford, A.I.1    Jacobs, C.R.2    Donahue, H.J.3
  • 10
    • 21844442343 scopus 로고    scopus 로고
    • Mechanical strain opens connexin 43 hemichannels in osteocytes: A novel mechanism for the release of prostaglandin
    • Cherian, P.P., A.J. Siller-Jackson, S. Gu, et al. 2005. Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol. Biol. Cell 16: 3100 3106.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 3100-3106
    • Cherian, P.P.1    Siller-Jackson, A.J.2    Gu., S.3
  • 11
    • 0028926506 scopus 로고
    • Morphologic stages in lamellar bone formation stimulated by a potent mechanical stimulus
    • Rubin, C.T., T.S. Gross, K.J. McLeod & S.D. Bain. 1995. Morphologic stages in lamellar bone formation stimulated by a potent mechanical stimulus. J. Bone Miner. Res. 10: 488 495.
    • (1995) J. Bone Miner. Res. , vol.10 , pp. 488-495
    • Rubin, C.T.1    Gross, T.S.2    McLeod, K.J.3    Bain, S.D.4
  • 12
    • 0036179760 scopus 로고    scopus 로고
    • Noninvasive loading of the murine tibia: An in vivo model for the study of mechanotransduction
    • Gross, T.S., S. Srinivasan, C.C. Liu, et al. 2002. Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction. J. Bone Miner. Res. 17: 493 501.
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 493-501
    • Gross, T.S.1    Srinivasan, S.2    Liu., C.C.3
  • 13
    • 0842330737 scopus 로고    scopus 로고
    • Mechanotransduction in the cortical bone is most efficient at loading frequencies of 5-10 Hz
    • Warden, S.J. & C.H. Turner. 2004. Mechanotransduction in the cortical bone is most efficient at loading frequencies of 5-10 Hz. Bone 34: 261 270.
    • (2004) Bone , vol.34 , pp. 261-270
    • Warden, S.J.1    Turner, C.H.2
  • 14
    • 0031035011 scopus 로고    scopus 로고
    • Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells
    • Klein-Nulend, J., E.H. Burger, C.M. Semeins, et al. 1997. Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells. J. Bone Miner. Res. 12: 45 51.
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 45-51
    • Klein-Nulend, J.1    Burger, E.H.2    Semeins., C.M.3
  • 15
    • 0026048690 scopus 로고
    • Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts
    • Reich, K.M. & J.A. Frangos. 1991. Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts. Am. J. Physiol. 261: C428 C432.
    • (1991) Am. J. Physiol. , vol.261
    • Reich, K.M.1    Frangos, J.A.2
  • 16
    • 21644466461 scopus 로고    scopus 로고
    • Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts
    • Genetos, D.C., D.J. Geist, D. Liu, et al. 2005. Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J. Bone Miner. Res. 20: 41 49.
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 41-49
    • Genetos, D.C.1    Geist, D.J.2    Liu., D.3
  • 17
    • 0030696015 scopus 로고    scopus 로고
    • The in vivo anabolic actions of prostaglandins in bone
    • Jee, W.S. & Y.F. Ma. 1997. The in vivo anabolic actions of prostaglandins in bone. Bone 21: 297 304.
    • (1997) Bone , vol.21 , pp. 297-304
    • Jee, W.S.1    Ma, Y.F.2
  • 18
    • 0029998565 scopus 로고    scopus 로고
    • Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo
    • Forwood, M.R. 1996. Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo. J. Bone Miner. Res. 11: 1688 1693.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 1688-1693
    • Forwood, M.R.1
  • 19
    • 0242290338 scopus 로고    scopus 로고
    • Effects of mechanical strain on the function of gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor
    • Cherian, P.P., B. Cheng, S. Gu, et al. 2003. Effects of mechanical strain on the function of gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor. J. Biol. Chem. 278: 43146 43156.
    • (2003) J. Biol. Chem. , vol.278 , pp. 43146-43156
    • Cherian, P.P.1    Cheng, B.2    Gu., S.3
  • 20
    • 0034037735 scopus 로고    scopus 로고
    • Gap junctions and biophysical regulation of bone cell differentiation
    • Donahue, H.J. 2000. Gap junctions and biophysical regulation of bone cell differentiation. Bone 26: 417 422.
    • (2000) Bone , vol.26 , pp. 417-422
    • Donahue, H.J.1
  • 21
    • 0347126458 scopus 로고    scopus 로고
    • Development of mice with osteoblast-specific connexin43 gene deletion
    • Castro, C.H., J.P. Stains, S. Sheikh, et al. 2003. Development of mice with osteoblast-specific connexin43 gene deletion. Cell Commun. Adhes. 10: 445 450.
    • (2003) Cell Commun. Adhes. , vol.10 , pp. 445-450
    • Castro, C.H.1    Stains, J.P.2    Sheikh., S.3
  • 22
    • 0034645070 scopus 로고    scopus 로고
    • Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction
    • Lecanda, F., P.M. Warlow, S. Sheikh, et al. 2000. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J. Cell Biol. 151: 931 944.
    • (2000) J. Cell Biol. , vol.151 , pp. 931-944
    • Lecanda, F.1    Warlow, P.M.2    Sheikh., S.3
  • 23
    • 0028118677 scopus 로고
    • Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells
    • Steinberg, T.H., R. Civitelli, S.T. Geist, et al. 1994. Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells. EMBO J. 13: 744 750.
    • (1994) EMBO J. , vol.13 , pp. 744-750
    • Steinberg, T.H.1    Civitelli, R.2    Geist., S.T.3
  • 24
    • 0031688655 scopus 로고    scopus 로고
    • Bone response to in vivo mechanical loading in two breeds of mice
    • Akhter, M.P., D.M. Cullen, E.A. Pedersen, et al. 1998. Bone response to in vivo mechanical loading in two breeds of mice. Calcif. Tissue Int. 63: 442 449.
    • (1998) Calcif. Tissue Int. , vol.63 , pp. 442-449
    • Akhter, M.P.1    Cullen, D.M.2    Pedersen., E.A.3
  • 25
    • 0035192335 scopus 로고    scopus 로고
    • Mechanical loading of diaphyseal bone in vivo: The strain threshold for an osteogenic response varies with location
    • Hsieh, Y.F., A.G. Robling, W.T. Ambrosius, et al. 2001. Mechanical loading of diaphyseal bone in vivo: the strain threshold for an osteogenic response varies with location. J. Bone Miner. Res. 16: 2291 2297.
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 2291-2297
    • Hsieh, Y.F.1    Robling, A.G.2    Ambrosius., W.T.3
  • 26
    • 0347627147 scopus 로고    scopus 로고
    • Enabling bone formation in the aged skeleton via rest-inserted mechanical loading
    • Srinivasan, S., S.C. Agans, K.A. King, et al. 2003. Enabling bone formation in the aged skeleton via rest-inserted mechanical loading. Bone 33: 946 955.
    • (2003) Bone , vol.33 , pp. 946-955
    • Srinivasan, S.1    Agans, S.C.2    King., K.A.3
  • 27
    • 3242883440 scopus 로고    scopus 로고
    • Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis
    • Castro, C.H., C.S. Shin, J.P. Stains, et al. 2004. Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis. J. Cell Sci. 117: 2853 2864.
    • (2004) J. Cell Sci. , vol.117 , pp. 2853-2864
    • Castro, C.H.1    Shin, C.S.2    Stains., J.P.3
  • 28
    • 14344253211 scopus 로고    scopus 로고
    • Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene
    • Alam, I., S.J. Warden, A.G. Robling & C.H. Turner. 2005. Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene. J. Bone Miner. Res. 20: 438 446.
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 438-446
    • Alam, I.1    Warden, S.J.2    Robling, A.G.3    Turner, C.H.4
  • 29
    • 33744759069 scopus 로고
    • Parathyroid hormone (PTH) exhibits dual actions on the stretch-activated cation channel (SA-cat) of the osteoblast
    • Duncan, R.L. & K.A. Hruska. 1992. Parathyroid hormone (PTH) exhibits dual actions on the stretch-activated cation channel (SA-cat) of the osteoblast. J. Bone Miner. Res. 7: S242.
    • (1992) J. Bone Miner. Res. , vol.7
    • Duncan, R.L.1    Hruska, K.A.2
  • 30
    • 0029111672 scopus 로고
    • Mechanotransduction in bone: Role of strain rate
    • Turner, C.H., I. Owan & Y. Takano. 1995. Mechanotransduction in bone: role of strain rate. Am. J. Physiol. 269: E438 E442.
    • (1995) Am. J. Physiol. , vol.269
    • Turner, C.H.1    Owan, I.2    Takano, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.